Non-invasive confirmation of the identity of tablets by near-infrared spectroscopy

Abstract

Abstract. Calibration of non-invasive near-infrared (NIR) analysis for measurements in diffuse reflectance and transmittance was conducted to confirm the identity of different film-coated and uncoated tablets. NIR-spectra of both sides of the intact tablets were recorded in diffuse reflectance. The second derivation of the spectra was computed and spectral matching was calibrated. A restricted wavelength range was proposed to recognize the tablets independently of the presentation over the NIR-light beam. For transmittance measurement, the tablets were arranged in groups according to their similarities. All calibrations were tested against an independent set of sample spectra. The NIR-method proved to be fast and effective.

Challenging Near InfraRed Spectroscopy discriminating ability for counterfeit pharmaceuticals detection

“…For example the Regularised, Linear or Quadratic Discriminant Analysis (RDA/LDA/QDA) are methods focusing on finding discriminant functions between classes [24]. The Nircal ® Cluster algorithm consists in a class oriented PCA [25,26]. For each calibration spectrum, a tolerance radius is determined, and the hyperspheres describing the clusters of each class are projected in the PC space.…”

Spectroscopic Characteristics of Xeloda Chemodrug

“…NIR spectroscopy is a common technique for the identification of different tablets. 24 Here, this method was employed to study the structure of chemical bindings in different Xeloda concentrations in deionized water over a wide spectral range of 900-2500 nm. Figure 6a depicts the NIR spectra for different concentrations from 0.01 to 10 mg/mL.…”

Near Infrared Spectroscopy in Drug Discovery and Development Processes

“…A lot of publications describe the application of NIRS for the control of excipients, active pharmaceutical ingredients (APIs) and final products. Ulmschneider and co-workers applied NIRS to identify different types of starch, sugar, cellulose, intermediates and APIs with PCA and cluster calibration [49][50][51][52]. NIRS was used by Ebube and co-workers to differentiate between Avicel products [53].…”