Determination of naproxen in pharmaceuticals by differential pulse voltammetry at a platinum electrode

Adhoum, Nafaâ; Monser, Lotfi; Toumi, Meriem; Boujlel, Khaled

doi:10.1016/s0003-2670(03)00922-x

Cited by 79 publications

(51 citation statements)

References 13 publications

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“…The analytical frequency estimated in this amperometric recording is higher than 90 h -1 (much superior than the DPV methods previously reported). 12,13 A linear behavior, with a good correlation coefficient (R > 0.99), was observed from 10 to 100 µmol L -1 naproxen with similar slope values for both curves (0.357 and 0.336 µA L µmol -1 ). Electrode fouling was not verified between injections of standard solutions, as evidenced by the fact that current responses were not diminished during amperometric measurements due to the application of a cleaning potential pulse (+1.0 V) using the pulsed amperometric detection technique.…”

mentioning

confidence: 68%

“…However, both electroanalytical procedures employed non-aqueous electrolyte. 12,13 Figure 4 presents amperometric responses for triplicate injections of solutions containing increasing concentrations of naproxen (a-e: 10-100 µmol L -1 ). The respective calibration curves (increasing and decreasing order) are also presented (inset).…”

Section: Resultsmentioning

confidence: 99%

“…13 To our knowledge, there are no amperometric methods reported to the determination of naproxen and the electroanalytical methods developed for naproxen determination required non-aqueous electrolyte. 12,13 The association of flow injection analysis (FIA) with electrochemical detectors for the development of analytical methods provides high-speed, sensitivity, selectivity, accuracy and precision. 15,16 Batch injection analysis (BIA) presents similar characteristics and can be an interesting alternative to FIA in such a way that pumps and valves of the FIA system are not necessary and reduced volumes of carrier solutions are employed.…”

Section: Introductionmentioning

confidence: 99%

“…Analytical methods employing differential pulse voltammetry (DPV) at a platinum electrode 12 and at a boron-doped diamond (BDD) electrode 13 were reported for the determination of naproxen in non-aqueous electrolyte (acetonitrile supported with 0.1 mol L -1 LiClO 4 ). BDD electrodes provide lower low background current and wide potential window 14 and due to these characteristics, the determination of naproxen at the BDD electrode presented superior sensitivity.…”

Section: Introductionmentioning

confidence: 99%

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Fast determination of naproxen in pharmaceutical formulations by batch injection analysis with pulsed amperometric detection

