Determination of the bioavailability of zinc oxide nanoparticles using ICP-AES and associated toxicity

Sudhakaran, Sreeja; Ss, Athira; Siliveri, Suresh; Hk, Varma; Mohanan, P.V.

doi:10.1016/j.colsurfb.2019.110767

Cited by 18 publications

(4 citation statements)

References 25 publications

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“…There might be multiple factors impacting the increased level of cholesterol and its derivatives in microsomes, as a result of zinc supplementation. Higher cholesterol levels in animals resulting from zinc administration have also been shown in other studies [50].…”

Section: Discussionsupporting

confidence: 78%

The Influence of Supplementation with Zinc in Micro and Nano Forms on the Metabolism of Fatty Acids in Livers of Rats with Breast Cancer

et al. 2021

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The aim of this study was to investigate the effect of zinc supplementation (in the form of nano or microparticles) on the profile and metabolism of fatty acids in the liver microsomes of rats with induced breast cancer. The activity of desaturases (Δ5, Δ6, Δ9) and the level of cholesterol and its oxidized derivatives were measured. The aim of this study was also to determine the effect of various forms of zinc supplements on rats that were on 5-, 12- and 15-hydroxyeicosatetraenoic (5-, 12- and 15-HETE) and hydroxyoctadecadienoic (HODE) acids, and the level of prostaglandin E2 (PGE2). Female Spraque-Dawley rats (n = 24) were divided into 2 groups that were supplemented with zinc in the micro form (342 nm) or nano form (99 nm) particles, respectively, and a group with a standard diet (control group). All animals received 7,12-dimethylbenz[a]anthracene twice for the induction of breast cancer. Dietary nano-Zn supplementation increased vaccenic acid content (p = 0.032) and decreased Δ6-desaturase activity (p = 0.006), whereas micro-Zn increased cholesterol (p = 0.006), ∑COPs (total cholesterol-oxidation products) (p = 0.019) and PGE2 (p = 0.028) content. Dietary enrichment with Zn microparticles resulted in lower concentrations of the metabolites 15-, 12- and 5-HETE and HODE. Our study indicates that the effect of zinc supplementation on the metabolism of fatty acids in the liver microsomes under neoplastic conditions depends on the form in which it is administered.

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Section: Discussionsupporting

confidence: 78%

The Influence of Supplementation with Zinc in Micro and Nano Forms on the Metabolism of Fatty Acids in Livers of Rats with Breast Cancer

et al. 2021

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“…Studies have shown that their toxicity is dose dependent. Sudhakaran et al 111 obtained spherical ZnO-NPs with diameters of ~43 nm with a wet chemical method. Subsequently, ZnO-NPs were administered to healthy adult Wistar rats through intravenous and intraperitoneal routes (10 mg/kg).…”

Section: Toxicity and Anticancer Properties Toxicity Mechanisms And Rmentioning

confidence: 99%

<p>Enhancing ZnO-NP Antibacterial and Osteogenesis Properties in Orthopedic Applications: A Review</p>

Li¹,

Yang²,

Qing³

et al. 2020

IJN

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Prosthesis-associated infections and aseptic loosening are major causes of implant failure. There is an urgent need to improve the antibacterial ability and osseointegration of orthopedic implants. Zinc oxide nanoparticles (ZnO-NPs) are a common type of zinccontaining metal oxide nanoparticles that have been widely studied in many fields, such as food packaging, pollution treatment, and biomedicine. The ZnO-NPs have low toxicity and good biological functions, as well as antibacterial, anticancer, and osteogenic capabilities. Furthermore, ZnO-NPs can be easily obtained through various methods. Among them, green preparation methods can improve the bioactivity of ZnO-NPs and strengthen their potential application in the biological field. This review discusses the antibacterial abilities of ZnO-NPs, including mechanisms and influencing factors. The toxicity and shortcomings of anticancer applications are summarized. Furthermore, osteogenic mechanisms and synergy with other materials are introduced. Green preparation methods are also briefly reviewed.

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“…Various antitoxic strategies, involving coatings and surface treatments, are emerging to decrease the harmful results while maintaining the favorable properties of MONPs [180]. Mohanan et al recommends adopting surface functionalization strategies for reducing toxic response of ZnO nanoparticles in various applications [181]. Different strategies of surface modification and functionalization of colloidal ZnO nanoparticles have been reported to lower their toxicity [182].…”

Section: Fluorescence Detection Of Transition Metal Oxide Nanoparticlesmentioning

confidence: 99%

Current State of Laser-Induced Fluorescence Spectroscopy for Designing Biochemical Sensors

Taylor

Lai

2021

Chemosensors

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Laser-induced fluorescence (LIF) has been a valuable analytical technique since the 1970s that has only been made more useful through advances in other scientific fields such as biochemistry. Moreover, advances in laser and detector technology have seen a decrease in LIF detector costs and an increase in their ease of use. These changes have allowed for LIF technology to be widely adopted for various sensor designs in combination with advanced instruments. With advances in biochemistry necessitating the detection of complex metabolites, labelling with fluorescent chemical reagents may be necessary to improve detection sensitivity. Furthermore, advances made in fluorescent labeling technologies have allowed for the use of LIF in the detection of nanoparticles as well as for imaging techniques using nanoparticles as signal amplifiers. This technology has become invaluable in the detection of environmental pollutants, monitoring of biological metabolites, biological imaging, and cancer diagnosis, making it one of the most valuable analytical science techniques currently available.

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Determination of the bioavailability of zinc oxide nanoparticles using ICP-AES and associated toxicity

Cited by 18 publications

References 25 publications

The Influence of Supplementation with Zinc in Micro and Nano Forms on the Metabolism of Fatty Acids in Livers of Rats with Breast Cancer

The Influence of Supplementation with Zinc in Micro and Nano Forms on the Metabolism of Fatty Acids in Livers of Rats with Breast Cancer

<p>Enhancing ZnO-NP Antibacterial and Osteogenesis Properties in Orthopedic Applications: A Review</p>

Current State of Laser-Induced Fluorescence Spectroscopy for Designing Biochemical Sensors

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