Determination of paracetamol in intact tablets by use of near infrared transmittance spectroscopy

Eustaquio, Alba; Blanco, M.; Jee, Roger D.; Moffat, A.C.

doi:10.1016/s0003-2670(98)00815-0

Cited by 69 publications

(38 citation statements)

References 12 publications

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“…Various methods have been studied for the single determination of DA or PAR, for example, in detecting DA, HPLC [10], as fluorometry [11], UV-vis [12], and, in detecting PAR, spectrophotometry [13][14][15][16][17], near infrared transmittance spectroscopy [18], Fourier transform infrared spectrophotometry [19], spectrofluorometry [20,21], and chromatography [22,23]. However, the majority of these methods suffer from some disadvantages such as high costs, long analysis times, and requirement for sample pretreatment, and in some cases low sensitivity and selectivity that makes them unsuitable for routine analysis.…”

Section: Introductionmentioning

confidence: 99%

Development of a Method for a Sensitive Simultaneous Determination of Dopamine and Paracetamol in Biological Samples and Pharmaceutical Preparations

Babaei

Dehdashti

Afrasiabi

2011

International Journal of Electrochemistry

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A chemically modified electrode is constructed based on multiwalled carbon nanotube-modified glassy carbon electrode (MWCNTs/GCE). The measurements were carried out by application of differential pulse voltammetry (DPV), cyclic voltammetry (CV), and chronoamperometry (CA) methods. Application of DPV method showed wide linear range of DA from 1 μM to 540 μM and a detection limit of 0.098 μM (S/N = 3). The linear range of PAR of 3 μM to 300 μM and a detection limit of 0.15 μM, were obtained. The modified electrode showed electrochemical responses with high sensitivity, high selectivity, and excellent stability for DA and PAR determination at optimal conditions, which makes it a suitable sensor for simultaneous submicromolar detection of DA and PAR in solutions. The analytical performance of this sensor has been evaluated for detection of DA and PAR in human serum, human urine, and pharmaceutical preparation with satisfactory results.

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Section: Introductionmentioning

confidence: 99%

Development of a Method for a Sensitive Simultaneous Determination of Dopamine and Paracetamol in Biological Samples and Pharmaceutical Preparations

Babaei

Dehdashti

Afrasiabi

2011

International Journal of Electrochemistry

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“…Numerous methods have been used for the determination of paracetamol in pharmaceutical formulations and biological fluids including titrimetry [5,6], UV-Vis spectrophotometry [7][8][9][10], spectrofluorimetry [11], near infrared transmittance spectroscopy [12], electrochemical methods [13,14], and chromatography [10,[15][16][17][18][19]. Recently, several flow injection (FI) methods for the determination of paracetamol have been proposed using an UV-Vis spectrophotometer [20][21][22], fluorimeter [23], multioptosensor [24], or Fourier transform infrared spectrophotometer [25] as a detector.…”

Section: Introductionmentioning

confidence: 99%

Rapid and accurate amperometric determination of acetaminophen in pharmaceutical preparations and spiked human blood serum samples at cadmium pentacyanonitrosylferrate modified glassy carbon electrode

Razmi

Harasi

2008

JICS

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The present work describes a rapid and accurate amperometric technique for the determination of acetaminophen (ACT) in pharmaceutical preparations and human blood serum, based on electrocatalytic oxidation of ACT at a glassy carbon electrode modified by cadmium pentacyanonitrosylferrate (CdPCNF) film. The electrocatalytic response of the modified GC electrode was linear over the concentration of 1.64-52.90 μM. The limit of detection was found to be 2.04 μM by amperometric technique. The method was successfully utilized for the determination of ACT in various pharmaceutical preparations and the results have been statistically compared with those obtained by the official method. The interference of some pharmaceutical and biological compounds was investigated. The results of interference study showed that the Nafion-coated CdPCNF|GC electrode can be utilized as a selective amperometric sensor for acetaminophen determination in human blood serum. The mean value of rate constant k for catalytic reaction, and the diffusion coefficient of ACT (D) in the phosphate buffer solution of pH 7.2 were found to be 4.27 10 2 M -1 s -1 , and (4.25 ± 0.33) 10 -6 cm 2 s -1 , respectively.

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“…Accordingly, it was possible to discriminate between the homothetic dosages of Bactrim ® and to separate low dosage Lexotan ® and Valium ® formulations. That is why transmittance analysis may be better suited for quantitative determinations [8], in so far as the sample holders fit the size of samples.…”

Section: Discussionmentioning

confidence: 99%

Non-invasive confirmation of the identity of tablets by near-infrared spectroscopy

Ulmschneider

Pénigault

2000

Analusis

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Abstract. Calibration of non-invasive near-infrared (NIR) analysis for measurements in diffuse reflectance and transmittance was conducted to confirm the identity of different film-coated and uncoated tablets. NIR-spectra of both sides of the intact tablets were recorded in diffuse reflectance. The second derivation of the spectra was computed and spectral matching was calibrated. A restricted wavelength range was proposed to recognize the tablets independently of the presentation over the NIR-light beam. For transmittance measurement, the tablets were arranged in groups according to their similarities. All calibrations were tested against an independent set of sample spectra. The NIR-method proved to be fast and effective.

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Determination of paracetamol in intact tablets by use of near infrared transmittance spectroscopy

Cited by 69 publications

References 12 publications

Development of a Method for a Sensitive Simultaneous Determination of Dopamine and Paracetamol in Biological Samples and Pharmaceutical Preparations

Development of a Method for a Sensitive Simultaneous Determination of Dopamine and Paracetamol in Biological Samples and Pharmaceutical Preparations

Rapid and accurate amperometric determination of acetaminophen in pharmaceutical preparations and spiked human blood serum samples at cadmium pentacyanonitrosylferrate modified glassy carbon electrode

Non-invasive confirmation of the identity of tablets by near-infrared spectroscopy

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