Development and characterization of a self-double-emulsifying drug delivery system containing both epigallocatechin-3-gallate and α-lipoic acid

Hu, Caibiao; Zhao, Guodong; Xia, Qiang; Sun, Rui

doi:10.1007/s10853-015-9194-7

Cited by 18 publications

(13 citation statements)

References 49 publications

(50 reference statements)

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“…Industrially, it is used limited due to its instability. But Hu et al [98] had developed a novel SDEDDS preparation by formulating hydrophillic surfactants with w/o emulsion. They had concluded that SDEDDS of a peptidomimetic drug can be delivered.…”

Section: Se Suppository Formulations (Non-oral)mentioning

confidence: 99%

Self Emulsifying Drug Delivery System: A Recent Approach

Bindhani

Mohapatra

Kar³

2019

Asian J. Chem.

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In recent years, nearly 40 % newer drugs compounds are hydrophobic in nature, which is a major challenge now-a-days for oral drug delivering due to low aqueous solubility. Lipid based drug delivery system is one of the favourable approach for poorly soluble compounds which can improve the drug absorption and oral bioavailability. Due to ion-pairing with appropriate surfactant and co-surfactant the macromolecular drug molecular oil droplet being found in the gut flow oral absorption which sufficiently stable towards lipase. Due to the formation of emulsified drug in micron level, it can efficiently endow the oral bioavailability. Several comprehensive papers have been published in the literature illustration diverse type of lipid based formulation with recent advancements. This article is based on an exhaustive and updated review on newer technology which out line an explicit discussion on its formulations and industrial scale up.

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Section: Se Suppository Formulations (Non-oral)mentioning

confidence: 99%

Self Emulsifying Drug Delivery System: A Recent Approach

Bindhani

Mohapatra

Kar³

2019

Asian J. Chem.

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“…The drug release from QT‐SDEDDS was investigated using the dialysis bag method . About 2 mL of QT‐SDEDDS suspension or 2 mL of quercetin solution (1.0 mg/mL in 1,2‐propylene glycol) were put into dialysis bags (MWCS 12 000 Da, Biosharp, USA), respectively.…”

Section: Methodsmentioning

confidence: 99%

“…The non‐aqueous QT‐SDEDDS formulations were prepared using a modified two‐step method . Firstly, primary O/O emulsions were prepared as follows: PGPR and cetostearyl alcohol were dissolved in the outer oil phase.…”

Section: Methodsmentioning

confidence: 99%

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Enhanced oral bioavailability of quercetin by a new non‐aqueous self‐double‐emulsifying drug delivery system

Wang

Qian

et al. 2016

Euro J Lipid Sci & Tech

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The present study investigated a new non‐aqueous self‐double‐emulsifying drug delivery system (SDEDDS) to enhance oral bioavailability of quercetin (QT), a drug with poor water solubility. The new formulation was prepared using a modified two‐step method and evaluated in vitro and in vivo. The optimized formulation consisted of oil‐in‐oil emulsions and hydrophilic surfactant that could spontaneously emulsify to oil‐in‐oil‐in‐water (O/O/W) double emulsions in the mixed aqueous gastrointestinal environment, with drugs mainly encapsulated in the inner oil phase of the double emulsions. Furthermore, the non‐aqueous QT‐SDEDDS exhibited sustained release of quercetin under conditions mimicking gastrointestinal tract, and gave significantly higher AUC and Cmax than did quercetin control suspension (p < 0.05). In particular, the AUC of the non‐aqueous QT‐SEDDS was about 5.22‐fold higher than that of drug control suspension, with an absolute bioavailability of 26.67%. The obtained results demonstrated that SDEDDS was successfully developed and could be a promising technique for improving the oral bioavailability of quercetin with low solubility. Practical applications: Conventional SDEDDS is mainly designed to encapsulate, protect, and release hydrophilic bioactive components. Hence, the new non‐aqueous SDEDDS could as a drug delivery system to encapsulate hydrophobic drug with low oral bioavailability. Pharmacokinetic studies have displayed increased relative bioavailability (more than fivefold) of QT‐SDEDDS compared to quercetin suspension in rats after oral administration, with an absolute bioavailability of 26.67%. The new formulation was prepared using a modified two‐step method, which is widespread and easy to handle. Furthermore, the used excipients are considered generally recognized as safe (GRAS) for addition to food and/or drug products. Regard to industrial production aspects, the non‐aqueous SDEDDS have the chance to be exploited as drug delivery system in commercial products. Hence, the non‐aqueous SDEDDS could be applicable delivery system for hydrophobic compounds with low oral bioavailability. (i) The new non‐aqueous QT‐SDEDDS could spontaneously emulsify to oil‐in‐oil‐in‐water (O/O/W) double emulsions upon mild agitation by dilution in aqueous media; and (ii) after oral administration in rats, the non‐aqueous SDEDDS displayed an absolute bioavailability of 26.67%, which was 5.22 times higher than that of quercetin control suspension.

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“…A multiple emulsion with an internal phase (NaOH; MgSO 4 ), organic phase (Parleam 4; Abil EM90), and external phase (Lutrol F127) has been reported as a relatively efficient and safe treatment in vitro for paraquat poisoning . In fact, in view of the large specific surface areas and high selectivity, the technique of emulsion with organic surfactants has been investigated in many fields such as (i) the removal of metal ions and recovery of organics in waste, (ii) the controlled release of drugs, and (iii) the removal of toxins from organisms . Nevertheless, because of the poor thermodynamic stability, probable toxicity, and low biocompatibility, such emulsions containing organic surfactants have limited applications, especially in pharmacy and food industries.…”

Section: Introductionmentioning

confidence: 99%

Preparation and in vitro evaluation of hydrophobic‐modified montmorillonite stabilized pickering emulsion for overdose acetaminophen removal

Zhang

Fan

et al. 2017

Can J Chem Eng

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Pickering emulsion stabilized with hydrophobic‐modified montmorillonite (HMMT) was proposed for treating acute overdose acetaminophen intoxication, with a rapid removal rate, better stability, and good biocompatibility. The tiny HMMT was able to adsorb at the oil‐water interface of the Pickering emulsion to reduce the interfacial energy along with the formation of solid particle layer, in order to enhance the stability of the emulsion and improve the removal performance. With a fast removal rate, the detoxifying Pickering emulsion removed 0.5 g/L acetaminophen in the simulated gastric fluid to 0.13 g/L in 6 min, which is less than the intoxication content of 0.15 g/L, with a leakage ratio of lower than 4 % in simulated intestinal fluid over 4 h. Such a detoxifying emulsion was prepared at 55 °C with 2 % organoclay (HMMT) as the emulsifier, 6 % tributyl phosphate (TBP) as the extractant, and 0.1 mol/L NaOH as the inner phase in the volume ratio of 5:7. All the results denoted that the Pickering emulsion could be a promising candidate for the acute oral intoxication treatment.

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Development and characterization of a self-double-emulsifying drug delivery system containing both epigallocatechin-3-gallate and α-lipoic acid

Cited by 18 publications

References 49 publications

Self Emulsifying Drug Delivery System: A Recent Approach

Self Emulsifying Drug Delivery System: A Recent Approach

Enhanced oral bioavailability of quercetin by a new non‐aqueous self‐double‐emulsifying drug delivery system

Preparation and in vitro evaluation of hydrophobic‐modified montmorillonite stabilized pickering emulsion for overdose acetaminophen removal

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