Determination of losartan, telmisartan, and valsartan by direct injection of human urine into a column-switching liquid chromatographic system with fluorescence detection

Brunetto, Marı́a del Rosario; Contreras, Yaritza; Clavijo, Sabrina; Torres, Dina; Delgado, Yelitza; Ovalles, Fernando; Ayala, Carlos; Gallignani, Máximo; Estela, José Manuel; Martin, Víctor Cerdà

doi:10.1016/j.jpba.2009.04.015

Cited by 65 publications

(29 citation statements)

References 40 publications

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“…While analysts were extracted from the matrix using an on-line solid-phase extraction using solution 2% methanol in 5mM phosphate buffer (pH 3.8) at a flow-rate of 0.8 mL/min [16].…”

Section: R Brunetto Et Al (2009) Studiedmentioning

confidence: 99%

A Concise Review on Analytical Profile of Valsartan

Shirkhedkar¹,

Chaudhari²,

Patil³

et al. 2017

Eurasian J Anal Chem

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Valsartan (VAL) is an orally active angiotensin-II receptor type-I antagonist. VAL is available alone in dosage form as well as multicomponent formulation with various antihypertensive drugs like nifedipine, hydrochlorothiazide, ramipril, amlodipine and nebivolol hydrochloride, for the management of hypertension. The present investigation assesses the various approaches for analysis of VAL in bulk drug as well as formulated products. A concise review represents the compilation and discussion of about more than 90 analytical methods which includes HPLC, HPTLC, capillary electrophoresis, electrochemical methods and UV-Spectrophotometry methods implemented for investigation of VAL in biological matrices, bulk samples and in different dosage formulations. The review describes the percentage utilization of the various approaches for analysis of VAL. The statistical data regarding the utility of these methods for estimation of VAL published during 2001 to 2016 have been included.

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“…While analysts were extracted from the matrix using an on-line solid-phase extraction using solution 2% methanol in 5mM phosphate buffer (pH 3.8) at a flow-rate of 0.8 mL/min [16].…”

Section: R Brunetto Et Al (2009) Studiedmentioning

confidence: 99%

A Concise Review on Analytical Profile of Valsartan

Shirkhedkar¹,

Chaudhari²,

Patil³

et al. 2017

Eurasian J Anal Chem

View full text Add to dashboard Cite

show abstract

“…The percent recovery was evaluated, by comparing the peak area of extracted analytes to the peak area of non extracted standards [38,39].…”

Section: Validationmentioning

confidence: 99%

Development and Validation of a High Performance Liquid Chromatography Method for Determination of Telmisartan in Rabbit Plasma and its Application to a Pharmacokinetic Study

Virkar¹,

Pingale²

2012

J Anal Bioanal Techniques

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A simple and sensitive High-Performance Liquid Chromatography (HPLC) method with fluorescence detection for quantitation of telmisartan in rabbit plasma was developed and validated. Separation of telmisartan from plasma components was achieved on a Chromolith RP18e column (100 x 4.6 mm 5 µ). Losartan was used as an internal standard. A mobile phase consisting of 50 mM sodium phosphate buffer and acetonitrile in the volume ratio of 65:35 v/v was delivered at a flow rate of 3.5 mL/min.A simple and rapid sample preparation involved solid phase extraction using Varian Bond Elute C-18 cartridge. The linearity range of the proposed method was 4 to 375 ng/mL. The intra-day and inter-day coefficients of variation obtained for telmisartan were less than 4.90% and relative error was less than 9.08%. The overall recoveries for telmisartan and losartan were 101.7% and 100.0%, respectively. This validated method was used successfully for analysis of plasma samples from a pharmacokinetic study.

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“…(100 Â 4.6 mm) [28] Mycophenolic acid, mycophenolic acid glucuronide [24][25][26] Cyclosporin A [27] Busulfan [28] Sirolimus [29] Blood pressure drugs HPLC-fluorescence [30][31][32]34], HPLC-UV [33], HPLC-MS/MS [35] Plasma [30][31][32][33]35], urine [30,34] Chromolith Performance RP-18e (100…”

Section: Hplc-ms/ms [21]mentioning

confidence: 99%

Applications of monolithic columns in liquid chromatography‐based clinical chemistry assays

Bunch

Wang

2011

J of Separation Science

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Monolithic columns have slowly been applied to HPLC methods for clinical chemistry testing in the last 10 years. The application areas include therapeutic drug monitoring, drugs of abuse, vitamins, porphyrins, and steroids. In comparison with conventional particulate columns, the monolithic columns may offer shorter chromatography time, more robustness, and better resolution for certain analytes. The potential drawback of large mobile phase consumption may be improved with smaller id columns, which are currently on the market. Methods covered in this review are those searchable in PubMed up to December 2010. This review highlights the emergence of monolithic column technology in HPLC methods used for clinical chemistry testing. The goals of this review are threefold: (i) To identify the areas of clinical chemistry that analytical monolithic columns have been used in HPLC methods. (ii) To demonstrate the application of analytical monolithic columns in HPLC methods using different detection systems. (iii) To discuss the advantages and limitations of the monolithic columns compared with particulate columns in the clinical chemistry applications.

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Determination of losartan, telmisartan, and valsartan by direct injection of human urine into a column-switching liquid chromatographic system with fluorescence detection

Cited by 65 publications

References 40 publications

A Concise Review on Analytical Profile of Valsartan

A Concise Review on Analytical Profile of Valsartan

Development and Validation of a High Performance Liquid Chromatography Method for Determination of Telmisartan in Rabbit Plasma and its Application to a Pharmacokinetic Study

Applications of monolithic columns in liquid chromatography‐based clinical chemistry assays

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