Two nanoparticles based potentiometric sensors were fabricated for the selective determination of gemifloxacin mesylate. The first sensor was based on the formation of molecularly imprinted polymer nanoparticles using methacrylic acid as a functional monomer, trimethylolpropane trimethacrylate as a crosslinker and azobisisobutyronitrile as the initiator. The second sensor was based on the use of Fe 3 O 4 magnetic nanoparticles as core shells for the molecularly imprinted polymer. The developed sensors showed high selectivity, stability and sensitivity with wide concentration ranges of 1×10 -3 -1×10 -8 mol L -1 and 1×10 -3 -1×10 -10 mol L -1 for sensors 1 and 2, respectively. They were efficiently applied for the determination of gemifloxacin mesylate in bulk, pharmaceutical tablets and spiked human plasma.

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New carbon paste electrode for pazufloxacin mesylate determination modified with MWCNTs/ TiO 2 /Chitosan nanocomposite was developed. It was based on the covalent linkage of chitosan to the MWCNTs/TiO 2 nanoparticle surface to enhance the sensor electrical properties, sensitivity and selectivity. The prepared nanocomposite was characterized by Fourier transform-Infrared, X-ray diffraction, Transmission electron microscope and Thermal gravimetric analysis. The sensor under optimal conditions exhibited high accuracy, precision and reproducibility with a stability of 123 days. It was efficiently applied for the determination of pazufloxacin mesylate in pure standard solution and spiked human plasma. It showed a linearity range of 1 × 10 −9 to 1 × 10 −3 mol L −1 with a correlation coefficient of 0.994 and a nernestian slope of 56.76 mV/concentration decade. The LOD was 4.8 × 10 −10 mol L −1 .