Determination of sulfametoxazole, sulfadiazine and associated compounds in pharmaceutical preparations by capillary zone electrophoresis

Nevado, J. J. Berzas; Castañeda, Gregorio; Bernardo, Francisco Javier Guzmán

doi:10.1016/s0021-9673(01)00722-1

Cited by 46 publications

(28 citation statements)

References 11 publications

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“…Furthermore, the detection limit of the proposed method (0.8 µg/L) is lower than the previously reported methods. [5][6]10,12,15,[17][18][19][20] The main advantages of the method are simplicity, rejection of matrix constituents, high sensitivity, low cost, speed of analysis and applicability for various real samples (tablet, milk and urine samples). …”

Section: Conculsionmentioning

confidence: 99%

“…Several analytical procedures for the determination of sulfadiazine have been reported in the literature. Among them are reversed phase high performance liquid chromatography coupled with on-line atmospheric pressure chemical ionization mass spectrometry (HPLC/APCI-MS), 4 capillary zone electrophoresis, 5 18 and FIA system with amperometric detection. 19 However, most of them either require complicated and ex-pensive instruments, 4,[8][9][10][11]15,16 or are time consuming, 4,6,[12][13][14] or have high detection limit.…”

Section: Introductionmentioning

confidence: 99%

“…19 However, most of them either require complicated and ex-pensive instruments, 4,[8][9][10][11]15,16 or are time consuming, 4,6,[12][13][14] or have high detection limit. 5,7,8,14,15,18 Therefore, the need for a sensitive, simple and reliable method for the determination of sulfadiazine is well recognized. Flame atomic absorption spectroscopy is a versatile, simple and high speed instrument for direct determination of metal ions, [20][21][22][23][24][25] but its use in indirect determination of nonmetallic anions and drugs is limited.…”

Section: Introductionmentioning

confidence: 99%

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Indirect Determination of Sulfadiazine by Cloud Point Extraction/Flow Injection‐Flame Atomic Absorption (CPE/FI‐FAAS) Spectrometry

Dadfarnia

Hajishabani

Rad

2011

J Chinese Chemical Soc

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An indirect simple and rapid cloud point extraction is proposed for separation and preconcentration of sulfadiazine and its determination by flow injection-flame atomic absorption spectroscopy (FI-FAAS). The sulfadiazine from 35 mL of solution was readily converted to silver sulfadiazine upon addition of silver nitrate (9.7 × 10 -5 mol/L). Then, Triton X-114 a non ionic surfactant was added and the solution was heated to 60°C. At this stage, two separate phases was formed and silver sulfadiazine enters the surfactant rich phase of non-ionic micelles of Triton X-114. The surfactant-rich phase (~50 µL) was then separated and diluted to 300 µL with acidic methanol. The concentration of silver in the surfactant-rich phase which is proportional to the concentration of sulfadiazine in sample solution was determined by FI-FAAS. The parameters affecting extraction and separation were optimized. Under the optimum conditions (i.e. pH 2-10, silver concentration (9.7 × 10 -5 mol/L), Triton X-114 (0.075% v/v) and temperature 60°C) a preconcentration factor of 117 and a relative standard deviation of 4.9% at 37 mg L -1 of sulfadiazine was obtained. The method was successfully applied to analysis of milk, urine and tablet samples and accuracy was determined by recovery experiments.

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Section: Conculsionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Indirect Determination of Sulfadiazine by Cloud Point Extraction/Flow Injection‐Flame Atomic Absorption (CPE/FI‐FAAS) Spectrometry

Dadfarnia

Hajishabani

Rad

2011

J Chinese Chemical Soc

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“…De maneira geral, as metodologias sugeridas para identificação e quantificação de fármacos correspondem a técnicas espectroscópicas e cromatográficas, respectivamente 10 . Dentre as novas metodologias propostas para análise desta associação, destacam-se técnicas fundamentadas em cromatografia líquida 11,12 e eletroforese capilar 13 . Recentemente, uma metodologia espectroscópica multivariada foi proposta para a quantificação de misturas de sulfanilamidas por espectroscopia UV-Vis, metodologia que permitiu a obtenção de erros de previsão inferiores a 11% 14 .…”

Section: Introductionunclassified

Determinação de misturas de sulfametoxazol e trimetoprima por espectroscopia eletrônica multivariada

