A Spray‐Filming Self‐Healing Hydrogel Fabricated from Modified Sodium Alginate and Gelatin as a Bacterial Barrier

Abstract

Self-healing hydrogels as wound dressings still face challenges in infection prevention, especially in the dressing of mass wounds, due to their inflexibility and the slow formation of the protective film on the wound. Therefore, designing a spray-filming (rapid-forming) hydrogel that can serve as a bacterial barrier is of particular significance in the development of wound dressings. Here, a self-healing hydrogel based on adipic acid dihydrazidemodified gelatin (Gel-ADH) and monoaldehyde-modified sodium alginate (SA-mCHO) is prepared. Using dynamic, Schiff base bonds, the hydrogels exhibit excellent self-healing properties. Moreover, the gelation time of SA-mCHO/Gel-ADH (SG) hydrogels is shortened to 2-21 s, resulting in rapid filming by spraying the two precursor solutions. In addition, the rapid sprayfilming ability might offer sufficient flexibility and rapidity for dealing with mass and irregular wounds. Notably, the bacterial barrier experiments show that the SG hydrogel films could form an effective barrier to Staphylococcus aureus and Candida albicans for 12 h. Therefore, SG hydrogels could be used in wound dressings and they show great promise in applications associated with mass and irregular traumas.

Biomimetic Hydrogels to Promote Wound Healing

“…Recently, sprayable hydrogels are becoming more attractive for wound dressing because they demonstrate high mixing efficiency, controllable spray area, and sufficient contact with soft tissues. Usually, the sprayable hydrogels are formed in situ rapidly through physical crosslinking ( Kumar and Jaiswal, 2016 ), Schiff base bond formation ( Du et al, 2020 ), and crosslinking of phenol groups ( Sun et al, 2020 ). Functional hydrogel can be constructed through incorporating antimicrobial peptide ( Annabi et al, 2017 ) and cerium oxide nanoparticles ( Cheng et al, 2021 ) to improve antibacterial activities and ROS-scavenging abilities.…”

“…After injection, the prepolymer solution can spread over wound area and then form hydrogel in situ to cover it ( Zhao et al, 2017a ; Wang et al, 2019c ) or by controlling injection to fill irregular wounds ( Lokhande et al, 2018 ; Chen et al, 2019b ) with minimal invasion and pain. Sprayable hydrogel is an emerging approach for wound management to offer an in situ forming, tunable and shape adaptable coverage without fluting in wound area ( Kumar and Jaiswal, 2016 ; Yan et al, 2019 ; Du et al, 2020 ). It would be the most convenient approach with excellent patient compliance.…”

Fabrication of New Fe3O4/PVA/(C6H7O6Na)n Nanohybrid Ferrogels for Antibacterial Applications

“…Furthermore, stretching bands characteristic of PVA were detected at 857 cm −1 (CC stretching) 19 , 1047-1147 cm −1 (C-O) 20 , 1350 cm −1 (=C-O-C), and 2966 cm −1 (CH 2 asymmetric stretching) 21 . The stretching bands characteristic of (C 6 H 7 O 6 Na) n were detected in the range 1473-1560 cm −1 (COO symmetric and asymmetric) 22 and at 1708 cm −1 (C=O) 23 . Interestingly, the From the theoretical viewpoint, the presence of alginate reduces the stiffness of PVA-based system by virtue of its low elongation break 25 .…”

Current Review on Polymeric Hydrogel Based

“…Notably, experiments with bacterial barriers show that the SG hydrogel films could be an effective barrier for 12 h for Staphylococcus aureus and Candida albicans. SG hydrogels could therefore be used in wound dressings and they show great promise in mass-related applications and frequent traumas 6 . Reactive oxygen species (ROS) over expression leads to the pathogenesis of various diseases such as atherosclerosis, myocardial infarction, cancer, and chronic inflammation; The production of materials which can control local adverse effects resulting from excessive ROS generation is therefore of great importance.…”

“…Therefore, skin tissue engineering has enticed considerable heedfulness from researchers as an optimistic approach for repairing partial/ full thickness burn tissue. [5][6][7][8][9][10][11][12] Moreover in the current review, various hydrogels with optimum biocompatibility and biodegradability have been widely investigated for use in skin tissue engineering. However, the biomaterials meant for the formulating the hydrogels, Collagen, Gelatin, Silk fibroin, Alginate, and Chitosan were found to be promising for skin tissue engineering.…”