Determination of Cd, Cu, Pb and Zn in neoplastic kidneys and in renal tissue of fetuses, newborns and corpses

Cerulli, Nicola; Campanella, Luigí; Grossi, R.; Politi, Laura; Scandurra, Roberto; Soda, Giuseppe; Gallo, Francesca; Damiani, S; Alimonti, Andrea; Petrucci, Francesco; Caroli, Sergio

doi:10.1016/j.jtemb.2006.03.002

Cited by 27 publications

(21 citation statements)

References 41 publications

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“…It is currently hypothesized that renal carcinogenesis due to lead uptake in the kidney is mediated by oxidative damage to the proximal renal tubule, where more than 95% of renal cell cancers develop (35, 36). Over three-fold higher concentrations of lead in renal cortex tissues of kidney cancer patients compared with cadaver controls have been reported, although the results of these studies are limited by their small number of subjects (37). In a representative sample of US residents, the NHANES III Mortality Study documented a higher rate of death from all causes as well as death from cardiovascular disease and cancer among participants ages 40 and older with blood lead levels above 5 ug/dL (cancer mortality HR=1.44, 95% CI: 1.12–1.86 for 5–9 ug/dL; HR=1.69, 95%CI: 1.14, 2.52 for ≥10 ug/dL versus <5 ug/dL, P trend <0.01; 8.5 years median follow-up time) (38).…”

Section: Discussionmentioning

confidence: 99%

Lead, Calcium Uptake, and Related Genetic Variants in Association with Renal Cell Carcinoma Risk in a Cohort of Male Finnish Smokers

Southard

Roff

Fortugno

et al. 2012

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background Lead (Pb) is classified as a probable human carcinogen. However, its role in renal cell cancer (RCC) has not been established. Calcium and vitamin D may off-set toxicity in vivo. Methods In this nested case-control study, whole blood lead (Pb), total serum calcium, and serum 25-hydroxyvitamin D were measured in blood drawn prior to diagnosis among male smokers participating in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Single nucleotide polymorphisms (SNPs) in five genes (CALB1, TRPV5, TRPV6, VDR, and ALAD) related to lead toxicity or calcium transport were genotyped. Logistic and linear regression were used to determine RCC risk and time to diagnosis (respectively), adjusting for other risk factors. Results Among 154 newly diagnosed cases and 308 matched controls, RCC was associated with higher whole blood lead (OR=2.0, 95% CI:1.0,3.9; quartile 4 (Q4) v. Q1, Ptrend=0.022) and CALB1 rs1800645 (Ptrend=0.025, minor ‘T’ allele frequency=0.34). Higher total serum calcium (Ptrend=<0.001) was associated with reduced RCC risk. Total serum calcium and 25-hydroxyvitamin D levels did not alter the association observed with lead. Time from enrollment to RCC diagnosis was positively associated with serum calcium (Ptrend=0.002) and 25-hydroxyvitamin D (Ptrend=0.054) among cases. Conclusions Higher blood lead concentrations, below the 10 ug/dL level of concern, were associated with RCC, independent from serum calcium and CALB1 promoter polymorphism. Impact Increased risk of RCC is associated with lower serum calcium and higher whole blood lead in smokers. The clinical prognostic value of serum calcium and vitamin D in RCC should be further investigated.

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Section: Discussionmentioning

confidence: 99%

Lead, Calcium Uptake, and Related Genetic Variants in Association with Renal Cell Carcinoma Risk in a Cohort of Male Finnish Smokers

Southard

Roff

Fortugno

et al. 2012

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…15 To broaden the application of mesoporous hybrid AAM, 5 assessment methods that can improve diagnostics in medical applications, health and safety, and security remain an attractive approach to analyze current ultra-trace levels of Hg(II) ion toxicity. [16][17][18][19][20] Moreover, toxic Hg(II) ions entering into rivers and soil as a result of exploitation abuse and smelting may progressively accumulate in humans after they become elaborated in bioactivities; as such, trace detection of Hg(II) ions is important. [21][22][23][24][25] Consequently, highly reliable, sustainable, easy-to-use, low-cost, and sensitive designs are necessary.…”

Section: Introductionmentioning

confidence: 99%

Mesosponge Optical Sinks for Multifunctional Mercury Ion Assessment and Recovery from Water Sources

El‐Safty

Sakai

Selim

et al. 2015

ACS Appl. Mater. Interfaces

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Using the newly developed organic-inorganic colorant membrane is an attractive approach for the optical detection, selective screening and removal, and waste management recovery of highly toxic elements, such as Hg(II) ions, from water sources. In the systematic mesosponge optical sinks (MOSs), anchoring organic colorants into 3D, well-defined cage cavities and interconnected tubular pores (10 nm) in the long microscale channels of membrane scaffolds enhances the requirements and intrinsic properties of the hierarchal membrane. This scalable design is the first to allow control of the multifunctional processes of a membrane in a one-step screening procedure, such as the detection/recognition, removal, and filtration of ultratrace Hg(II) ions, even from actual water sources (i.e., tap, underground). The selective recovery, detection, and extraction processes of Hg(II) ions in a heterogeneous mixture with inorganic cations and anions as well as organic molecules and surfactants are mainly dependent on the structure of the colorant agent, the pH conditions, competitive ion-system compositions and concentrations, and Hg-to-colorant binding events. Our result shows that the solid MOS membrane arrays can be repeatedly recycled and retain their hierarchal mesosponge sink character, avoiding fouling via the precipitation of metal salts as a result of the reuse cycle. The Hg(II) ion rejection and the permeation of nonselective elements based on the membrane filtration protocol may be key considerations in water purification and separation requirements. The selective recovery process of Hg(II) ions in actual contaminated samples collected from tap and underground water sources in Saudi Arabia indicates the practical feasibility of our designed MOS membrane arrays.

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“…Decline in the renal concentration function was revealed in 35% of children with recurrent pyelonephritis. Children with renal diseases are characterized by a considerable deficit of the main essential elements involved in functioning of antioxidant and immune systems [5,6,13,14]. Microelement homeostasis study results (tb.…”

Section: Resultsmentioning

confidence: 99%

Essential and Toxic Microelements in Clinical Presentation of Recurrent Pyelonephritis in Children

Мельникова¹,

Нагаева²,

Balasheva³

2013

Pediatr. farmakol.

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Determination of Cd, Cu, Pb and Zn in neoplastic kidneys and in renal tissue of fetuses, newborns and corpses

Cited by 27 publications

References 41 publications

Lead, Calcium Uptake, and Related Genetic Variants in Association with Renal Cell Carcinoma Risk in a Cohort of Male Finnish Smokers

Lead, Calcium Uptake, and Related Genetic Variants in Association with Renal Cell Carcinoma Risk in a Cohort of Male Finnish Smokers

Mesosponge Optical Sinks for Multifunctional Mercury Ion Assessment and Recovery from Water Sources

Essential and Toxic Microelements in Clinical Presentation of Recurrent Pyelonephritis in Children

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