Determination of coagulation time in whole blood containing anticoagulant by piezoelectric quartz crystal sensor

Chang, Hsien Chang; Cheng, Tzong Jih; Wu, Tsui Hsun; Lin, Tsung-Han

doi:10.1016/s0925-4005(99)00462-1

Cited by 14 publications

(2 citation statements)

References 5 publications

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“…3 (a), the maximum frequency downshift Δf was observed decreased with the increase of TP concentration. The dependence of the maximum response on the activator concentration was in agreement with the results obtained from QCMs (Chang et al 2000;Cheng et al 1998;Vikinge et al 2000b), SPR (Vikinge et al 2000a) and the shear gradient-activated microfluidic device (Jain et al…”

Section: Discussionsupporting

confidence: 88%

Micro-electromechanical film bulk acoustic sensor for plasma and whole blood coagulation monitoring

Chen

Song

et al. 2017

Biosensors and Bioelectronics

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Monitoring blood coagulation is an important issue in the surgeries and the treatment of cardiovascular diseases. In this work, we reported a novel strategy for the blood coagulation monitoring based on a micro-electromechanical film bulk acoustic resonator. The resonator was excited by a lateral electric field and operated under the shear mode with a frequency of 1.9GHz. According to the apparent step-ladder curves of the frequency response to the change of blood viscoelasticity, the coagulation time (prothrombin time) and the coagulation kinetics were measured with the sample consumption of only 1μl. The procoagulant activity of thromboplastin and the anticoagulant effect of heparin on the blood coagulation process were illustrated exemplarily. The measured prothrombin times showed a good linear correlation with R=0.99969 and a consistency with the coefficient of variation less than 5% compared with the commercial coagulometer. The proposed film bulk acoustic sensor, which has the advantages of small size, light weight, low cost, simple operation and little sample consumption, is a promising device for miniaturized, online and automated analytical system for routine diagnostics of hemostatic status and personal health monitoring.

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Section: Discussionsupporting

confidence: 88%

Micro-electromechanical film bulk acoustic sensor for plasma and whole blood coagulation monitoring

Chen

Song

et al. 2017

Biosensors and Bioelectronics

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“…Besides, Castillo et al used diffuse reflectance sensor, optical fibers and 880 nm near-infrared radiation (NIR), to monitor goat's milk coagulation time [4]. Chang et al and Cheng et al both found the difference of resonance frequency between clotting/unclotting blood samples on a piezoelectric quartz crystal sensor [5,6]. Other physical methods are based on different types of ultrasound method, such as normal shear wave [7,8], air-couple [9], and pulse reflection technique [10] to determine the time period when the viscosity of blood changes in the coagulation process.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of holographic optical element module sensor in measuring blood prothrombin time

Lin

Yen

Cheng

et al. 2014

Meas. Sci. Technol.

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A small-form-factor holographic optical element (HOE) module, which was mounted on a dual-stage seesaw actuator, was utilized to evaluate blood coagulation in real time. The method involved assessing the decrease in transmitted light of the blood sample surface when the clotting is formed. The prothrombin time (PT) was measured by illumining and focusing a 635 nm laser beam onto the sample. As the fibrinogen turned into non-solute fibrin, the transmitted efficiency and total intensity of the reflected light from the reflector changed. A low-pass filter suppressed the noise in the coagulation-related transient response to yield accurate signals. Finally, the PT measurements were compared to those made classically using other optical sensors.

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Point of care (POC) blood coagulation monitoring technologies

Harris¹,

Lakshmanan

Efremov

et al. 2017

Medical Biosensors for Point of Care (POC) Applications

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Determination of coagulation time in whole blood containing anticoagulant by piezoelectric quartz crystal sensor

Cited by 14 publications

References 5 publications

Micro-electromechanical film bulk acoustic sensor for plasma and whole blood coagulation monitoring

Micro-electromechanical film bulk acoustic sensor for plasma and whole blood coagulation monitoring

Effectiveness of holographic optical element module sensor in measuring blood prothrombin time

Point of care (POC) blood coagulation monitoring technologies

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