Determination of ibuprofen in erythrocytes and plasma by high performance liquid chromatography

Sochor, J; Klimeš, Jiřı́; Sedláček, Jan; Zahradnícek, M

doi:10.1016/0731-7085(95)01306-6

Cited by 32 publications

(17 citation statements)

References 24 publications

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“…[21]. Many of these methods, however, involve several manipulation, extraction and derivatization steps [6,[18][19][20][21], suffer from lack of sensitivity [3,4,20], and require sophisticated instrumentation [5][6][7][11][12][13][14][15][16]. The advantages offered by capillary electrophoresis and HPLC techniques are the detection of enantiomers and metabolites of the drugs.…”

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confidence: 99%

Direct potentiometry and potentiotitrimetry of warfarin and ibuprofen in pharmaceutical preparations using PVC ferroin-based membrane sensors

1998

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Abstract. Sensitive and fast-responding potentiometric sensors are described for the determination of warfarin and ibuprofen. They consist of PVC matrix membranes containing the drug-ferroin ion-association complexes as electroactive materials and dioctylphthalate as a solvent mediator. Linear dynamic response range between 1 x 10 -2 and 2 x 10-SM with Nernstian slopes of 59-60mV/decade concentration and a detection limit of 0.8-1.3 gg/ml are obtained. A wide range of organic anions and drug excipients do not interfere. Titration of the drugs with a standard ferroin solution using either a drug-ferroin or ferroin-TPB PVC sensor in conjunction with an Ag-AgC1 reference electrode displays S-shaped titration curves with sharp potential breaks at stoichiometric 1:2 (ferroin:drug) reaction. Differential titration curves with well-defined peaks at the equivalence points are obtained using drug-ferroirdferroin-TPB PVC membrane sensors. Direct potentiometry and potentiotitrimetry of warfarin and ibuprofen in various pharmaceutical preparations are presented and compared. Several advantages over the pharmacopoeial methods and other techniques in current use are offered by the proposed technique. [21]. Many of these methods, however, involve several manipulation, extraction and derivatization steps [6,[18][19][20][21], suffer from lack of sensitivity [3,4,20], and require sophisticated instrumentation [5][6][7][11][12][13][14][15][16]. The advantages offered by capillary electrophoresis and HPLC techniques are the detection of enantiomers and metabolites of the drugs. The recent amendment of U. S. P described an HPLC method for the assay of warfarin and ibuprofen [22].Although potentiometric sensors have found many applications in pharmaceutical analysis [23][24][25], no such sensors are available for quantification of warfarin and ibuprofen in drug formulations. The only biosensor available for determining warfarin was based on immobilization of a thick suspension of Nocardia corallina as a biocatalyst on a treated vitreous carbon rod and the corresponding alcohol

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confidence: 99%

Direct potentiometry and potentiotitrimetry of warfarin and ibuprofen in pharmaceutical preparations using PVC ferroin-based membrane sensors

1998

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“…Determination of ibuprofen in pharmaceutical and biological fluids has been reported using HPLC (Sochor et al, 1995;Sochor et al, 1994;Castillo and Smith, 1993;Bhushan et al, 2005) and gas-liquid chromatography (Vangiessan and Kaiser, 1975;Kaiser and Martin, 1978). Enantiomeric resolution of ibuprofen in pharmaceutical preparations has been reported (Bhushan and Gupta, 2004;Bhushan and Thiongo, 1999;Bhushan and Parshad, 1996).…”

Section: Introductionmentioning

confidence: 98%

Liquid chromatographic analysis of certain commercial formulations for non‐opioid analgesics

Bhushan

Gupta

Mukherjee

2007

Biomedical Chromatography

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A simple and sensitive method for separation and quantitative determination of non-opioid analgesics from pharmaceutical preparations has been developed and validated. Commercial formulations of three non-opioid analgesics, viz. paracetamol, ibuprofen and diclofenac, were chosen for present studies. These were extracted, isolated, purified and recrystallized and were characterized by melting point, lambda(max) and IR. Quantitative determination was carried out using HPLC and TLC supplemented with UV spectrophotometry.

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“…The working range offered by the presented electrode (22.83-22829 mg mL -1 ) is compared with spectrophotometry (5-3200 mg mL -1 ) [15][16][17] and potentiometric titration (1-10 mg mL -1 ) [24]. The accuracy and precision of the potentiometric method (the mean recovery 99.5-105.2%) is much better than the HPLC method (78-95%) [22] and it is comparable with the accuracy of other methods (capillary electrophoresis 97.65-104.66% [25] spectrofluorimetry 97.9-105% [18,19]). Another advantage of the potentiometric method is short time of a single determination (~30 s).…”

Section: *Uv Spectrophotometrymentioning

confidence: 99%

“…This method does not involve any pretreatment (except filtration). Complex formationextraction or centrifugation steps are required with other instrumental methods [17][18][19]22,24,26].…”

Section: *Uv Spectrophotometrymentioning

confidence: 99%

“…The various methods include the use of spectrophotometry [15][16][17], spectrofluorimetry [18][19], high-performance liquid chromatography (HPLC) with UV detection [20], HPLC-ELSD (evaporative light scattering detection) [21], HPLC [22], potentiometric titration [23,24], conductometric titration [24], capillary electrophoresis [25], and luminescence [26].…”

Section: Introductionmentioning

confidence: 99%

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Properties of ibuprofen ion-selective electrodes based on the ion pair complex of tetraoctylammonium cation

Lenik

Wardak

2010

Open Chemistry

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Determination of ibuprofen in erythrocytes and plasma by high performance liquid chromatography

Cited by 32 publications

References 24 publications

Direct potentiometry and potentiotitrimetry of warfarin and ibuprofen in pharmaceutical preparations using PVC ferroin-based membrane sensors

Direct potentiometry and potentiotitrimetry of warfarin and ibuprofen in pharmaceutical preparations using PVC ferroin-based membrane sensors

Liquid chromatographic analysis of certain commercial formulations for non‐opioid analgesics

Properties of ibuprofen ion-selective electrodes based on the ion pair complex of tetraoctylammonium cation

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