Изучено состояние здоровья, вегетативный гомеостаз и параметры местного иммунитета 104 первоклассников в возрасте 6-8 лет в период адаптации к обучению в образовательных учреждениях общего типа и с повышенной учебной нагрузкой. Показано, что течение адаптационного процесса первоклассников, обучающихся в образовательных учреждениях нового типа, сопряжено с ростом хронической патологии, нарушением вегетативного гомеостаза и состояния местного иммунитета слизистых оболочек (увеличение содержания секреторного иммуноглобулина A, снижение активности каспазы-3 слюны), свидетельствующими о снижении неспецифической резистентности организма детей.Ключевые слова: первоклассники, комплексная оценка здоровья, адаптация, вегетативный гомеостаз, каспаза-3, секреторный иммуноглобулин A слюны.The state of health, vegetative homeostasis and parameters of local immunity 104 first-graders at the age of 6-8 years in adaptation to training in educational institutions of the general type and with the raised academic load is studied. It is shown that the current of adaptable process of the first-graders trained in educational institutions of new type is interfaced to growth of a chronic pathology, infringement of a vegetative homeostasis and a condition of local immunity of mucous membranes (maintenance increase sekretori immunoglobulin A, activity decrease kaspazy-3 a saliva), testifying to decrease in nonspecific resistance of an organism of children.
Hen’s egg allergy is one of the most common problems in pediatrics. This pathology is associated with severe clinical manifestations, often with a risk of anaphylactic reactions. This review presents current data on the epidemiology and clinical presentation, as well as aspects of the natural history and management of hen’s egg allergy. The paper will provide data on allergenic proteins of hen’s egg, including data on structure, physicochemical properties, IgE-binding capacity, and cross-reactivity. Finally, practical information about egg allergy and immunization will be presented.
The aim of the research. To study the features of cardiovascular system disorders in post-covid syndrome (PCS) in children and adolescents after a mild form of coronavirus infection (COVID-19). Material and methods. From 260 children and adolescents after a mild form of COVID-19, a total of 30 patients aged 7–17 years with cardiac manifestations of PCS were selected. Therewith, 32 patients with an uncomplicated form of the disease were selected to form a comparison group. In 3 and 6 months after disease onset, a comprehensive examination of patients was performed with a questionnaire on the subjective scale for MFI-20 assessment asthenia (Multidimensional Fatigue Inventory-20), electrocardiography (ECG), echocardiography; daily monitoring of ECG and blood pressure. The biochemical blood test included assay of creatine phosphokinase-MB (CPK-MB), troponin I and lactate dehydrogenase (LDH). Results. The incidence of PCS with cardiac manifestations amounted to 11.5 %. After 3 months from the disease onset, complaints of pain and discomfort in the chest, palpitations, fatigue, and poor exercise tolerance persisted. Asthenic syndrome was diagnosed in 70 % of patients. The “general asthenia” indicator totalled14 [12; 16] points (p<0.001) and was associated with the age of patients (r=+0.5; p<0.05). Arrhythmic syndrome and conduction disorders were detected in 67% of children. Labile arterial hypertension and hypotension occurred in 23 % of the adolescents. The increase in CPK-MB remained in 17% of the children, LDH – in 10%. In the sixth month after the onset of the disease, there were no significant differences in the results of the examination in the observation groups. However, a decrease in the level of resistance within 6 months was recorded in 43.3% of the schoolchildren with PCS (p<0.001). Conclusion. The data obtained indicate the need for early verification of cardiopathies in children with COVID-19, determination of a set of therapeutic and rehabilitation measures as well as ECG monitoring.
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