Determination of ibuprofen and naproxen in tablets

Nanofiltration (NF) and reverse osmosis (RO) membranes have a high potential to remove low molecular weight trace contaminants in water that cannot be removed efficiently by conventional biological or physico-chemical treatments. However, membrane performance depends on several parameters involved in membrane synthesis. Multi-parameter optimization strategies, such as genetic algorithms (GAs) are extremely promising to minimize time and material consumption to direct membrane synthesis towards better separation properties (selectivity) of the targeted compounds combined with useful fluxes.Cellulose acetate membranes were prepared via phase inversion. The optimized parameters included compositional (polymer concentration, solvent) and also, for first time when using GA as optimization strategy in membrane synthesis, non-compositional on the level of the 2 membrane synthesis process and post treatment (temperature, annealing time), which have a great impact on membrane performance.Dead-end filtrations were carried out to evaluate membrane performance to retain ibuprofen in water by using High-Throughput experimentation (HT), which enables parallel testing and rapid acquisition of data sets and minimize time and material consumption. Ibuprofen was selected as it is one of the smallest molecules from relevant micropollutants present in drinking water. As result, membranes with ibuprofen retention up to 96% and permeabilities in the normal range of cellulose acetate (CA)-based reverse osmosis membranes were obtained, which also showed promising NaCl retention and twice the permeability compared to membranes prepared via a classical optimization parameter-by-parameter.

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“…[21] The intensity of the fluorescence emission at 290 nm was measured using quartz cells. The excitation wavelength was 224 nm.…”

Section: Equipmentmentioning

confidence: 99%

Optimization of cellulose acetate nanofiltration membranes for micropollutant removal via genetic algorithms and high throughput experimentation

Cano-Òdena

Spilliers

Dedroog

et al. 2011

Journal of Membrane Science

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“…However, a recent study classified naproxen as the least harmful NSAID in cardiovascular terms. 3 Different analytical methods have been proposed for the determination of naproxen in pharmaceutical formulations including spectrophotometry (UV region), 4,5 spectrofluorimetry, [6][7][8] capillary isotachophoresis 9 and high-performance liquid-chromatography (HPLC) coupled with spectrophotometric, 10 amperometric 11 and mass spectrometric detectors. 1 Nevertheless, these analytical methods require expensive equipment and reagents, are time-consuming and often necessitate laborious pre-and post-column derivatization procedures.…”

Section: Introductionmentioning

confidence: 99%

Fast determination of naproxen in pharmaceutical formulations by batch injection analysis with pulsed amperometric detection

Stefano¹,

Lima²,

Montes³

et al. 2012

J. Braz. Chem. Soc.

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Um método eletroanalítico original e rápido para a determinação de naproxeno em formulações farmacêuticas usando análise por injeção em batelada (BIA) com detecção amperométrica pulsada é descrito. Eletrodo de carbono vítreo foi usado como eletrodo de trabalho e solução tampão fosfato 0,05 mol L -1 como eletrólito suporte. O método amperométrico envolveu a aplicação contínua de dois pulsos de potencial ao eletrodo de trabalho com intuito de detectar naproxeno pela sua oxidação eletroquímica (+1,5 V por 200 ms) e de limpar a superfície do eletrodo de produtos de adsorção (+1,0 V por 100 ms), evitando contaminação do eletrodo. O método proposto possui várias vantagens para análises de rotina, incluindo: baixo desvio padrão relativo (3,0%, n = 10), elevada frequência analítica (90 h -1 ), exatidão satisfatória (baseado em determinações comparativas por espectrofluorimetria) e baixo limite de detecção (0,3 µmol L -1 ).A novel and fast electroanalytical method for naproxen determination in pharmaceutical formulations using batch injection analysis (BIA) with pulsed amperometric detection is described. Bare glassy carbon electrode was used as working electrode and 0.05 mol L -1 phosphate buffer solution as supporting electrolyte. The amperometric method involved the continuous application of two sequential potential pulses to the working electrode in order to detect naproxen by its electrochemical oxidation (+1.5 V for 200 ms) and to clean the electrode surface from adsorption products (+1.0 V for 100 ms), avoiding electrode contamination. The proposed method has several advantages for routine analysis, including: a low relative standard deviation between injections (3.0%, n = 10), high analytical frequency (90 h -1 ), satisfactory accuracy (based on comparative determinations by spectrofluorimetry) and low limit of detection (0.3 µmol L -1 ).Keywords: batch injection analysis, multiple-pulse amperometry, non-steroidal antiinflammatory drug IntroductionNaproxen, 2-(6-methoxynaphthalen-2-yl) propanoic acid, is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and has been widely used as an over-the-counter analgesic, anti-inflammatory and antipyretic agent. It is also commonly used for the reduction of stiffness caused by conditions including kidney stones, rheumatoid arthritis and other inflammatory rheumatic diseases. 1,2 NSAIDs have been associated with the increasing number of potentially cardiovascular events. However, a recent study classified naproxen as the least harmful NSAID in cardiovascular terms. 3 Different analytical methods have been proposed for the determination of naproxen in pharmaceutical formulations including spectrophotometry (UV region), 4,5 spectrofluorimetry, 6-8 capillary isotachophoresis 9 and high-performance liquid-chromatography (HPLC) coupled with spectrophotometric, 10 amperometric 11 and mass spectrometric detectors. 1 Nevertheless, these analytical methods require expensive equipment and reagents, are time-consuming and often necessitate laborious pre-and pos...

