Determination of the Minimum Anesthetic Concentration and Cardiovascular Dose Response for Sevoflurane in Chickens During Controlled Ventilation

Naganobu, Kiyokazu; Fujisawa, Yutaka; Ohde, Hirotaka; Matsuda, Yoshiko; Sonoda, Tatsunobu; Ogawa, Hiroyuki

doi:10.1111/j.1532-950x.2000.00102.x

Cited by 46 publications

(40 citation statements)

References 22 publications

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“…When chickens were anesthetized with isoflurane or sevoflurane during controlled ventilation, there were dose-dependent decreases in arterial pressure but the heart rates did not vary. 10,11 In the case of ducks, Ludders et al 8 reported that neither the mean heart rate nor the mean arterial blood pressure varied significantly when anesthetized with 1.0 and 1.5 times the MAC of isoflurane during spontaneous ventilation. On the other hand, in another study, Ludders 6 reported that there was a significant dose-dependent increase in the heart rate when ducks were anesthetized with halothane during spontaneous ventilation.…”

Section: Brief Communicationmentioning

confidence: 98%

Minimum Anesthetic Concentration and Cardiovascular Dose–Response Relationship of Isoflurane in Cinereous Vultures (Aegypius monachus)

Kim

Lee²,

Suh³

et al. 2011

Journal of Zoo and Wildlife Medicine

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This study aimed to determine the minimum anesthetic concentration (MAC) and dose-related cardiovascular effects of isoflurane during controlled ventilation in cinereous vultures (Aegypius monachus). The MAC was determined for 10 cinereous vultures as the midpoint between the end-tidal isoflurane concentration that allows gross purposeful movement and that which prevents the movement in response to clamping a pedal digit. Immediately after the MAC was determined, the cardiovascular effects of isoflurane at 1.0, 1.5, and 2.0 times the MAC were investigated in seven of the 10 birds. The MAC of isoflurane for 10 cinereous vultures during controlled ventilation was 1.06 +/- 0.07% (mean +/- SD). When the isoflurane concentration was increased to 1.5 and 2.0 times the MAC, there was significant dose-dependent decrease in the arterial blood pressure. However, the heart rate did not change over a range of 1.0 to 2.0 times the MAC.

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Section: Brief Communicationmentioning

confidence: 98%

Minimum Anesthetic Concentration and Cardiovascular Dose–Response Relationship of Isoflurane in Cinereous Vultures (Aegypius monachus)

Kim

Lee²,

Suh³

et al. 2011

Journal of Zoo and Wildlife Medicine

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“…The sample number (12 per group) was calculated based on the published chicken sevoflurane MAD 2.2 ± 0.32% [10], a reduction of 20% in premedicated groups, and a power of 80%.…”

Section: Methodsmentioning

confidence: 99%

“…Among the different inhalant anaesthetics, sevoflurane has several advantages, such as a lower blood-gas partition coefficient and a non-pungent odour, and it also provides rapid induction and recovery [9,10]. Both sevoflurane and isoflurane have been proven safe for use in parrots [11,12].…”

Section: Introductionmentioning

confidence: 99%

The effect of premedication with ketamine, alone or with diazepam, on anaesthesia with sevoflurane in parrots (Amazona aestiva)

et al. 2013

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BackgroundPremedication is rarely used in avian species. The aim of this study was to evaluate the effect of premedication on the quality of sevoflurane induction and anaesthesia in parrots. We hypothesised that premedication would facilitate handling and decrease the minimum anaesthetic dose (MAD). Thirty-six adult parrots were randomly distributed in three groups: group S (n = 12) was premedicated with NaCl 0.9%; group KS (n = 12) was premedicated with 10 mg.kg-1 ketamine; and group KDS (n = 12) was premedicated with 10 mg.kg-1 ketamine and 0.5 mg.kg-1 diazepam, delivered intramuscularly. After induction using 4.5% sevoflurane introduced through a facemask, the MAD was determined for each animal. The heart rate (HR), respiratory rate (RR), systolic arterial blood pressure (SAP), and cloacal temperature (CT) were recorded before premedication (T0), 15 minutes after premedication (T1), and after MAD determination (T2). Arterial blood gas analyses were performed at T0 and T2. The quality of anaesthesia was evaluated using subjective scales based on animal behaviour and handling during induction, maintenance, and recovery. Statistical analyses were performed using analysis of variance or Kruskal-Wallis tests followed by Tukey’s or Dunn’s tests.ResultsThe minimal anaesthetic doses obtained were 2.4 ± 0.37%, 1.7 ± 0.39%, and 1.3 ± 0.32% for groups S, KS, and KDS, respectively. There were no differences in HR, RR, or CT among groups, but SAP was significantly lower in group S. Sedation was observed in both the premedicated S-KS and S-KDS groups. There were no differences in the quality of intubation and recovery from anaesthesia among the three groups, although the induction time was significantly shorter in the pre-medicated groups, and the KS group showed less muscle relaxation.ConclusionsKetamine alone or the ketamine/diazepam combination decreased the MAD of sevoflurane in parrots (Amazona aestiva). Ketamine alone or in combination with diazepam promoted a good quality of sedation, which improved handling and reduced the stress of the birds. All protocols provided safe anaesthesia in this avian species.