Cordeiro¹,

Peralta‐Zamora²,

Nagata³

et al. 2008

Quím. Nova

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Recebido em 21/12/06; aceito em 2/8/07; publicado na web em 19/12/07 DETERMINATION OF SULFAMETHOXAZOLE AND TRIMETHOPRIM MIXTURES BY MULTIVARIATE ELECTRONIC SPECTROSCOPY. In this work a multivariate spectroscopic methodology is proposed for quantitative determination of sulfamethoxazole and trimethoprim in pharmaceutical associations. The multivariate model was developed by partial least-squares regression, using twenty synthetic mixtures and the spectral region between 190 and 350 nm. In the validation stage, which involved the analysis of five synthetic mixtures, prediction errors lower that 3% were observed. The predictive capacity of the multivariate models is seriously affected by spectral changes induced by pH variations, a fact that acquires a great significance in the analysis of real samples (pharmaceuticals) that contain chemical additives.Keywords: sulfamethoxazole-trimethoprim; multivariate calibration; electronic spectroscopy. INTRODUÇÃOA Química Analítica enfrenta com bastante freqüência o desafio proveniente das mais variadas áreas da ciência, sempre com o objetivo de contribuir com o estabelecimento de metodologias analíticas cada vez mais sensíveis, seletivas, confiáveis e de menor custo.Por motivos óbvios, o controle de qualidade de produtos farmacêuticos adquire grande importância, não apenas para avalizar os processos de produção, mas principalmente para assegurar o cumprimento de padrões qualitativos e quantitativos que garantam a eficácia e segurança dos medicamentos. Deste ponto de vista, a disponibilização de metodologias analíticas confiáveis e, se possí-vel, rápidas e de baixo custo, mostra-se extremamente importante, particularmente no Brasil, que ocupa a décima colocação no ranking dos maiores consumidores de medicamentos no mundo 1 . Na área de produção de medicamentos, a associação de dois ou mais fármacos é uma prática bastante freqüente, uma vez que pode otimizar o tratamento e melhorar a adesão do paciente à terapia prescrita. Nestes casos, a quantificação de uma espécie na presença de excipientes e princípios auxiliares pode ser bastante complexa, o que geralmente obriga a utilização de técnicas cromatográficas 2 , reconhecidamente demoradas e dispendiosas. A espectroscopia eletrônica (UV-Vis) apresenta um conjunto de características que favorecem sua participação em rotinas de análise química. Dentre outras, é possível destacar sua simplicidade operacional, elevada velocidade analítica, baixo custo e possibilidades de uso em sistemas de controle on-line 3,4 . Infelizmente, os freqüentes problemas de interferência espectral observados na espectroscopia UV-Vis representam limitações intransponíveis para as metodologias convencionais de calibração, o que inviabiliza a consolidação da técnica como ferramenta de controle.Nos últimos anos, a calibração multivariada tem sido utilizada com sucesso no estabelecimento de metodologias analíticas fundamentadas em espectroscopia UV-Vis 5-7 . De maneira geral, observa-se que aproximações multivariadas permitem explorar toda a informação forne...

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“…Some papers have been published, using mainly UV [21][22][23] or amperometric detection [24], applying the CZE mode [25][26][27][28][29] or micellar EKC (MEKC) [27,[30][31][32] in different matrices such as pharmaceutical compounds, biological fluids, or food of animal origin. The simultaneous determination of the combinations sulfamethoxazole (SMX)-TMP and sulfadiazine (SDZ)-TMP has been also carried out in pharmaceutical preparations by CZE [28]. The coupling of CE-MS for quantification purposes is gaining importance in the last few years, showing recently great potential in the determination of pesticides [33][34][35][36][37] and antibiotics [38,39].…”

Section: Introductionmentioning

confidence: 99%

Analytical methods for multiresidue determination of sulfonamides and trimethoprim in meat and ground water samples by CE‐MS and CE‐MS/MS

2007

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This paper presents two methods based on CZE-MS detection and CZE-MS/MS detection developed for the multiresidue determination of ten sulfonamides (sulfapyridine, sulfadoxin, sulfamethazine, sulfadimethoxine, sulfameter, sulfamerazine, sulfachlorpyridazine, sulfadiazine, sulfamethoxazole, and sulfamethizole) and a potentiator, trimethoprim (TMP), whose contents are regulated by the EU Council Regulation no. 2377/90 in animal edible tissues. Experimental designs were employed to optimize the electrospray conditions. MS/MS experiments using an IT as analyzer operating in multiple reaction monitoring (MRM) mode were carried out to achieve the minimum number of points according to the 2002/657/EC European Decision for unambiguous identification. The proposed procedures have been compared in terms of the performance characteristics and trueness. The limits of detection and quantification were in all cases lower than the maximum residue limits legislated for these compounds and the recoveries were satisfactory, being possible the application for their monitoring in foodstuff of animal origin and in environmental samples, allowing the determination of sulfonamides and TMP residues in meat and in superficial water in the low microg/L range.

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Determination of sulfametoxazole, sulfadiazine and associated compounds in pharmaceutical preparations by capillary zone electrophoresis

Cited by 46 publications

References 11 publications

Indirect Determination of Sulfadiazine by Cloud Point Extraction/Flow Injection‐Flame Atomic Absorption (CPE/FI‐FAAS) Spectrometry

Indirect Determination of Sulfadiazine by Cloud Point Extraction/Flow Injection‐Flame Atomic Absorption (CPE/FI‐FAAS) Spectrometry

Determinação de misturas de sulfametoxazol e trimetoprima por espectroscopia eletrônica multivariada

Analytical methods for multiresidue determination of sulfonamides and trimethoprim in meat and ground water samples by CE‐MS and CE‐MS/MS

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