Developing electrodes chemically modified with cucurbit[6]uril to detect 3,4-methylenedioxymethamphetamine (MDMA) by voltammetry

Dynamic supramolecular polymers built from cucurbit[n]urils and viologens

“…CB[ n ]s are also not toxic, cheap and resistant to microorganisms, which makes them excellent candidates to replace cyclodextrins for most applications. Our own contribution to this field includes the stabilization of reactive species and drug carriers, and the use of CB[ n ] as structural elements in hybrid composites, as templates for nanoparticle synthesis, or to develop special catalysts and coatings, sensors and specialty polymers . Their ability to host a wide range of substrates is mainly due to the hydrophobicity of the inner cavity lacking hydrogen bond donor/acceptor moieties.…”

Calixarenes containing modified meso bridges

“…they form inclusion complexes useful in various fields, 1 form calixarene capsules, 2 are promising as chiral NMR solvating agents, 3 form gold 4 and silver 5 nanoparticles, are useful as catalysts 6 and as liquid crystals, 7 serve for design of sensors [8][9][10] and are promising as therapeutic agents. 11,12 Calixarenes belong to the family of cage macrocycles, including besides them cyclodextrins, [13][14][15] cucurbiturils 16,17 and pillararenes. 18 All macrocycles of this family are useful in the field of supramolecular chemistry for formation of inclusion complexes 1,[19][20][21] and rotaxanes in which they serve as rings.…”

Desenvolvimento de sensores eletroquímicos para a detecção voltamétrica de MDMA em amostras de interesse forense

“…Basicamente, a imobilização dessas moléculas ocorre por adsorção na superfície eletródica, via matrizes poliméricas, como o uso de PVC e Nafion ou através de misturas em eletrodos de trabalho de pastas de carbono [64,86,[91][92]]. …”

“…Além disso, conforme cálculos computacionais semi-empíricos, sabe-se que a CB [6] pode incluir parte da molécula de MDMA na sua cavidade interna, onde esta interação é maior a partir do anel heterocíclico contendo o grupo metilenodioxi ligado às posições 3 e 4 do anel aromático. E, para possibilitar a entrada do anel aromático na sua cavidade, deve ocorrer uma deformação do opérculo [64].…”