Determining the presence and origin of collagenase in human periapical lesions

Barkhordar, Rahmat A.

doi:10.1016/s0099-2399(87)80096-1

Journal of Endodontics

1987

DOI: 10.1016/s0099-2399(87)80096-1

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Determining the presence and origin of collagenase in human periapical lesions

Rahmat A. Barkhordar¹

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Cited by 4 publications

References 29 publications

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Bioactive Chitosan Nanoparticles and Photodynamic Therapy Inhibit Collagen Degradation In Vitro

Persadmehr

Torneck

Cvitkovitch

et al. 2014

Journal of Endodontics

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This study evaluated the ability of photodynamic therapy (PDT), chitosan nanoparticles (CSnp), or their combination, to inhibit bacterial collagenase-mediated degradation of collagen. Rat type 1 fibrillar collagen matrices were untreated or treated with 2.5% glutaraldehyde (GD), 2.5% GD followed by 1% CSnp, 1% CSnp, PDT, or 1% CSnp followed by PDT. Samples, except untreated controls, were exposed to Clostridium histolyticum collagenase. The soluble digestion products were assessed by hydroxyproline assay and the remaining adherent collagen was quantified by picrosirius red (PSR) staining. Collagen treated with CSnp, PDT, or a combination of CSnp and PDT, exhibited less degradation than controls. The abundance of post-treatment residual collagen correlated with the extent of degradation. Fourier transform infrared (FTIR) spectroscopy analysis showed that PDT treatment enhanced collagen cross-linking.Immunoblotting of sedimented CSnp indicated that CSnp and collagenase bound with low affinity. However, CSnp-bound collagenase showed a significant reduction in collagenolytic activity compared with controls.III

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Bioactive Chitosan Nanoparticles and Photodynamic Therapy Inhibit Collagen Degradation In Vitro

Persadmehr

Torneck

Cvitkovitch

et al. 2014

Journal of Endodontics

View full text Add to dashboard Cite

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Biochemical and histochemical analysis of the enzyme arylsulfatase in human lesions of endodontic origin

Aqrabawi¹,

Schilder²,

Toselli³

et al. 1993

Journal of Endodontics

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Effects of a combination of an antibacterial agent (ofloxacin) and a collagenase inhibitor (FN-439) on the healing of rat periapical lesions

Anan¹,

Matsumoto²,

Hamachi³

et al. 1996

Journal of Endodontics

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Determining the presence and origin of collagenase in human periapical lesions

Cited by 4 publications

References 29 publications

Bioactive Chitosan Nanoparticles and Photodynamic Therapy Inhibit Collagen Degradation In Vitro

Bioactive Chitosan Nanoparticles and Photodynamic Therapy Inhibit Collagen Degradation In Vitro

Biochemical and histochemical analysis of the enzyme arylsulfatase in human lesions of endodontic origin

Effects of a combination of an antibacterial agent (ofloxacin) and a collagenase inhibitor (FN-439) on the healing of rat periapical lesions

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