“…Several analytical procedures for the determination of SDZ have been reported in the literature. Among them are reversed phase high performance liquid chromatography coupled with on-line atmospheric pressure chemical ionization mass spectrometry (HPLC,APCI-MS) (Combs et al,1999), cloud point extraction /flow injection-flame atomic absorption (CPE/FI-FAAS) spectrometry (Dadfarnia et al, 2011), capillary zone electrophoresis (Berzas et al, 2001), inductively coupled plasma-atomic emission spectroscopy (ICP-AES) (Qi-Oi et al, 2010), liquid chromatography (Valentina et al, 2009), UV-spectrophotometry (Kotha-cota et al, 2011), immunochromatographic assay (Wang et al, 2007), flow injection chemiluminescence (Liu et al, 2007) , ionselective electrode (Ayman et al, 2009). However, most of them suggest that the quantification of SDz in any matrix requires elaborate and sophisticated instruments which may or may not be available in every laboratory, others are time consuming or have high detection limit.…”