Determination of parabens in urine samples by microextraction using packed sorbent and ultra-performance liquid chromatography coupled to tandem mass spectrometry

Jardim, Valeria Cristina; Melo, Lidervan de Paula; Domingues, Diego Soares; Queiroz, Maria Eugênia Costa

doi:10.1016/j.jchromb.2014.10.026

Cited by 38 publications

(4 citation statements)

References 23 publications

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“…[ 8‐14 ] The reported concentrations of parabens in surface water were mainly through wastewater treatment discharges, river flow conditions or deposition of particles from the atmosphere. [ 15,16 ]…”

Section: Introductionmentioning

confidence: 99%

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Determination of seven parabens in surface water samples by UHPLC‐MS/MS and solid‐phase extraction

Thuy,

Phuong,

Thien

et al. 2022

Vietnam Journal of Chemistry

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Parabens are considered one of the ideal preservatives in numerous consumer products due to their high antimicrobial properties. Nevertheless, parabens have the following potentially detrimental effects on human health such as adverse effects on male reproductive system, or accelerated skin aging process and breast cancer. Here, ultra‐high performance liquid chromatography (UHPLC) coupled with a triple quadrupole mass spectrometry (MS/MS) combined with a solid‐phase extraction procedure was optimized for measuring seven parabens in surface water and proposed as a modified analytical method. The optimized protocol was validated according to the requirements of European standard SANTE/12682/2019. The limits of detection and quantification of the method obtained were 0.04 and 0.82 ng L‐1, respectively. The validated method was applied to analyzing surface water samples collected in Hanoi, Vietnam, indicating not only the presence of seven targeted parabens but also the prevalence of methylparaben in all water samples.

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Section: Introductionmentioning

confidence: 99%

“…The UHPLC‐MS/MS has selectivity and short analysis time, which is perfectly suitable for low concentration analyte. [ 16 ] UHPLC‐MS/MS combined with the solid‐phase extraction (SPE) technique not only enriches the analyte amount but also reduces the influence of sample matrix.…”

Section: Introductionmentioning

confidence: 99%

Determination of seven parabens in surface water samples by UHPLC‐MS/MS and solid‐phase extraction

Thuy,

Phuong,

Thien

et al. 2022

Vietnam Journal of Chemistry

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“…Various analytical techniques such as gas chromatography–mass spectrometry (GC–MS) (Azzouz, Rascón, & Ballesteros, 2016; Hui‐Ting, Ding, & Ding, 2017), ultra‐high‐performance liquid chromatography tandem mass spectrometry (UHPLC–MS/MS) (Cristina Jardim, de Paula Melo, Soares Domingues, & Costa Queiroz, 2015; Dewalque, Pirard, Dubois, & Charlier, 2014; Hongzhi Zhao & Hongzhi Zhao, n.d.) and liquid chromatography tandem mass spectrometry (LC–MS/MS) (Silveira, Rocha, Rodrigues, & Barbosa, 2020) have been applied for the identification and quantification of parabens in biological samples.…”

Section: Introductionmentioning

confidence: 99%

“…To avoid these disadvantages, contemporary and efficient microextraction techniques complying with the principals of green analytic chemistry have been evaluated for the determination of parabens in biological samples (Marcinkowska, Konieczna, Marcinkowski, Namie snik, & Kloskowski, 2019). Microextraction by packed sorbent (MEPS) followed by UHPLC-MS/MS (Cristina Jardim et al, 2015) or LC-MS/MS (Silveira et al, 2020) has been successfully applied to human urine analysis. Additionally, human placenta tissue samples have been pretreated using solid-phase matrix dispersion with UHPLC-MS/MS, achieving a simple analysis procedure (Vela-Soria et al, 2014).…”

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confidence: 99%

An improved fabric‐phase sorptive extraction protocol for the determination of seven parabens in human urine by HPLC–DAD

Rigkos

Alampanos

Kabir

et al. 2020

Biomedical Chromatography

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An improved fabric‐phase sorptive extraction (FPSE) protocol has been developed and validated herein for the simple, fast, sensitive and green determination of seven parabens—methyl paraben, ethyl paraben, propyl paraben, butyl paraben, isopropyl paraben, isobutyl paraben and benzyl paraben—in human urine samples by HPLC–DAD. The mobile phase consisted of ammonium acetate (0.05 m) and acetonitrile, while total analysis time was 13.2 min. Sol–gel poly (tetrahydrofuran) coated FPSE membrane resulted in optimum extraction sensitivity for the seven parabens. The novel FPSE medium as well as the improved and faster sample preparation procedure resulted in lower limit of detection and quantitation values in comparison with previously reported methods. The separation was carried out using an RP‐HPLC method with a Spherisorb C18 column and a flow rate of 1.4 ml/min. The validation of the analytical method was carried out by means of linearity, precision, accuracy, selectivity, sensitivity and robustness. For all seven parabens, the limits of detection and quantitation were 0.003 and 0.01 μg/ml, respectively. Relative recovery rates were between 86.3 and 104%, while RSD values were <12.6 and 19.3% for within‐ and between‐day repeatability, respectively. The method was subsequently applied to real human urine samples.

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Application of dispersive liquid-liquid microextraction for the preconcentration of eight parabens in real samples and their determination by high-performance liquid chromatography

et al. 2017

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A simple and sensitive method for the simultaneous determination of eight parabens in human plasma and urine samples was developed. The samples were preconcentrated using dispersive liquid-liquid microextraction based on the solidification of floating organic drops and determined by high-performance liquid chromatography with ultraviolet detection. The influence of variables affecting the extraction efficiency was investigated and optimized using Placket-Burman design and Box-Behnken design. The optimized values were: 58 μL of 1-decanol (as extraction solvent), 0.65 mL methanol (as disperser solvent), 1.5% w/v NaCl in 5.0 mL of sample solution, pH 10.6, and 4.0 min centrifugation at 4000 rpm. The extract was injected into the high-performance liquid chromatography system for analysis. Under the optimum conditions, the linear ranges for eight parabens in plasma and urine were 1.0-1000 ng/mL, with correlation coefficients above 0.994. The limit of detection was 0.2-0.4 and 0.1-0.4 ng/mL for plasma and urine samples, respectively. Relative recoveries were between 80.3 and 110.7%, while relative standard deviations were less than 5.4%. Finally, the method was applied to analyze the parabens in 98 patients of primary breast cancer. Results showed that parabens existed widely, at least one paraben detected in 96.9% (95/98) of plasma samples and 98.0% (96/98) of urine samples.

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Determination of parabens in urine samples by microextraction using packed sorbent and ultra-performance liquid chromatography coupled to tandem mass spectrometry

Cited by 38 publications

References 23 publications

Determination of seven parabens in surface water samples by UHPLC‐MS/MS and solid‐phase extraction

Determination of seven parabens in surface water samples by UHPLC‐MS/MS and solid‐phase extraction

An improved fabric‐phase sorptive extraction protocol for the determination of seven parabens in human urine by HPLC–DAD

Application of dispersive liquid-liquid microextraction for the preconcentration of eight parabens in real samples and their determination by high-performance liquid chromatography

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