Determination of δ9-tetrahydrocannabinol in human blood and saliva by high-performance liquid chromatography with amperometric detection

Marijuana Smoking: Factors That Influence the Bioavailability of Tetrahydrocannabinol

“…The results of several independent studies indicate that THC is present in saliva and that its concentration declines with time after marijuana smoking (Hawks 1984;Cross et al 1987;Maseda et al 1986;Thompson and Cone 1987). The presence of THC in saliva after marijuana smoking is not due to its secretion by the salivary glands.…”

Development of a simple and sensitive HPLC–UV method for the simultaneous determination of cannabidiol and Δ9-tetrahydrocannabinol in rat plasma

“…However, equipment and maintenance, as well as sample running costs are a considerable drawback of these methods [35,36]. For the detection of CBD and/or THC in human plasma, bioanalytical methods had been developed using radioactivity assays [37], high-performance liquid chromatography (HPLC)-UV detection [38], HPLC-electrochemical detection [39], gas chromatography-mass spectrometry (GC-MS) [40][41][42][43], and LC-MS [43,44]. However, issues of unspecific detection and/or high blood sampling volumes needed for the analysis preclude the use of these methods to conduct pharmacokinetic studies in rats.…”

Development and validation of a method for the quantitation of Δ9 tetrahydrocannabinol in human plasma by high performance liquid chromatography after solid-phase extraction

“…The use of more commonly available detectors was reserved to the electrochemical detectors (ED) [17][18][19][20][21]. Ultra violet detectors are used only in methods developed for the quantification of THC-COOH in urine [22,23].…”

“…Several methods for the quantification of THC and THC-COOH are already published [1,[4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23].…”