Improving lithium carbonate therapeutics by pegylated liposomal technology: an in vivo study

Hosseini, Yasaman; Alavi, Seyed Ebrahim; Akbarzadeh, Azim; Heidarinasab, Amir

doi:10.1007/s00580-015-2172-2

Cited by 9 publications

(3 citation statements)

References 32 publications

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“…The mean particle size and the morphology of the liposomes were determined using laser particle size analysis and SEM imaging, respectively 75 . Also, drug entrapment efficiency was evaluated using dialysis method.…”

Section: Methodsmentioning

confidence: 99%

Nasal delivery of donepezil HCl-loaded hydrogels for the treatment of Alzheimer’s disease

Harthi

Alavi

Radwan

et al. 2019

Sci Rep

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This study aims to prepare, characterize and evaluate the pharmacokinetics of liposomal donepezil HCl (LDH) dispersed into thiolated chitosan hydrogel (TCH) in rabbits. Various hydrogels including TCH were prepared, and after characterization, TCH was selected for subsequent evaluations, due to the promising results. TCH was then incorporated with LDH prepared by reverse phase evaporation method. The hydrogel was characterized using scanning electron microscope, dialysis membrane technique, and ultra-performance liquid chromatography methods. The optimized resultant was then evaluated in terms of pharmacokinetics in an in vivo environment. The mean size of LDH and drug entrapment efficiency were 438.7 ± 28.3 nm and 62.5% ± 0.6, respectively. The controlled drug release pattern results showed that the half-life of the loaded drug was approximately 3.5 h. Liposomal hydrogel and free liposomes were more stable at 4 °C compared to those in 20 °C. The pharmacokinetics study in the rabbit showed that the optimized hydrogel increased the mean peak drug concentration and area under the curve by 46% and 39%, respectively, through nasal route compared to the oral tablets of DH. Moreover, intranasal delivery of DH through liposomal hydrogel increased the mean brain content of the drug by 107% compared to the oral DH tablets. The results suggested that liposomes dispersed into TCH is a promising device for the nasal delivery of DH and can be considered for the treatment of Alzheimer’s disease.

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Section: Methodsmentioning

confidence: 99%

Nasal delivery of donepezil HCl-loaded hydrogels for the treatment of Alzheimer’s disease

Harthi

Alavi

Radwan

et al. 2019

Sci Rep

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“…In addition, nanosized lithium citrate induces apoptosis, whereas nanoparticles of lithium carbonate induce apoptosis and autophagic cell death of HCC cells [ 22 ]. Liposomal lithium carbonate nanostructures have a longer half-life, equal efficacy, and better therapeutic dose maintenance in blood compared to their standard-sized counterparts for bipolar disorder treatment [ 193 ].…”

Section: Trends In the Administration Of Lithiummentioning

confidence: 99%

Lithium: A Promising Anticancer Agent

Villegas-Vázquez

Quintas-Granados

Cortés

et al. 2023

Life

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Lithium is a therapeutic cation used to treat bipolar disorders but also has some important features as an anti-cancer agent. In this review, we provide a general overview of lithium, from its transport into cells, to its innovative administration forms, and based on genomic, transcriptomic, and proteomic data. Lithium formulations such as lithium acetoacetate (LiAcAc), lithium chloride (LiCl), lithium citrate (Li3C6H5O7), and lithium carbonate (Li2CO3) induce apoptosis, autophagy, and inhibition of tumor growth and also participate in the regulation of tumor proliferation, tumor invasion, and metastasis and cell cycle arrest. Moreover, lithium is synergistic with standard cancer therapies, enhancing their anti-tumor effects. In addition, lithium has a neuroprotective role in cancer patients, by improving their quality of life. Interestingly, nano-sized lithium enhances its anti-tumor activities and protects vital organs from the damage caused by lipid peroxidation during tumor development. However, these potential therapeutic activities of lithium depend on various factors, such as the nature and aggressiveness of the tumor, the type of lithium salt, and its form of administration and dosage. Since lithium has been used to treat bipolar disorder, the current study provides an overview of its role in medicine and how this has changed. This review also highlights the importance of this repurposed drug, which appears to have therapeutic cancer potential, and underlines its molecular mechanisms.

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“…Hereabouts, this section comprises the advantages and disadvantages of nano therapy subsisted in psychiatric treatment and the underlying mechanisms of disease pathogenesis also outlined 94 . It evidenced 95 that the accomplishment of nanodevices 95 and nanotools 96 in nanotherapy is an excellent approach for correct diagnosis and efficient therapy 97 . Consequently, the nanomaterials possess an exceptional potential and proficiency for molecular/nano-scale interactions, therefore at the nanoscale, it must incorporate with theranostics and therapeutics for the diagnosis and repair of degraded neurons, cells, and tissues 98 .…”

Section: The Monitoring Of the Drug Release Vivo mentioning

confidence: 99%

Review of nanotheranostics for molecular mechanisms underlying psychiatric disorders and commensurate nanotherapeutics for neuropsychiatry: The mind knockout

Kumar¹,

Chhikara²,

Gulia³

et al. 2021

Nanotheranostics

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Bio-neuronal led psychiatric abnormalities transpired by the loss of neuronal structure and function (neurodegeneration), pro-inflammatory cytokines, microglial dysfunction, altered neurotransmission, toxicants, serotonin deficiency, kynurenine pathway, and excessively produced neurotoxic substances. These uncontrolled happenings in the etiology of psychiatric disorders initiate further changes in neurotransmitter metabolism, pathologic microglial, cell activation, and impaired neuroplasticity. Inflammatory cytokines, the outcome of dysfunctional mitochondria, dysregulation of the immune system, and under stress functions of the brain are leading biochemical factors for depression and anxiety. Nanoscale drug delivery platforms, inexpensive diagnostics using nanomaterials, nano-scale imaging technologies, and ligand-conjugated nanocrystals used for elucidating the molecular mechanisms and foremost cellular communications liable for such disorders are highly capable features to study for efficient diagnosis and therapy of the mental illness. These theranostic tools made up of multifunctional nanomaterials have the potential for effective and accurate diagnosis, imaging of psychiatric disorders, and are at the forefront of leading technologies in nanotheranostics openings field as they can collectively and efficiently target the stimulated territories of the cerebellum (cells and tissues) through molecular-scale interactions with higher bioavailability, and bio-accessibility. Specifically, the nanoplatforms based neurological changes are playing a significant role in the diagnosis of psychiatric disorders and portraying the routes of functional restoration of mental disorders by newer imaging tools at nano-level in all directions. Because of these nanotherapeutic platforms, the molecules of nanomedicine can penetrate the Blood-Brain Barrier with an increased half-life of drug molecules. The discoveries in nanotheranostics and nanotherapeutics inbuilt unique multi-functionalities are providing the best multiplicities of novel nanotherapeutic potentialities with no toxicity concerns at the level of nano range.

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Improving lithium carbonate therapeutics by pegylated liposomal technology: an in vivo study

Cited by 9 publications

References 32 publications

Nasal delivery of donepezil HCl-loaded hydrogels for the treatment of Alzheimer’s disease

Nasal delivery of donepezil HCl-loaded hydrogels for the treatment of Alzheimer’s disease

Lithium: A Promising Anticancer Agent

Review of nanotheranostics for molecular mechanisms underlying psychiatric disorders and commensurate nanotherapeutics for neuropsychiatry: The mind knockout

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