Determination of trimetazidine HCl by adsorptive stripping square-wave voltammetry at a glassy carbon electrode

Trimetazidine Revisited: A Comprehensive Review of the Pharmacological Effects and Analytical Techniques for the Determination of Trimetazidine

“…They are very rapid methods that have been applied successfully to trace measurements of important pharmaceuticals thanks to the high sensitivity and selectivity that they provide (Hart 1990; Özkan 2007; Özkan et al 2003; Smyth and Vos 1992; Uslu and Özkan 2007; Wang 2000). An adsorptive stripping square wave voltammetric method was described for the determination of TMZ in tablets and spiked urine samples based on measuring the single and sharp peak in acetate buffer at pH 5.0 (Ghoneim et al 2002). Adsorptive oxidation peak occurred at 0.75 V (vs. Ag/AgCl).…”

“…Cyclic voltammetric studies were also performed for the investigation of the process. The solution conditions, such as pH, nature of the buffer, and instrumental parameters, were optimized for the determination of TMZ in tablets and urine samples (Ghoneim et al 2002).…”

The Analytical Applications of Square Wave Voltammetry on Pharmaceutical Analysis

“…The adsorptive and electrochemical behavior of trimetazidine hydrochloride on a glassy carbon electrode were investigated in acetate buffer solution by using cyclic and square-wave voltammetry by Ghoneim et al [114]. Cyclic voltammetric studies indicated the oxidation of trimetazidine hydrochloride at the electrode surface through a single two-electron irreversible step and fundamentally controlled by adsorption.…”

Sensitive determination of trimetazidine in spiked human plasma by HPLC with fluorescence detection after pre-column derivatization with 9-fluorenylmethyl chloroformate

“…In addition, TMZ has been determined using spectrophotometric methods based on charge transfer complexes formation using, 2,3-dichloro-5,6-dicyanop-benzoquinone (DDQ), 7,7,8,8-tetracyano-quinodimethane (TCNQ), p-chloranil, and complexation with iron(III) chloride [10,11]. Other reported methods have been adopted for the analysis of TMZ in bulk or pharmaceutical dosage forms which include voltammetry and HPLC with UV detection [12][13][14][15]. With the exception of the HPLC-fluorescence procedure [7], all other analytical methods do not confer enough sensitivity for monitoring low TMZ levels in plasma.…”