Determination of metoprolol enantiomers in human urine by coupled achiral–chiral chromatography

Stereoselective analysis of metoprolol and its metabolites in rat plasma with application to oxidative metabolism

“…Both methods have been applied to the separation of metoprolol isomers [1,[12][13][14]. Recently, chiral chromatography methods have been developed for metoprolol enantiomers in plasma and urine [15,16].…”

Recent developments of enantioseparation techniques for adrenergic drugs using liquid chromatography and capillary electrophoresis: A review

“…Many adrenergic blocker enantiomers such as atenolol, alprenolol, acebutolol, metoprolol, bisoprolol and tolamolol were separated using the Chiralcel OD column [48,49]. The interactions are assumed to be the hydrogen bonding and -interaction between CSP and drugs.…”

Role of biological matrices during the analysis of chiral drugs by liquid chromatography

“…The on-line achiral-chiral systems were developed for the determinations of metoprolol in human urine [130]; verapamil and its metabolites in serum [104]; tramadol enantiomers in human urine [105]; verapamil in human plasma [131]; eliprodil in human plasma and urine [132]. Two different types of CSW set-up (single-pump system with ovomucoid CSP as well as two-pumps set-up with teicoplanin CSP) were compared for determination of propranolol enantiomers in rat blood microdialysate [59].…”