Determination of ticarcillin epimers in plasma and urine with high-performance liquid chromatography

Li, Yinhua; Itoh, Tomoo; Tsuda, Yasuyuki; Ishida, Masato; Watanabe, Naoko; Shimada, Hideaki; Yamada, Hideo

doi:10.1016/s0378-4347(97)00123-0

Cited by 5 publications

(3 citation statements)

References 21 publications

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“…SPE was applied for sample preparation using Isolute TM -SAX 200 mg/3 mL cartridges for plasma samples and Isolute-SAX 100 mg/1 mL cartridges for urine samples [64].…”

Section: Chromatographic Conditions -Sample Preparationmentioning

confidence: 99%

Chromatographic analysis of penicillins in pharmaceutical formulations and biological fluids

Samanidou

Evaggelopoulou

Papadoyannis³

2006

J of Separation Science

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Natural penicillin (benzylpenicillin) is the oldest antibiotic observed by Alexander Fleming in 1928. To broaden its spectrum of activity, natural penicillin was modified, giving rise to a group of antibiotics under the name 'penicillins'. Although an increasing number of bacteria appear to be resistant to them, penicillins are used to treat a variety of bacterial infections including Gram-positive, Gram-negative aerobic and anaerobic bacteria. Consequently, they are widely used in human and veterinary medicine to prevent and treat diseases. This review covers the analytical methodologies, mainly chromatographic, employed to the penicillins determination in pharmaceutical formulations, biological fluids and in production-scale fermentations reported in the literature. Results of published assays are comparatively presented focusing on sample preparation regarding isolation and purification, chromatographic conditions and method validation. Information on chemical structure, spectrum of activity and action mechanism of common penicillins has also been given.

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“…SPE was applied for sample preparation using Isolute TM -SAX 200 mg/3 mL cartridges for plasma samples and Isolute-SAX 100 mg/1 mL cartridges for urine samples [64].…”

Section: Chromatographic Conditions -Sample Preparationmentioning

confidence: 99%

Chromatographic analysis of penicillins in pharmaceutical formulations and biological fluids

Samanidou

Evaggelopoulou

Papadoyannis³

2006

J of Separation Science

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“…The analytical range to be validated was chosen on the basis of the expected plasma concentrations of the studied drugs [5][6][7]11]. The calibration curve was done for each analyte in the biological sample.…”

Section: Linearitymentioning

confidence: 99%

“…Clinical trials showed its intravenous injection formula was effective in treating respiratory infections and the drug has been approved and is available in Japan [3]. The literature survey revealed that analytical methods reported for the estimation of pazufloxacin mesylate in human plasma include chemiluminescence flow injection [4] and HPLC methods [5][6][7]. No method has been reported for determination of pazufloxacin mesylate in human plasma with co-administered drugs by HPLC and densitometric TLC.…”

Section: Introductionmentioning

confidence: 99%

HPLC and Densitometric TLC Methods for Simultaneous Determination of Pazufloxacin with Some Co-Administered Drugs in Human Plasma

Abdallah¹

2012

J Chromat Separation Techniq

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Two chromatographic methods have been developed for determination of pazufloxacin in human plasma with two co-administered drugs, cefoperazone and sulbactam sodium. First method depends on reverse phase high performance liquid chromatography. The plasma sample was extracted using mixture of ethyl acetate and 15% perchloric acid. The method was linear over the concentration range 0.5 to 20 µg/ml, 1 to 30 µg/ml and 1 to 25 µg/ ml of pazufloxacin mesylate, cefoperazone and sulbactam sodium, respectively.The mobile phase used consist of methanol, 0.01 M sodium acetate buffer (pH adjusted to 3 using trifluoroacetic acid) in a ratio 20:80 and 0.5% TEA and flow rate 1 ml/min in isocratic mode and UV-detection at wavelength 240 nm. Second method depends on densitometric thin layer chromatography. The method was linear over concentration range 1 to 20 µg/ml, 6 to 24 µg/ml and 4 to 20 µg/ml of pazufloxacin mesylate, cefoperazone and sulbactam sodium, respectively. The mobile phase used consists of chloroform, methanol and ammonia in the ratio of (11:6:2, v/v/v). Densitometric analysis was carried out at wavelength 240 nm. The stability of pazufloxacin mesylate and the coadministered drugs in plasma was confirmed during three freeze-thaw cycles (−20°C).

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RP-HPLC separation of interconvertible rotamers of a 5-tetrahydroisoquinolin-6-yl-pyridin-3-yl acetic acid derivative and confirmation by VT NMR and DFT study

Chauthe

Sidduri

Reddy

et al. 2022

Journal of Pharmaceutical and Biomedical Analysis

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Determination of ticarcillin epimers in plasma and urine with high-performance liquid chromatography

Cited by 5 publications

References 21 publications

Chromatographic analysis of penicillins in pharmaceutical formulations and biological fluids

Chromatographic analysis of penicillins in pharmaceutical formulations and biological fluids

HPLC and Densitometric TLC Methods for Simultaneous Determination of Pazufloxacin with Some Co-Administered Drugs in Human Plasma

RP-HPLC separation of interconvertible rotamers of a 5-tetrahydroisoquinolin-6-yl-pyridin-3-yl acetic acid derivative and confirmation by VT NMR and DFT study

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