Developing a novel magnesium glycerophosphate/silicate-based organic-inorganic composite cement for bone repair

Ding, Zhengwen; Li, Hong; Wei, Jie; Li, Ruijiang; Yan, Yonggang

doi:10.1016/j.msec.2018.03.001

Cited by 25 publications

(14 citation statements)

References 41 publications

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“…The final setting time was obtained when the copper ring no longer left a visible print on the surface of the pastes. 11 Each sample was tested at least three times, and the average value was calculated.…”

Section: Setting Time Injectability and Mechanical Propertiesmentioning

confidence: 99%

Vitamin D3-loaded calcium citrate/calcium sulfate composite cement with enhanced physicochemical properties, drug release, and cytocompatibility

Chen

Ding

et al. 2020

J Biomater Appl

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Vitamin D3 (VD3), an important regulator of calcium and phosphate ion concentrations in blood serum, participates in bone formation by promoting calcium and citrate deposition at defect sites while further stimulating bone calcification and osteoblast function. In this study, VD3-loaded calcium sulfate (VD3/CS) and calcium citrate/calcium sulfate (VD3/ CC/CS) cements were successfully fabricated for the first time. The incorporation of VD3 into the cements did not alter their structures or physicochemical properties. Additionally, compared with the VD3/CS cement, the VD3/CC/CS composite cement showed higher mechanical strength (28.87 MPa), better injectability (94.48%), and more appropriate setting time (23.7 min). Depending on the method by which the loaded VD3 was adsorbed, both VD3/CS and VD3/CC/ CS cements could achieve sustained drug release. However, due to their different compositions, VD3/CS cement samples, owing to the dissolution of their matrix, showed faster VD3 release rates, while VD3/CC/CS composite cement samples showed more controlled VD3 release rates, owing to the presence of a physical barrier created by calcium citrate. The VD3/CC/CS composite cement samples also demonstrated excellent bioactivity at cellular level, indicating that the VD3/CC/CS composite cement might be beneficial for the localised treatment of bone defects, especially osteoporotic bone.

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Section: Setting Time Injectability and Mechanical Propertiesmentioning

confidence: 99%

Vitamin D3-loaded calcium citrate/calcium sulfate composite cement with enhanced physicochemical properties, drug release, and cytocompatibility

Chen

Ding

et al. 2020

J Biomater Appl

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“…Murine bone mesenchymal stem cells (mMSCs) (ATCC; Chinese Academy of Sciences, Shanghai, China) were cultured in Dulbecco's modified Eagle's medium (DMEM, Corning cellgro@, USA) supplemented with fetal bovine serum (10% v/v) (FBS, Gibco, Thermo Fisher Scientific, Australia) and penicillin‐streptomycin solution (1% v/v) (Gibco, Life Technologies, USA) in a humidified atmosphere at 37 °C with 5% CO 2 . According to previous reports, the hydrogel extracts were prepared by adding 16 g SG hydrogel ( V r = 1/2) fragments to 40 mL DMEM culture medium and immersed at 37 °C for 24 h. Then, the mixture was centrifuged and the supernatant through 0.22 µm sterile filter was collected to obtain the SG hydrogel extracts at concentrations of 0.4 g mL −1 . The extracts at concentrations of 0.05–0.2 g mL −1 were obtained by diluting the 0.4 g mL −1 extract with DMEM culture medium.…”

Section: Methodsmentioning

confidence: 98%

A Spray‐Filming Self‐Healing Hydrogel Fabricated from Modified Sodium Alginate and Gelatin as a Bacterial Barrier

Peng

et al. 2019

Macromolecular Bioscience

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Self-healing hydrogels as wound dressings still face challenges in infection prevention, especially in the dressing of mass wounds, due to their inflexibility and the slow formation of the protective film on the wound. Therefore, designing a spray-filming (rapid-forming) hydrogel that can serve as a bacterial barrier is of particular significance in the development of wound dressings. Here, a self-healing hydrogel based on adipic acid dihydrazidemodified gelatin (Gel-ADH) and monoaldehyde-modified sodium alginate (SA-mCHO) is prepared. Using dynamic, Schiff base bonds, the hydrogels exhibit excellent self-healing properties. Moreover, the gelation time of SA-mCHO/Gel-ADH (SG) hydrogels is shortened to 2-21 s, resulting in rapid filming by spraying the two precursor solutions. In addition, the rapid sprayfilming ability might offer sufficient flexibility and rapidity for dealing with mass and irregular wounds. Notably, the bacterial barrier experiments show that the SG hydrogel films could form an effective barrier to Staphylococcus aureus and Candida albicans for 12 h. Therefore, SG hydrogels could be used in wound dressings and they show great promise in applications associated with mass and irregular traumas.

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“…The viscosity values of the UWC mixes with NS and MgO were assessed with a rheometer (Rheometer R/S Plus, Brookfield, WI, USA). To observe the setting time of the fresh UWC mixes, paste samples were obtained after mixing the UWC concrete, and the initial and final setting times were investigated using Vicat needles [ 39 , 40 ] according to ASTM C 191 [ 41 ].…”

Section: Methodsmentioning

confidence: 99%

Evaluation of the Hydration Characteristics and Anti-Washout Resistance of Non-Dispersible Underwater Concrete with Nano-SiO2 and MgO

et al. 2021

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In this paper, the effect of nano-SiO2 (NS) and MgO on the hydration characteristics and anti-washout resistance of non-dispersible underwater concrete (UWC) was evaluated. A slump flow test, a viscosity test, and setting time measurement were conducted to identify the impacts of NS and MgO on the rheological properties of UWC. The pH and turbidity were measured to investigate the anti-washout performance of UWC mixes. To analyze the hydration characteristics and mechanical properties, hydration heat analysis, a compressive strength test, and thermogravimetric analyses were conducted. The experimental results showed that the fine particles of NS and MgO reduced slump flow, increased viscosity, and enhanced the anti-washout resistance of UWC. In addition, both NS and MgO shortened the initial and final setting times, and the replacement of MgO specimens slightly prolonged the setting time. NS accelerated the peak time and increased the peak temperature, and MgO delayed the hydration process and reduced the temperature due to the formation of brucite. The compressive results showed that NS improved the compressive strength of the UWC, and MgO slightly decreased the strength. The addition of NS also resulted in the formation of extra C–S–H, and the replacement of MgO caused the generation of a hydrotalcite phase.

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Developing a novel magnesium glycerophosphate/silicate-based organic-inorganic composite cement for bone repair

Cited by 25 publications

References 41 publications

Vitamin D3-loaded calcium citrate/calcium sulfate composite cement with enhanced physicochemical properties, drug release, and cytocompatibility

Vitamin D3-loaded calcium citrate/calcium sulfate composite cement with enhanced physicochemical properties, drug release, and cytocompatibility

A Spray‐Filming Self‐Healing Hydrogel Fabricated from Modified Sodium Alginate and Gelatin as a Bacterial Barrier

Evaluation of the Hydration Characteristics and Anti-Washout Resistance of Non-Dispersible Underwater Concrete with Nano-SiO2 and MgO

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