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“…Several analytical methods have been reported for the determination of naproxen in pharmaceutical preparations including UV-visible spectrophotomery, [3][4][5] spectrofluorimetry, [6][7][8] room temperature phosphorimetry, 9,10 voltametry, 11 high-performance liquid chromatography, [12][13][14] capillary electrophoresis, 15,16 coulometry 17 and oscilometric titration. 18 However, most of these techniques are timeconsuming, involving the use of organic solvents or require expensive and sophisticated instruments and for this reason they are not suitable for routine analysis.…”

Section: Introductionmentioning

confidence: 99%

A novel potentiometric naproxenate ion sensor immobilized in a graphite matrix for determination of naproxen in pharmaceuticals

Santini¹,

Oliveira²,

Pezza³

et al. 2006

J. Braz. Chem. Soc.

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As características, o desempenho e a aplicação de um eletrodo do tipo Pt⎪Hg⎪Hg 2 (NAP) 2 ⎪ Graphite, onde NAP=íon naproxenato, são descritas. O eletrodo responde a NAP com sensibilidade de (58,1± 0,9) mV década -1 no intervalo de 5,0 × 10 -5 -1,0 × 10 -2 mol L -1 , a pH 6,0-9,0 e com um limite de detecção de 3,9 × 10 -5 mol L -1 . O eletrodo é de baixo custo e facilmente construído, apresenta um rápido tempo de resposta (10-35 s) e pode ser usado por um período de seis meses sem qualquer divergência considerável nos potenciais. O sensor supracitado mostrou boa seletividade para naproxeno na presença de várias substâncias, tais como carboxilatos e ânions inorgânicos, sendo aplicado na análise direta de naproxeno em medicamentos (comprimidos) via método da adição de padrão. Os resultados analíticos obtidos com o eletrodo proposto estão em boa concordância com aqueles obtidos pelo procedimento preconizado na Farmacopéia Americana.The characteristics, performance, and application of an electrode, namely, Pt⎪Hg⎪Hg 2 (NAP) 2 ⎪ Graphite, where NAP stands for naproxenate ion, are described. This electrode responds to NAP with sensivity of (58.1± 0.9) mV decade -1 over the range 5.0 × 10 -5 -1.0 × 10 -2 mol L -1 at pH 6.0-9.0 and a detection limit of 3.9 × 10 -5 mol L -1 . The electrode is easily constructed at a relatively low cost with fast response time (within 10-35 s) and can be used for a period of 6 months without any considerable divergence in potentials. The proposed sensor displayed good selectivity for naproxen in the presence of several substances, especially concerning carboxylate and inorganic anions. It was used for the direct assay of naproxen in commercial tablets by means of the standard additions method. The analytical results obtained by using this electrode are in good agreement with those given by the United States Pharmacopeia procedure.Keywords: naproxenate-sensitive electrode, potentiometry, pharmaceutical formulations Introduction Naproxen [(+)-2-(6-metoxy-2naphthyl)propionic acid], is a non-steroidal anti-inflammatory drug that also presents analgesic and antipyretic properties often preferred to acetylsalicylic acid because of its better absortion following oral administration and fewer adverse effects.Naproxen is extensively used in the treatment of many diseases like rheumatoid arthrits, degenerative joint disease, ankylosing spondylits, acute gout and primary dismenorrea. 1 Like other non-steroidal anti-inflammatory drugs, it inhibits the biosyntesis of prostaglandins. 1 The United States Pharmacopeia 2 2003 reports an highperformance liquid chromatography (HPLC) method for the determination of naproxen tablets. Several analytical methods have been reported for the determination of naproxen in pharmaceutical preparations including UV-visible spectrophotomery, 3-5 spectrofluorimetry, 6-8 room temperature phosphorimetry, 9,10 voltametry, 11 high-performance liquid chromatography, 12-14 capillary electrophoresis, 15,16 coulometry 17 and oscilometric titration. 18 However, most of these techniq...

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Determination of ibuprofen and naproxen in tablets

Cited by 93 publications

References 19 publications

Optimization of cellulose acetate nanofiltration membranes for micropollutant removal via genetic algorithms and high throughput experimentation

Optimization of cellulose acetate nanofiltration membranes for micropollutant removal via genetic algorithms and high throughput experimentation

Fast determination of naproxen in pharmaceutical formulations by batch injection analysis with pulsed amperometric detection

A novel potentiometric naproxenate ion sensor immobilized in a graphite matrix for determination of naproxen in pharmaceuticals

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