Determination of lisinopril in dosage forms and spiked human plasma through derivatization with 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole (NBD-Cl) followed by spectrophotometry or HPLC with fluorimetric detection

An HPLC method for the determination of lisinopril in human plasma and urine with fluorescence detection

“…As mentioned in the Introduction part, sensitivity of the HPLC method with UV detection [17] or fluorescence detection [18] is too low to determine the low drug plasma concentrations. Other methods developed for pharmacokinetic studies such as radio-, fluoro-immunoassay and GC-MS techniques [14][15][16] are very sensitive with 0.2-0.7 ng/ml LOQ values but not readily applicable for many researchers since they generally require expensive devices or reagents.…”

Novel liquid chromatographic methods for the determination of varenicline tartrate

“…NBD-Cl has been used as a useful derivatizing reagent for primary amines, secondary amines, thiols, etc. [28][29][30][31][32][33]. So the development of a fluorimetric stabilityindicating method was achieved, through precolumn derivatization of VRC with NBDCl, producing a yellow fluorescent complex (Fig.…”

Analytical Determination of Lisinopril Using UV Spectrophotometer and HPLC: An Overview

“…Several High pressure liquid chromatography HPLC methods have been used for the analysis of lisinopril in human plasma [8][9][10]. Sagirli et al [11] developed HPLC method for analysis of lisinopril in human plasma and urine at 477 nm.…”