An HPLC method for the determination of lisinopril in human plasma and urine with fluorescence detection

Rapid quantification of lisinopril in human plasma by liquid chromatography/tandem mass spectrometry

“…The HPLC-UV (Wong and Charles, 1995) method is unsuitable for the measurement of lisinopril in plasma where the drug concentrations are rather low. The HPLC-F (Sagirli and Ersoy, 2004;El-Amam et al, 2004) and GC-MS (Leis et al, 1998(Leis et al, , 1999 methods require derivatization of lisinopril to produce a chromophore detectable by fluorescence or to covert the thermo labile and ionic lisinopril into a derivative that is suitable for gas chromatography analysis. Although the HPLC-MS (Tsakalof et al, 2003) was successfully applied to the determination of lisinopril in human plasma, the lower limit of quantification (LLOQ) in plasma of the method was 6 ng/mL, which was insufficiently sensitive to enable full pharmacokinetic profiling of lisinopril in low dosages.…”

Analytical Determination of Lisinopril Using UV Spectrophotometer and HPLC: An Overview

“…Several High pressure liquid chromatography HPLC methods have been used for the analysis of lisinopril in human plasma [8][9][10]. Sagirli et al [11] developed HPLC method for analysis of lisinopril in human plasma and urine at 477 nm. Linear quantitative response was generated over a concentration range of 5-200 ngmL -1 and 25-1000 ngmL -1 for plasma and urine samples.…”

Chemometric resolution of coeluting peaks of eleven antihypertensives from multiple classes in high performance liquid chromatography: A comprehensive research in human serum, health product and Chinese patent medicine samples

“…The treatment of serum can be summarized as follows: firstly, 2 mL human serum was transferred into a 10 mL centrifugal tube, and then 6 mL of methanol was added and the mixture was sonicated for 30 min [14]. Secondly, the tube was centrifuged for 15 min at 6000 rpm, the supernatant was transferred into another tube.…”

“…In principle, the joint of complementary medicines can not only help to meet the target blood pressure, but also decrease the morbidity and mortality of complications. In practice, many doctors as well as the World Health Organization have been beginning to detector (UV) [10][11][12][13], fluorescence detector (FD) [14,15], amperometric detector (AD) [16], diode array detector (DAD) [17][18][19] and mass spectrometry (MS) [20][21][22]. However, most works have been focused on quantifying a small amount or one kind of antihypertensives in biological matrix or Chinese herbal matrix.…”