Determining picogram quantities of uranium in urine by isotope dilution inductively coupled plasma mass spectrometry. Comparison with α-spectrometry

Haldimann, Max; Baduraux, Michel; Eastgate, Alan; Froidevaux, Pascal; O’Donovan, Sinead M.; Gunten, Danielle Von; Zoller, Otmar

doi:10.1039/b107455e

Cited by 34 publications

(22 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Successful application of alphaspectrometry has been reported for the determination of uranium concentration and uranium isotopic ratios in soil samples (9) or human urine samples (10,11). However, this technique requires tedious sample treatment steps and several days of acquisition time per sample may be necessary (9).…”

Section: Introductionmentioning

confidence: 98%

Validated Measurements of the Uranium Isotopic Signature in Human Urine Samples Using Magnetic Sector-Field Inductively Coupled Plasma Mass Spectrometry

Trešl

Wannemacker

Quétel

et al. 2003

Environ. Sci. Technol.

View full text Add to dashboard Cite

Increased interest in measuring uranium isotope ratios in environmental samples (biological materials, soils, dust particles, water) has come from the necessity to assess the health impact of the use of depleted uranium (DU) based ammunitions during recent military conflicts (e.g., Gulf war, Kosovo) and from the need to identify nondeclared nuclear activities (nuclear safeguards). In this context, very important decisions can arise which have to be based on measurement data of nondisputable uncertainty. The present study describes the certification to 2.5% (k = 2) relative combined uncertainty of n(235U)/n(238U) at ultralow uranium levels (approximately 5-20 pg g(-1)) in human urine samples. After sample decomposition and matrix separation, the isotope ratios were measured by means of a single-detector magnetic sector-field inductively coupled plasma mass spectrometry instrument fitted with an ultrasonic nebulizer. Correction for mass discrimination effects was obtained by means of the certified isotopic reference material IRMM-184. The analytical procedure developed was validated in three complementary ways. First, all major sources of uncertainty were identified and propagated together following the ISO/GUM guidelines. Second, this quality was controlled with a matrix matching NUSIMEP-3 sample (approximately 0.06-0.7% difference from certified). Third, the instrumental part of the procedure was proven to be reproducible from the confirmation of the results obtained for three samples remeasured 7 months later (approximately 1.5% difference). The results obtained for 33 individuals indicated that none seemed to have been exposed to contamination by DU.

show abstract

Section: Introductionmentioning

confidence: 98%

Validated Measurements of the Uranium Isotopic Signature in Human Urine Samples Using Magnetic Sector-Field Inductively Coupled Plasma Mass Spectrometry

Trešl

Wannemacker

Quétel

et al. 2003

Environ. Sci. Technol.

View full text Add to dashboard Cite

show abstract

“…Thermal ionization mass spectrometry (TIMS) [16] also provides accurate and precise measurements, but is not practical for large number of patient screenings since extensive sample preparations are required [2,[16][17][18]. Alpha and gamma particle spectrometries have also been used [19][20][21][22] but require long counting times, removal of uranium from the matrix and display detection limits 2-3 orders of magnitude worse than ICP-MS.…”

Section: Introductionmentioning

confidence: 99%

Determination of 236U/238U and 235U/238U isotope ratios in human urine by inductively coupled plasma mass spectrometry

Gray¹,

Zhang²,

Xu³

et al. 2012

Microchemical Journal

View full text Add to dashboard Cite

“…Examples include hemoglobin-bound absorption of Fe and Zn from the diet [3], absorption and retention of Se from milk spiked with 74 Se-selenite and 76 Se-selenate in men and infants [4,5], the effects of Fe supplementation during pregnancy on Zn absorption [6], investigation of caseinophosphopeptides on Ca absorption from drinks labeled with 44 Ca-lactate [7], and estimation of fractional loss of Fe from the body in subjects intrinsically labeled with 58 Fe. This may be of specific importance in clinical research into metabolic and kinetic studies.…”

Section: Single Element Versus Multielementmentioning

confidence: 99%

“…Among these methods, ICP-MS has been the leading technique because of its features such as excellent detection limits, insignificant interference, limited sample preparation, great dynamic range, fast analysis, and relatively low cost [2,41]. Alpha or gamma spectrometry [42][43][44] was used, but the majority was mass spectrometry methods. Alpha or gamma spectrometry [42][43][44] was used, but the majority was mass spectrometry methods.…”

Section: Case Study No 5: Analysis Of U Isotope Ratios By Using Icp-mentioning

confidence: 99%

Metal Toxicology in Clinical, Forensic, and Chemical Pathology

Centeno¹,

Todorov

Voet

et al. 2012

Analytical Techniques for Clinical Chemistry

View full text Add to dashboard Cite

Determining picogram quantities of uranium in urine by isotope dilution inductively coupled plasma mass spectrometry. Comparison with α-spectrometry

Cited by 34 publications

References 22 publications

Validated Measurements of the Uranium Isotopic Signature in Human Urine Samples Using Magnetic Sector-Field Inductively Coupled Plasma Mass Spectrometry

Validated Measurements of the Uranium Isotopic Signature in Human Urine Samples Using Magnetic Sector-Field Inductively Coupled Plasma Mass Spectrometry

Determination of 236U/238U and 235U/238U isotope ratios in human urine by inductively coupled plasma mass spectrometry

Metal Toxicology in Clinical, Forensic, and Chemical Pathology

Contact Info

Product

Resources

About