Determination of Folic Acid by Adsorptive Stripping Voltammetry at a Lead Film Electrode

Abstract

An adsorptive stripping voltammetric procedure for the determination of folic acid at an in situ plated lead film electrode was described. Formation of lead film on a glassy carbon substrate and accumulation of folic acid was performed simultaneously from an acetate buffer solution of pH 5.6 at the potential À 0.88 V. The measurements were carried out from aerated solutions. The calibration graph for an accumulation time of 300 s was linear from 2 Â 10 À9 to 5 Â 10 À8 mol L À1. The detection limit was 7 Â 10 À10 mol L À1, the relative standard deviation for 2 Â 10 À8 mol L À1 of folic acid was 3.9%. The proposed procedure was applied to folic acid determinations in pharmaceutical preparations.

Application of a Carbon‐Paste Electrode Modified with 2,7‐Bis(ferrocenyl ethyl)fluoren‐9‐one and Carbon Nanotubes for Voltammetric Determination of Levodopa in the Presence of Uric Acid and Folic Acid

“…Several techniques have been applied for the determination of FA in pharmaceutical formulations and biological fluids. Due to the advantages of relatively low cost, fast response, simple instrumentation, high sensitivity, facile miniaturization, and low power requirement, numerous voltammetric methods have been developed for determination of FA [36][37][38][39][40][41].…”

A Solid Film Electrode of Intermetallic Ag2Hg3.02 for the Direct Determination of Folic Acid in Fresh and Processed Fruit Juices

“…There is only one work that determined FA in fresh orange juice (28.2 AE 1.3) mg/ 100 g, RSD = 1.3 %) without fortification using a calixarene based chemically modified electrode [32]. Table 2 shows a comparison between the results obtained in this study with those already published in the literature for the determination of FA in pharmaceuticals and fruit juices [11,14,15,23,24,[33][34][35][36].…”

“…The potential risks of poisoning, contamination and disposal associated with the use of mercury have led to the development of modified electrodes for the determination of many compounds, including FA, using carbon fiber microelectrode [10], lead film electrode [11], MIPsol-gel-modified PGE electrode [12], MIP -carbon composite fiber electrode [13], zirconia oxide (ZrO 2 ) nanoparticles-modified carbon paste electrode [14], modified carbon paste electrode with 2,2-[1,2buthanediylbis(nitriloethylidyne)]-bis and TiO 2 nanoparticles [15], carbon nanotubes paste electrode with ferrocenedicarboxylic Abstract: AgSIE was used for the direct analysis of folic acid (FA), with a detection limit and lower level of quantitation of 6. 8 acid [16], gold nanoparticles-modified carbon paste electrode (AuNPs/CPE) [17], ethynylferrocene modified carbon nanotubes paste electrode [18], carbon nanotube paste electrode (PBDCNPE) with 2,2'-[1,2-phenylenediylbis(nitrilomethylidene)]bis(4-hydroxyphenol) [19].…”

New Protocol for Determination of Rifampicine by Adsorptive Stripping Voltammetry

“…We have recently reported that folic acid is adsorbed at the lead film electrode [7]. Taking into account this fact we applied the proposed procedure for a folic acid determination.…”