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“…Por outro lado, o isofluorano causa uma diminuição na pressão arterial de forma dose dependente (GOEZ; HAHN; KELLEY, 1990;GREENLEES et al, 1990;LUDDERS;RODE, 1990;LUDDERS;MITCHELL, 1989). O sevofluorano causou a mesma diminuição da pressão arterial durante a anestesia em ventilação controlada em galinha (NOGANOBU et al, 2000). A cetamina comercial é uma mistura racêmica contendo dois enantiômeros óticos, R(-) e S(+) e o conservante cloreto de benzetônio.…”

Section: Revisão De Literatura 39unclassified

“…No nosso estudo, optou-se pelo pinçamento interdigital, da mesma forma proposta por Ludders, Mitchel e Schaeffer (1988) e seguido por todos os demais autores que trabalham com DAM em aves: Curro, Brunson e Paul-Murphy (1994), Guimarães et al (2000), Nicolau et al (2002), Noganobu et al (2000).…”

Section: Frequência Cardíacaunclassified

Efeito da pré-medicação em papagaios (Amazona aestiva), com cloridrato de cetamina isolado ou associado ao diazepam, sobre a indução e anestesia com sevofluorano

Paula¹,

Veras²

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Autorizo a reprodução parcial ou total desta obra, para fins acadêmicos, desde que citada a fonte. Ao secretário do Curso de Pós-Graduação -Área de Cirurgia, Belarmino Ney Pereira, pelo apoio e boa vontade dispensados a todos os pós-graduandos. DADOS INTERNACIONAIS DE CATALOGAÇÃO-NA-PUBLICAÇÃO( FOLHA DE AVALIAÇÃOAos meus colegas da pós-graduação, agradeço a convivência e a troca de conhecimentos.A todos meus amigos, sempre presentes nas horas certas e principalmente nas mais incertas.Ao Conselho Nacional de Desenvolvimento Científico e Tecnológico pelo apoio financeiro. Quinze minutos após a pré-medicação, a indução foi realizada por meio de máscara facial conectada a um circuito sem reinalação, usando 4,5% de sevofluorano em 100% de oxigênio, com um fluxo de 1,5L. Tanto os efeitos cardiovasculares e respiratórios, bem como, a qualidade da pré-medicação, indução e recuperação da anestesia foram avaliadas. A Dose anestésica mínima obtida neste estudo foi de 2.4 ± 0.37%, 1.7 ± 0.39%, e 1.3 ± 0.32% para os grupos I, II e III respectivamente. Foi concluído que a cetamina isolada ou cetamina/diazepam diminuem consideravelmente a dose anestésica mínima em papagaios. A cetamina isolada ou em associação, promoveu uma boa qualidade de sedação, permitindo uma melhor indução da anestesia quando comparada a indução com o agente inalatório. Tanto a cetamina isolada quanto a associação, mostraram-se seguras, não alterando as funções cardiovasculares, a oxigenação ou ventilação, podendo ser utilizados com sucesso nesta espécie. Além disto, a anestesia com o sevofluorano foi considerada segura para esta espécie em todos os protocolos estudados. Although pre-medication is commonly used in mammals, it is rarely used in avian species. The aim of this study was to evaluate the effect of pre-medication in the induction and anesthesia with sevoflurane in parrots. Thirty-six adults animals were utilized from Tietê ecologic park. The animals were randomically distributed in three groups: group I (n = 12), was pre-medicated with NaCl0.9% as a placebo, group II (n = 12), with ketamine 10 mg.kg -1 and group III (n = 12), with ketamine 10mg.kg -1 and diazepam 0.5mg.kg -1 , intramuscularly. Fifteen minutes after pre-medication, the induction was accomplished with a facial mask connected to a non rebreathing circuit using 4.5% of sevoflurane in 100% oxygen with a flow rate of 1.5L. The cardiovascular and respiratory effects were evaluated as well as the quality of premedication, induction and recovery of anesthesia. The minimal anesthetic concentration obtained at this study was 2.4 ± 0.37%, 1.7 ± 0.39%, and 1.3 ± 0.32% for group I, II and III respectively. It was concluded that ketamine alone or ketamine/diazepam consider decreased the DAM of sevofluorano in parrots.ketamine alone or in association, promoted a good quality of sedation allowing better induction of anesthesia when compared with the induction with inhalant agent. Even ketamine alone or the association were considered a safe procedure, not changing cardiovascular, oxygenation ...

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Determination of the Minimum Anesthetic Concentration and Cardiovascular Dose Response for Sevoflurane in Chickens During Controlled Ventilation

Abstract: The minimum anesthetic concentration for sevoflurane in chickens was within the range of minimum alveolar concentration reported in mammals. When the concentration of sevoflurane is increased during controlled ventilation in chickens, decrease in arterial pressure should be expected.

Cited by 46 publications

References 22 publications

Minimum Anesthetic Concentration and Cardiovascular Dose–Response Relationship of Isoflurane in Cinereous Vultures (Aegypius monachus)

Minimum Anesthetic Concentration and Cardiovascular Dose–Response Relationship of Isoflurane in Cinereous Vultures (Aegypius monachus)

The effect of premedication with ketamine, alone or with diazepam, on anaesthesia with sevoflurane in parrots (Amazona aestiva)

Efeito da pré-medicação em papagaios (Amazona aestiva), com cloridrato de cetamina isolado ou associado ao diazepam, sobre a indução e anestesia com sevofluorano

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