Stefano¹,

Lima²,

Montes³

et al. 2012

J. Braz. Chem. Soc.

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Um método eletroanalítico original e rápido para a determinação de naproxeno em formulações farmacêuticas usando análise por injeção em batelada (BIA) com detecção amperométrica pulsada é descrito. Eletrodo de carbono vítreo foi usado como eletrodo de trabalho e solução tampão fosfato 0,05 mol L -1 como eletrólito suporte. O método amperométrico envolveu a aplicação contínua de dois pulsos de potencial ao eletrodo de trabalho com intuito de detectar naproxeno pela sua oxidação eletroquímica (+1,5 V por 200 ms) e de limpar a superfície do eletrodo de produtos de adsorção (+1,0 V por 100 ms), evitando contaminação do eletrodo. O método proposto possui várias vantagens para análises de rotina, incluindo: baixo desvio padrão relativo (3,0%, n = 10), elevada frequência analítica (90 h -1 ), exatidão satisfatória (baseado em determinações comparativas por espectrofluorimetria) e baixo limite de detecção (0,3 µmol L -1 ).A novel and fast electroanalytical method for naproxen determination in pharmaceutical formulations using batch injection analysis (BIA) with pulsed amperometric detection is described. Bare glassy carbon electrode was used as working electrode and 0.05 mol L -1 phosphate buffer solution as supporting electrolyte. The amperometric method involved the continuous application of two sequential potential pulses to the working electrode in order to detect naproxen by its electrochemical oxidation (+1.5 V for 200 ms) and to clean the electrode surface from adsorption products (+1.0 V for 100 ms), avoiding electrode contamination. The proposed method has several advantages for routine analysis, including: a low relative standard deviation between injections (3.0%, n = 10), high analytical frequency (90 h -1 ), satisfactory accuracy (based on comparative determinations by spectrofluorimetry) and low limit of detection (0.3 µmol L -1 ).Keywords: batch injection analysis, multiple-pulse amperometry, non-steroidal antiinflammatory drug IntroductionNaproxen, 2-(6-methoxynaphthalen-2-yl) propanoic acid, is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and has been widely used as an over-the-counter analgesic, anti-inflammatory and antipyretic agent. It is also commonly used for the reduction of stiffness caused by conditions including kidney stones, rheumatoid arthritis and other inflammatory rheumatic diseases. 1,2 NSAIDs have been associated with the increasing number of potentially cardiovascular events. However, a recent study classified naproxen as the least harmful NSAID in cardiovascular terms. 3 Different analytical methods have been proposed for the determination of naproxen in pharmaceutical formulations including spectrophotometry (UV region), 4,5 spectrofluorimetry, 6-8 capillary isotachophoresis 9 and high-performance liquid-chromatography (HPLC) coupled with spectrophotometric, 10 amperometric 11 and mass spectrometric detectors. 1 Nevertheless, these analytical methods require expensive equipment and reagents, are time-consuming and often necessitate laborious pre-and pos...

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mentioning

confidence: 68%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Fast determination of naproxen in pharmaceutical formulations by batch injection analysis with pulsed amperometric detection

Stefano¹,

Lima²,

Montes³

et al. 2012

J. Braz. Chem. Soc.

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“…Several analytical methods have been reported for the determination of naproxen in pharmaceutical preparations including UV-visible spectrophotomery, [3][4][5] spectrofluorimetry, [6][7][8] room temperature phosphorimetry, 9,10 voltametry, 11 high-performance liquid chromatography, [12][13][14] capillary electrophoresis, 15,16 coulometry 17 and oscilometric titration. 18 However, most of these techniques are timeconsuming, involving the use of organic solvents or require expensive and sophisticated instruments and for this reason they are not suitable for routine analysis.…”

Section: Introductionmentioning

confidence: 99%

A novel potentiometric naproxenate ion sensor immobilized in a graphite matrix for determination of naproxen in pharmaceuticals

