A Concise Review on Analytical Profile of Valsartan

Abstract

Valsartan (VAL) is an orally active angiotensin-II receptor type-I antagonist. VAL is available alone in dosage form as well as multicomponent formulation with various antihypertensive drugs like nifedipine, hydrochlorothiazide, ramipril, amlodipine and nebivolol hydrochloride, for the management of hypertension. The present investigation assesses the various approaches for analysis of VAL in bulk drug as well as formulated products. A concise review represents the compilation and discussion of about more than 90 analytical methods which includes HPLC, HPTLC, capillary electrophoresis, electrochemical methods and UV-Spectrophotometry methods implemented for investigation of VAL in biological matrices, bulk samples and in different dosage formulations. The review describes the percentage utilization of the various approaches for analysis of VAL. The statistical data regarding the utility of these methods for estimation of VAL published during 2001 to 2016 have been included.

Validated HPLC and stability-indicating densitometric chromatographic methods for simultaneous determination of camylofin dihydrochloride and paracetamol in their binary mixture

“…Paracetamol (N-acetyl-para-amino-phenol) has antipyretic and analgesic action and weak anti-inflammatory effect [1]. Many techniques have been used for its determination, including spectrophotometry [15][16][17], HPLC [18][19][20][21] TLC [22][23][24][25], GC [26][27][28][29], fluorometry [30][31][32] and electrochemistry [33][34][35][36].…”

A New and Cost Effective Approach for Simultaneous Voltammetric Analysis of two Related Benzimidazole Drugs and their Determination in Biological Fluids

“…Sometimes, they are administered separately and commonly administered in a binary mixture form in capsules. Analytical literatures concerning the determination of such mixture include UV‐spectrophotometric methods , spectrodensitometry , HPLC method .…”