Determination of myo-inositol in infant formulae and milk powders using capillary gas chromatography with flame ionisation detection

Woollard, David C; Macfadzean, C; Indyk, Harvey E.; McMahon, Adrienne; Christiansen, Scott

doi:10.1016/j.idairyj.2014.03.004

Cited by 16 publications

(7 citation statements)

References 29 publications

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“…The galactose content was higher than those found by Morales et al (2004) and similar to those obtained by Troyano, Villamiel, Olano, Sanz, and Martinez-Castro (1996) in commercial sterilized milks. Myo-inositol, a polyalcohol that may play a significant role in the prevention of bronchopulmonary dysplasia and retinopathy in premature infants (Hallman, Saugstad, Porreco, Epstein, & Gluck, 1985), was present in all IFs at concentrations significantly higher than those reported for Spanish commercial milks (Troyano et al, 1996), but similar to the found by Woollard, Macfadzean, Indyk, McMahon, and Christiansen (2014). As expected, with the exception of the lactose-free IFs, lactose was the main carbohydrate in all studied products, with amounts varying between 19.2 and 70.1 g/100 g. Maltose was found in most of the analysed IFs in a range from 0.2 to 7 g/100 g. This compound is usually not added as ingredient in IFs and its presence may be related to the partial hydrolysis of the added maltodextrins during processing.…”

Section: Resultssupporting

confidence: 67%

Quantification of prebiotics in commercial infant formulas

Sabater¹,

Pródanov²,

Olano³

et al. 2016

Food Chemistry

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Since breastfeeding is not always possible, infant formulas (IFs) are supplemented with prebiotic oligosaccharides, such as galactooligosaccharides (GOS) and/or fructooligosaccharides (FOS) to exert similar effects to those of the breast milk. Nowadays, a great number of infant formulas enriched with prebiotics are disposal in the market, however there are scarce data about their composition. In this study, the combined use of two chromatographic methods (GC-FID and HPLC-RID) for the quantification of carbohydrates present in commercial infant formulas have been used. According to the results obtained by GC-FID for products containing prebiotics, the content of FOS, GOS and GOS/FOS was in the ranges of 1.6-5.0, 1.7-3.2, and 0.08-0.25/2.3-3.8g/100g of product, respectively. HPLC-RID analysis allowed quantification of maltodextrins with degree of polymerization (DP) up to 19. The methodology proposed here may be used for routine quality control of infant formula and other food ingredients containing prebiotics.

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Section: Resultssupporting

confidence: 67%

Quantification of prebiotics in commercial infant formulas

Sabater¹,

Pródanov²,

Olano³

et al. 2016

Food Chemistry

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“…Free inositols occur naturally in the environment as a bioactive component of living cells. Milk is a significant source of myo-inositol and for its role in neonatal nutrition, this polyol is often added to infant formulas to prevent a potential deficiency during early neonatal growth stage [38]. As well as urea, myo-inositol is osmolyte and the lower level of this polyol in GS2 can counterbalance their high urea content.…”

Section: Discussionmentioning

confidence: 99%

An Untargeted Metabolomic Comparison of Milk Composition from Sheep Kept Under Different Grazing Systems

Scano

Carta²,

Ibba³

et al. 2020

Dairy

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This study aimed to evaluate the effects of different feedings on main traits and polar and semi-polar metabolite profiles of ovine milk. The milk metabolome of two groups of Sarda sheep kept under different grazing systems were analyzed by gas chromatography coupled with mass spectrometry (GC-MS) and multivariate statistical analysis (MVA). The results of discriminant analysis indicated that the two groups showed a different metabolite profile, i.e., milk samples of sheep kept under Grazing System 1 (GS1) were richer in nucleosides, inositols, hippuric acid, and organic acids, while milk of sheep under Grazing System 2 (GS2) showed higher levels of phosphate. Statistical analysis of milk main traits indicates that fat content was significantly higher in GS1 samples while milk from GS2 sheep had more urea, trans-vaccenic acid, and rumenic acid. MVA studies of the associations between milk main traits and metabolite profile indicated that the latter reflects primarily the long chain fatty acid content, the somatic cell count (SCC), and lactose levels. All together, these results demonstrated that an integrated holistic approach could be applied to deepen knowledge about the effects of feeding on sheep’s milk composition.

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“…Myo-inositol, as a conditionally essential nutrient, has been shown to have chemopreventive and chemotherapeutic properties in cancer, cataracts, neuropathy, and nephropathy (Grases et al, 2002;Rizvi et al, 2006;Liu et al, 2009;Schlemmer et al, 2009;Corrado et al, 2011). Additionally, myo-inositol is a compound necessary for babies, and when this substance cannot be administered through breast milk, it must be sup- plied in the diet by inositol-enriched milk or formula (Hallman et al, 1987;Flores et al, 2011;Woollard et al, 2014;Indyk et al, 2016). In this study, myo-inositol was also identified in donkey milk.…”

Section: Discussionmentioning

confidence: 62%

Comparative metabolomics analysis of donkey colostrum and mature milk using ultra-high-performance liquid tandem chromatography quadrupole time-of-flight mass spectrometry

Liang

Kang

Zheng

et al. 2020

Journal of Dairy Science

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Donkey milk has been widely shown to be an ideal substitute for human milk because of its similar composition. However, alterations to the composition of donkey milk during lactation have not been well studied. In this study, untargeted metabolomics with ultra-high-performance liquid tandem chromatography quadrupole time-of-flight mass spectrometry were used to analyze and compare the metabolites in donkey colostrum (DC) and mature milk (DMM). Two hundred seventy metabolites were characterized in both DC and DMM. Fifty-two of the metabolites in the DC were significantly different from those in the DMM; 8 were downregulated and 44 were upregulated. This demonstrated that the composition of the donkey milk changed with lactation. Additionally, the interactions and metabolic pathways were further analyzed to explore the mechanisms that altered the milk during lactation. Our results provide comprehensive insights into the alterations in donkey milk during lactation. The results will aid in future investigations into the nutrition of donkey milk and provide practical information for the dairy industry.

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Determination of myo-inositol in infant formulae and milk powders using capillary gas chromatography with flame ionisation detection

Cited by 16 publications

References 29 publications

Quantification of prebiotics in commercial infant formulas

Quantification of prebiotics in commercial infant formulas

An Untargeted Metabolomic Comparison of Milk Composition from Sheep Kept Under Different Grazing Systems

Comparative metabolomics analysis of donkey colostrum and mature milk using ultra-high-performance liquid tandem chromatography quadrupole time-of-flight mass spectrometry

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