Metal Toxicology in Clinical, Forensic, and Chemical Pathology

Centeno, José A.; Todorov, Todor I.; Voet, Gijsbert B. van der; Mullick, Florabel G.

doi:10.1002/9781118271858.ch6

Cited by 3 publications

(2 citation statements)

References 46 publications

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“…The assessment of the isotopic ratio may supply more information than the total metal contents. For instance, the ratio of 207 Pb to 208 Pb in bone samples may be useful for identifying the sources of lead exposure, whereas determining total Pb in bone samples characterizes body burden [166]. Findings from such speciation studies may support the implementation of public health prevention and control measures.…”

Section: Toxic Metals Causing a Zinc Deficiency-a Model For The Conve...mentioning

confidence: 99%

Metal Profiles in Autism Spectrum Disorders: A Crosstalk between Toxic and Essential Metals

Błażewicz

Grabrucker

2022

IJMS

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Since hundreds of years ago, metals have been recognized as impacting our body’s physiology. As a result, they have been studied as a potential cure for many ailments as well as a cause of acute or chronic poisoning. However, the link between aberrant metal levels and neuropsychiatric illnesses such as schizophrenia and neurodevelopmental disorders, such as autism spectrum disorders (ASDs), is a relatively new finding, despite some evident ASD-related consequences of shortage or excess of specific metals. In this review, we will summarize past and current results explaining the pathomechanisms of toxic metals at the cellular and molecular levels that are still not fully understood. While toxic metals may interfere with dozens of physiological processes concurrently, we will focus on ASD-relevant activity such as inflammation/immune activation, mitochondrial malfunction, increased oxidative stress, impairment of axonal myelination, and synapse formation and function. In particular, we will highlight the competition with essential metals that may explain why both the presence of certain toxic metals and the absence of certain essential metals have emerged as risk factors for ASD. Although often investigated separately, through the agonistic and antagonistic effects of metals, a common metal imbalance may result in relation to ASD.

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Section: Toxic Metals Causing a Zinc Deficiency-a Model For The Conve...mentioning

confidence: 99%

Metal Profiles in Autism Spectrum Disorders: A Crosstalk between Toxic and Essential Metals

Błażewicz

Grabrucker

2022

IJMS

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“…2 Therefore, the World Health Organization (WHO) recommends that Pb(II) level in drinking water be limited to 10 ppb. 3 So far, several conventional analytical methods, such as atomic absorption spectrometry (AAS), 4 inductively coupled plasma atomic emission spectrometry (ICP-AES), 5 inductively coupled plasma mass spectrometry (ICP-MS), 6 and anodic stripping voltammetry (ASV), 7 have been employed for measuring lead ion with detection limits typically lower than the critical concentration in drinking water. Nevertheless, fluorescent detection has become one of the most convenient and inexpensive methods for Pb 2+ analysis with high sensitivity and selectivity, 8 particularly in biological systems.…”

Section: ■ Introductionmentioning

confidence: 99%

Ratiometric Fluorescent Detection of Pb²⁺ by FRET-Based Phthalocyanine-Porphyrin Dyads

et al. 2017

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Sensitive and selective detection of Pb is a very worthwhile endeavor in terms of both human health and environmental protection, as the heavy metal is fairly ubiquitous and highly toxic. In this study, we designed phthalocyanine-porphyrin (Pc-Por) heterodyads, namely, HPc-α-ZnPor (1) and HPc-β-ZnPor (2), by connecting a zinc(II) porphyrin moiety to the nonperipheral (α) or peripheral (β) position of a metal-free phthalocyanine moiety. Upon excitation at the porphyrin Soret region (420 nm), both of the dyads exhibited not only a porphyrin emission (605 nm) but also a phthalocyanine emission (ca. 700 nm), indicating the occurrence of intramolecular fluorescence resonance energy transfer (FRET) processes from the porphyrin donor to the phthalocyanine acceptor. The dyads can selectively bind Pb in the phthalocyanine core leading to a red shift of the phthalocyanine absorption and thus a decrease of spectral overlap between the porphyrin emission and phthalocyanine absorption, which in turn suppresses the intramolecular FRET. In addition, the binding of Pb can highly quench the emission of phthalocyanine by heavy-metal ion effects. The synergistic coupled functions endow the dyads with remarkable ratiometric fluorescent responses at two distinct wavelengths (F/F for 1 and F/F for 2). The emission intensity ratio increased as a linear function to the concentration of Pb in the range of 0-4.0 μM, whereas the detection limits were determined to be 3.4 × 10 and 2.2 × 10 M for 1 and 2, respectively. Furthermore, by comparative study of 1 and 2, the effects of distance and relative orientation between Pc and ZnPor fluorophores on the FRET efficiency and sensing performance were highlighted, which is helpful for further optimizing such FRET systems.

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Design of microfluidic fluorescent sensor arrays for real-time and synchronously visualized detection of multi-component heavy metal ions

Li,

Xu,

et al. 2024

Chemical Engineering Journal

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Metal Toxicology in Clinical, Forensic, and Chemical Pathology

Cited by 3 publications

References 46 publications

Metal Profiles in Autism Spectrum Disorders: A Crosstalk between Toxic and Essential Metals

Metal Profiles in Autism Spectrum Disorders: A Crosstalk between Toxic and Essential Metals

Ratiometric Fluorescent Detection of Pb²⁺ by FRET-Based Phthalocyanine-Porphyrin Dyads

Design of microfluidic fluorescent sensor arrays for real-time and synchronously visualized detection of multi-component heavy metal ions

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Metal Toxicology in Clinical, Forensic, and Chemical Pathology

Cited by 3 publications

References 46 publications

Metal Profiles in Autism Spectrum Disorders: A Crosstalk between Toxic and Essential Metals

Metal Profiles in Autism Spectrum Disorders: A Crosstalk between Toxic and Essential Metals

Ratiometric Fluorescent Detection of Pb2+ by FRET-Based Phthalocyanine-Porphyrin Dyads

Design of microfluidic fluorescent sensor arrays for real-time and synchronously visualized detection of multi-component heavy metal ions

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Ratiometric Fluorescent Detection of Pb²⁺ by FRET-Based Phthalocyanine-Porphyrin Dyads