2014
DOI: 10.1590/s1676-24442014000100002
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Determination of serum lithium: comparison between atomic emission and absorption spectrometry methods

Abstract: Introduction: The therapeutic monitoring of lithium, through concentration measurements, is important for individual dose adjustment, as a marker of treatment adherence and to prevent poisoning and side effects. Objectives: Validate and compare two methods-atomic emission and atomic absorption-for the determination of lithium in serum samples. Methodology: Parameters such as specificity, precision, accuracy, limit of detection (LOD) and linearity were considered. The atomic absorption spectrometer was used, op… Show more

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Cited by 5 publications
(3 citation statements)
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“…Therefore, the matrix effect observed was minimal. Santo et al have reported of the absence of a matrix effect between serum and aqueous media, which is similar to our findings [7]. The absence of a significant matrix effect is also evident as the two slopes of the lithium concentration verses response plots are similar in aqueous solution (Figure 1) and serum solution (Figure 2).…”
Section: Discussionsupporting
confidence: 92%
See 1 more Smart Citation
“…Therefore, the matrix effect observed was minimal. Santo et al have reported of the absence of a matrix effect between serum and aqueous media, which is similar to our findings [7]. The absence of a significant matrix effect is also evident as the two slopes of the lithium concentration verses response plots are similar in aqueous solution (Figure 1) and serum solution (Figure 2).…”
Section: Discussionsupporting
confidence: 92%
“…Many methods are employed to determine the serum lithium concentrations. As reported in literature, photometric methods such as flame photometry, flame atomic absorption spectrophotometry and colorimetry are widely used, while ion-selective electrodes are also used to determine lithium concentrations [4][5][6][7]. Among these methods flame photometry is regarded as a simple, rapid and cost-effective method.…”
Section: Introductionmentioning
confidence: 99%
“…No differences were observed between the concentrations of lithium ions in men and women, unlike another study which found a higher correlation between the concentrations of lithium in saliva and serum in women [ 29 ]. In general, the concentration of lithium in saliva is about 2-3 times higher than in serum [ 40 , 41 ]. This can be explained by the slower removal of lithium ions from saliva than from serum.…”
Section: Determination Of Lithium Level In Salivamentioning
confidence: 99%