Determination of eight nitrosamines in water at the ng L−1 levels by liquid chromatography coupled to atmospheric pressure chemical ionization tandem mass spectrometry

Ripollés, Cristina; Pitarch, Elena; Sancho, Juan V.; López, Francisco J.; Hernández, Félix

doi:10.1016/j.aca.2011.06.024

Cited by 75 publications

(47 citation statements)

References 32 publications

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“…Recent examples include Hung et al [20] and Llop et al [21]. The most common alternative to this has been analysis by high pressure liquid chromatography with tandem mass spectrometry (HPLC-MS/MS) [22][23][24]. Other advanced methods have included gas chromatography-high resolution mass spectrometry with EI [25] and nanoelectrospray ionisation (NSI) with high-field asymmetric waveform ion mobility spectrometry with time-of-flight mass spectrometry [26].…”

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confidence: 99%

Analysis of N-nitrosamines in water by isotope dilution gas chromatography–electron ionisation tandem mass spectrometry

McDonald

Harden

Nghiem

et al. 2012

Talanta

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, S. J. (2012). Analysis of N-nitrosamines in water by isotope dilution gas chromatography-electron ionisation tandem mass spectrometry. Talanta, Analysis of N-nitrosamines in water by isotope dilution gas chromatography-electron ionisation tandem mass spectrometry a b s t r a c t A method has been developed for the determination of eight N-nitrosamines in drinking water and treated municipal effluent. The method uses solid phase extraction (SPE), gas chromatography (GC) and analysis by tandem mass spectrometry (MS-MS) with electron ionization (EI). The target compounds are N-nitrosodimethylamine (NDMA), N-nitrosomethyethylamine (NMEA), N-nitrosodiethylamineThe use of direct isotope analogues for isotope dilution analysis of all analytes ensures accurate quantification, accounting for analytical variabilities that may occur during sample processing, extraction and instrumental analysis. Method detection levels (MDLs) were determined to describe analyte concentrations sufficient to provide a signal with 99% certainty of detection. The established MDLs for all analytes were 0.4-4 ng L À 1 in a variety of aqueous matrices. Sample matrices were observed to have only a minor impact on MDLs and the method validation confirmed satisfactory method stability over intra-day and inter-day analyses of tap water and tertiary treated effluent samples.

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confidence: 99%

Analysis of N-nitrosamines in water by isotope dilution gas chromatography–electron ionisation tandem mass spectrometry

McDonald

Harden

Nghiem

et al. 2012

Talanta

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“…They can be found at different levels in a variety of matrices such as ambient air [7], especially in atmospheric particulates as a result of direct emissions from polymer industry or combustion of rubber and plastic materials [8], foods [9], ground waters [10], tobacco [11], and cosmetics [12]. Humans have been exposed to N-nitroso compounds by two main ways; (a) exogenous sources such as diet, inhalation and/or involuntary ingestion, smoking and other environmental sources as well as (b) from the endogenous formation within the body, predominantly in the stomach [13], which has been related to an increased risk of gastric [2,14], oesophageal [2], nasopharyngeal, bladder, lung, and colon cancer [15].…”

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confidence: 99%

A chemometric optimization of method for determination of nitrosamines in gastric juices by GC–MS

Akyüz

Ata

Dinç

2016

Journal of Pharmaceutical and Biomedical Analysis

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“…Measurement of low concentrations of NDMA in different water matrices can be achieved by using highly sensitive and selective instrumental methods such as GC-MS/MS (Mitch and Sedlak 2002;Schmidt and Brauch 2008;Hu et al 2008;Andrzejewski and Nawrocki 2007;Planas et al 2008;Charrois et al 2007;Grebel et al 2006;Cheng et al 2006;Charrois et al 2004;Mitch et al 2003b;Taguchi et al 1994;Yoon et al 2011) and LC-MS/MS Ripolles et al 2011;Wang et al 2010;Kosaka et al 2009;Plumlee et al 2008;Krauss and Hollender 2008;Kodamatani et al 2009;Zhao et al 2006). However, the measurement of low concentrations of NDMA not only depends on the analytical detection limit of the LC or GC employed but also on the techniques (i.e., liquidliquid extraction (LLE) or solid-phase extraction (SPE)) that are used for the recovery and concentration of NDMA from the samples and for the elimination of matrix effects.…”

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A Practical LC-MS/MS Method for the Detection of NDMA at Nanogram per Liter Concentrations in Multiple Water Matrices

Topuz

Aydın

Pehlivanoğlu-Mantaş

2012

Water Air Soil Pollut

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N-nitrosodimethylamine (NDMA) is one of the most important disinfection by-products (DBPs) due to its carcinogenicity even at low concentrations which correspond to the levels occurring in drinking water and wastewater effluents. Therefore, NDMA is a candidate DBP that is expected to be regulated in the near future. However, the measurement of NDMA in the low nanogram per liter range is challenging because of the limitations of analytical techniques including both the sample preparation and the LC-MS/MS. Moreover, the accuracy of most of the current methods is only tested for drinking water and no information is present for other matrices. In this study, a combination of solidphase extraction (SPE) and LC-MS/MS method that does not require high-resolution MS or advanced techniques for sample pretreatment is developed. Moreover, important factors that affect the optimization of the SPE method are provided to enable readers to optimize their own SPE procedures if necessary. The proposed method was validated for surface water, groundwater, and wastewater samples and the method quantification limit was 2 ng/L. In addition, the proposed method was used to determine the concentration of NDMA precursors measured as NDMA formation potential (NDMAFP) throughout a drinking water treatment plant at two different sampling periods. NDMAFP decreased by approximately 40 % in both samples. The concentrations ranged between 4 and 11.5 ng/L and the presence of these low concentrations underlines the need for an easy to use, yet sensitive method for the determination of NDMA in environmental matrices.

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Determination of eight nitrosamines in water at the ng L−1 levels by liquid chromatography coupled to atmospheric pressure chemical ionization tandem mass spectrometry

Cited by 75 publications

References 32 publications

Analysis of N-nitrosamines in water by isotope dilution gas chromatography–electron ionisation tandem mass spectrometry

Analysis of N-nitrosamines in water by isotope dilution gas chromatography–electron ionisation tandem mass spectrometry

A chemometric optimization of method for determination of nitrosamines in gastric juices by GC–MS

A Practical LC-MS/MS Method for the Detection of NDMA at Nanogram per Liter Concentrations in Multiple Water Matrices

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