Santini¹,

Oliveira²,

Pezza³

et al. 2006

J. Braz. Chem. Soc.

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As características, o desempenho e a aplicação de um eletrodo do tipo Pt⎪Hg⎪Hg 2 (NAP) 2 ⎪ Graphite, onde NAP=íon naproxenato, são descritas. O eletrodo responde a NAP com sensibilidade de (58,1± 0,9) mV década -1 no intervalo de 5,0 × 10 -5 -1,0 × 10 -2 mol L -1 , a pH 6,0-9,0 e com um limite de detecção de 3,9 × 10 -5 mol L -1 . O eletrodo é de baixo custo e facilmente construído, apresenta um rápido tempo de resposta (10-35 s) e pode ser usado por um período de seis meses sem qualquer divergência considerável nos potenciais. O sensor supracitado mostrou boa seletividade para naproxeno na presença de várias substâncias, tais como carboxilatos e ânions inorgânicos, sendo aplicado na análise direta de naproxeno em medicamentos (comprimidos) via método da adição de padrão. Os resultados analíticos obtidos com o eletrodo proposto estão em boa concordância com aqueles obtidos pelo procedimento preconizado na Farmacopéia Americana.The characteristics, performance, and application of an electrode, namely, Pt⎪Hg⎪Hg 2 (NAP) 2 ⎪ Graphite, where NAP stands for naproxenate ion, are described. This electrode responds to NAP with sensivity of (58.1± 0.9) mV decade -1 over the range 5.0 × 10 -5 -1.0 × 10 -2 mol L -1 at pH 6.0-9.0 and a detection limit of 3.9 × 10 -5 mol L -1 . The electrode is easily constructed at a relatively low cost with fast response time (within 10-35 s) and can be used for a period of 6 months without any considerable divergence in potentials. The proposed sensor displayed good selectivity for naproxen in the presence of several substances, especially concerning carboxylate and inorganic anions. It was used for the direct assay of naproxen in commercial tablets by means of the standard additions method. The analytical results obtained by using this electrode are in good agreement with those given by the United States Pharmacopeia procedure.Keywords: naproxenate-sensitive electrode, potentiometry, pharmaceutical formulations Introduction Naproxen [(+)-2-(6-metoxy-2naphthyl)propionic acid], is a non-steroidal anti-inflammatory drug that also presents analgesic and antipyretic properties often preferred to acetylsalicylic acid because of its better absortion following oral administration and fewer adverse effects.Naproxen is extensively used in the treatment of many diseases like rheumatoid arthrits, degenerative joint disease, ankylosing spondylits, acute gout and primary dismenorrea. 1 Like other non-steroidal anti-inflammatory drugs, it inhibits the biosyntesis of prostaglandins. 1 The United States Pharmacopeia 2 2003 reports an highperformance liquid chromatography (HPLC) method for the determination of naproxen tablets. Several analytical methods have been reported for the determination of naproxen in pharmaceutical preparations including UV-visible spectrophotomery, 3-5 spectrofluorimetry, 6-8 room temperature phosphorimetry, 9,10 voltametry, 11 high-performance liquid chromatography, 12-14 capillary electrophoresis, 15,16 coulometry 17 and oscilometric titration. 18 However, most of these techniq...

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Chemiluminescence determination of naproxen based on europium(III)‐sensitized KIO₄–H₂O₂ reaction

Du¹,

Li²,

Lu³

2009

Luminescence

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A simple and sensitive chemiluminescence (CL) method combined with flow injection technique was developed for the determination of naproxen. It was based upon the weak CL signal arising from the reaction of KIO(4) with H(2)O(2) being significantly increased by naproxen in the presence of europium(III) ion. The experimental conditions that affected the CL signal were carefully optimized and the CL reaction mechanism was briefly discussed. Under the optimum conditions, the increment of CL intensity was proportional to the concentration of naproxen ranging from 5.0 x 10(-8) to 5.0 x 10(-6) g/mL. The detection limit was 1 x 10(-8) g/mL naproxen and the relative standard deviation for 5.0 x 10(-7) g/mL naproxen solution was 2.1% (n = 11). The proposed method was applied to the determination of naproxen in tablets and in spiked human urine samples with satisfactory results.

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Determination of naproxen in pharmaceuticals by differential pulse voltammetry at a platinum electrode

Cited by 79 publications

References 13 publications

Fast determination of naproxen in pharmaceutical formulations by batch injection analysis with pulsed amperometric detection

Fast determination of naproxen in pharmaceutical formulations by batch injection analysis with pulsed amperometric detection

A novel potentiometric naproxenate ion sensor immobilized in a graphite matrix for determination of naproxen in pharmaceuticals

Chemiluminescence determination of naproxen based on europium(III)‐sensitized KIO₄–H₂O₂ reaction

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Determination of naproxen in pharmaceuticals by differential pulse voltammetry at a platinum electrode

Cited by 79 publications

References 13 publications

Fast determination of naproxen in pharmaceutical formulations by batch injection analysis with pulsed amperometric detection

Fast determination of naproxen in pharmaceutical formulations by batch injection analysis with pulsed amperometric detection

A novel potentiometric naproxenate ion sensor immobilized in a graphite matrix for determination of naproxen in pharmaceuticals

Chemiluminescence determination of naproxen based on europium(III)‐sensitized KIO4–H2O2 reaction

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Chemiluminescence determination of naproxen based on europium(III)‐sensitized KIO₄–H₂O₂ reaction