Determination of Prothrombin

Quick, Armand J.

doi:10.3181/00379727-42-11052

Cited by 50 publications

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“…PT measures the formation of the fibrin clot through the activity of the extrinsic and common coagulation pathways, which involve the interaction of tissue factor and activated FVII, in addition to FX and FV, prothrombin and fibrinogen [25]. The test is based on plasma recalcification in the presence of tissue factor [26].…”

Section: Discussionmentioning

confidence: 99%

Effects of exposure to air pollution on blood coagulation

Baccarelli

Zanobetti²,

Martinelli

et al. 2007

Journal of Thrombosis and Haemostasis

197

130

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Summary. Background: Consistent evidence has indicated that air pollution increases the risk of cardiovascular diseases. The underlying mechanisms linking air pollutants to increased cardiovascular risk are unclear. Objectives: We investigated the association between the pollution levels and changes in such global coagulation tests as the prothrombin time (PT) and the activated partial thromboplastin time (APTT) in 1218 normal subjects from the Lombardia Region, Italy. Plasma fibrinogen and naturally occurring anticoagulant proteins were also evaluated. Methods: Hourly concentrations of particulate (PM 10 ) and gaseous pollutants (CO, NO 2 , SO 2 , and O 3 ) were obtained from 53 monitoring sites covering the study area. Generalized additive models were applied to compute standardized regression coefficients controlled for age, gender, body mass index, smoking, alcohol, hormone use, temperature, day of the year, and long-term trends. Results: The PT became shorter with higher ambient air concentrations at the time of the study of PM 10 (coefficient ¼ )0.06; P < 0.05), CO (coefficient ¼ )0.11; P < 0.001) and NO 2 (coefficient ¼ )0.06; P < 0.05). In the 30 days before blood sampling, the PT was also negatively associated with the average PM 10 (coefficient ¼ )0.08; P < 0.05) and NO 2 (coefficient ¼ )0.08; P < 0.05). No association was found between the APTT and air pollutant levels. In addition, no consistent relations with air pollution were found for fibrinogen, antithrombin, protein C and protein S. Conclusions: This investigation shows that air pollution is associated with changes in the global coagulation function, suggesting a tendency towards hypercoagulability after short-term exposure to air pollution. Whether these changes contribute to trigger cardiovascular events remains to be established.

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Section: Discussionmentioning

confidence: 99%

Effects of exposure to air pollution on blood coagulation

Baccarelli

Zanobetti²,

Martinelli

et al. 2007

Journal of Thrombosis and Haemostasis

197

130

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“…Albumin was determined according to Pinnell and Northam [ 25 ] method. Prothrombin time was determined using standard thromboplastin method [ 26 ]. Blood picture was done on Coulter Counter T890, (Coulter Counter, Harpenden, UK) [ 27 ].…”

Section: Methodsmentioning

confidence: 99%

Serum Levels of Interleukin-6 and Interleukin-10 as Biomarkers for Hepatocellular Carcinoma in Egyptian Patients

Othman

Aref

Mohamed³

et al. 2013

ISRN Hepatology

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Interleukin-10 (IL-10) and interleukin-6 (IL-6) have been reported to be related to hepatocellular carcinoma (HCC) prognosis. This study aimed to investigate the clinical usefulness of serum levels of IL-6 and IL-10 as biomarkers for HCC among high-risk patients. Materials and Methods. 80 individuals were enrolled in this study; they were categorized into 4 groups: group 1 healthy individuals (NC) (n = 20), group 2 chronic hepatitis C virus (HCV) patients (n = 20), group 3 cirrhotic patients (LC) (n = 20), and HCC group (n = 20). Using ELISA technique serum levels of IL-6, IL-10, and alpha fetoprotein (AFP) were evaluated in all groups. Results. The mean serum levels of IL-6 were significantly higher in HCC than in LC, HCV, and NC groups (13.99 ± 1.80, 7.49 ± 0.43, 5.78 ± 0.74, and 2.57 ± 0.31), respectively (P < 0.05); also the serum levels of IL-10 were significantly higher in HCC compared with LC, HCV, and NC groups (13.69 ± 1.89, 7.37 ± 0.53, 5.18 ± 0.6, and 3.31 ± 0.42) (P < 0.05). We also found that the tumor size is correlated strongly with IL-6 and IL-10 levels (r = 0.925, P < 0.001; r = 0.821, P < 0.001), respectively. Conclusion. The combination of those markers may help to identify a group of HCC patients with low AFP.

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“…to note that while no clotting time in the control period was as high as 45 min., 74 of the 79 dogs attained at least this value some time after ir-…”

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confidence: 90%

Progress Report Abnormal Bleeding

Allen¹

1950

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Determination of Prothrombin

Cited by 50 publications

References 0 publications

Effects of exposure to air pollution on blood coagulation

Effects of exposure to air pollution on blood coagulation

Serum Levels of Interleukin-6 and Interleukin-10 as Biomarkers for Hepatocellular Carcinoma in Egyptian Patients

Progress Report Abnormal Bleeding

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