Determination of Escitalopram Oxalate in Pharmaceutical Formulation by High Performance Liquid Chromatography

Charde, Manoj S.; Bhavsar, Nidhi; Chakole, R. D.

doi:10.7439/ijpc.v2i1.422

Cited by 5 publications

(3 citation statements)

References 10 publications

(6 reference statements)

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“…A study has been conducted on the "analytical procedures" used to determine "ESC and ETZ" as a single and multi-component. Single ESC UV-spectrophotometry [9], HPLC (High Performance Liquid Chromatography) [10][11][12][13], HPTLC [14]and single ETZ UV-spectrophotometry [15], HPLC [16,17]The combined study of ESC and ETZ of UV-spectrophotometry [18], HPLC [19], UPLC [20]. Based on the review of the literature, clearly stated that the combination of ESC and ETZ by HPTLC does not make a method.…”

Section: Introductionmentioning

confidence: 99%

Eco-friendly based stability-indicating HPTLC technique for the determination of Escitalopram and Etizolam by employing quality by design approach

Perumal

Krishnan

Lakshmi

2024

AChrom

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The two chemical components Escitalopram (ESC) and Etizolam (ETZ) are beneficial for the health of individuals because it helps to treat anxiety. The study mainly illustrated that a green approach is essential in the medical sector with the help of “Green Analytical quality by design”. According to AQbD, the techniques of HPTLC have become eco-friendly, and decided to use “ESC” and “ETZ”. Hence, ethanol and phosphate buffer pH 3.5 adjusted with 1% “orthophosphoric acid”. After the retardation factor, the product ESC was found at 0.34 min and ETZ was found at 0.53 min. The linearity of ETZ the range varies from 300 to 1800 μg mL−1 and for ESC it varies from 100 to 600 μg mL−1. The validation parameter of R2 Values ranged from 0.9997 to 0.9994 for both ESC and ETZ. The study also demonstrated that different other methods were also useful for the medical sector to make it more convenient and eco-friendly. Some of those approaches are “GAPI”, “AGMS”, “NEMI”, and “AGREE”. The outcome of the study helped to find that the technique “HPTLC” is a green analytic design that helps to maintain the stability of the medicine and it was also approved as a quality design and also a novel approach in the pharmaceutical sector.

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Section: Introductionmentioning

confidence: 99%

Eco-friendly based stability-indicating HPTLC technique for the determination of Escitalopram and Etizolam by employing quality by design approach

Perumal

Krishnan

Lakshmi

2024

AChrom

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“…It is freely soluble in methanol and Dimethylsulfoxide (DMSO). Escitalopram is a (S)-1- [3-(dimethylamino) propyl]-1-(4-fluorophenyl)-1, 3-dihydroisobenzofuran-5-carbonitrile 1,2 . The antidepressant and antiobsessive-compulsive actions of Escitalopram are presumed to be linked to its inhibition of CNS neuronal uptake of serotonin.…”

Section: Introductionmentioning

confidence: 99%

Spectrophotometric Determination of Escitalopram in Pharmaceuticals

Al-Ahmary¹

2013

Int J Pharmceut Chem

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ABSTRACT:A new, simple, fast and sensitive two spectrophotometric methods has been developed for determination of Escitalopram in bulk and tablet dosage forms. The method A is based on the oxidation of Escitalopram by a known excess of bromate-bromide mixture in hydrochloric acid medium, reduction of the residual oxidant by a fixed amount of iron(II) and the formation of iron(III)-thiocyanate-complex which is measured at 480 nm. In the method B, 1,10-phenanthroline is used as a complexing agent and the formation of iron(II)-1,10-phenanthroline, which is measured at 510 nm. The methods obeys Beer's law in the concentration range of 0.5 -8.0 µg mL -1 and 0.5-6.5 µg mL , respectively. The methods have been successfully applied to the determination of Escitalopram in pure and dosage forms.

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“…[3] Escitalopram oxalate was determined by different analytical methods such as spectrophotometry [4][5][6][7][8][9] and highperformance liquid chromatography. [10,11] In the present study, the authors have proposed three new spectrophotometric techniques for the assay of Escitalopram oxalate in tablets and validated as per the ICH guidelines. [12]…”

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confidence: 99%

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Annapurna¹

2018

IJGP

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Introduction: Escitalopram oxalate is an antidepressant drug. FDA has given approval for the treatment of major depressive disorder in adolescents and adults. New spectrophotometric techniques have been proposed for the determination of Escitalopram oxalate in sodium acetate buffer, borate buffer, and phosphate buffer (pH 6.8). Materials and Methods: Double beam UV-VIS spectrophotometer (SHIMADZU Model UV-1800) was used for the present study. Zero-order and first-order derivative spectrophotometric techniques have been developed for the determination of Escitalopram oxalate in sodium acetate buffer, borate buffer, and phosphate buffer. Results and Discussion: Escitalopram oxalate has shown absorption maxima at 238 nm in all the methods and linearity was observed 1.0-60 µg/ml in all the reagents such as sodium acetate buffer, borate buffer, and phosphate buffer and the methods were validated as per the ICH guidelines. Conclusions: These methods are simple, economical and can be successfully applied for the estimation of Escitalopram oxalate in pharmaceutical dosage forms.

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Determination of Escitalopram Oxalate in Pharmaceutical Formulation by High Performance Liquid Chromatography

Cited by 5 publications

References 10 publications

Eco-friendly based stability-indicating HPTLC technique for the determination of Escitalopram and Etizolam by employing quality by design approach

Eco-friendly based stability-indicating HPTLC technique for the determination of Escitalopram and Etizolam by employing quality by design approach

Spectrophotometric Determination of Escitalopram in Pharmaceuticals

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