Determination of binding capacity and adsorption enthalpy between Human Glutamate Receptor (GluR1) peptide fragments and kynurenic acid by surface plasmon resonance experiments

Csapó, Edit; Majláth, Zsófia; Juhász, Ádám; Roósz, Balázs; Hetényi, Anasztázia; Tóth, Gábor; Tajti, János; Vécsei, László; Dékány, Imre

doi:10.1016/j.colsurfb.2014.10.046

Cited by 14 publications

(11 citation statements)

References 22 publications

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“…The facilitatory effect is probably associated with a positive modulatory binding site at the AMPA receptors. A recent work provided data relating to the possible molecular mechanisms, but further investigations are definitely warranted [ 63 ]. KYNA has been identified as a ligand for the previously orphan G-protein-coupled receptor too [ 64 ].…”

Section: Kynurenic Acidmentioning

confidence: 99%

Memantine and Kynurenic Acid: Current Neuropharmacological Aspects

Majláth¹,

Török²,

Toldi³

et al. 2016

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Glutamatergic neurotransmission, of special importance in the human brain, is implicated in key brain functions such as synaptic plasticity and memory. The excessive activation of N-methyl- D-aspartate (NMDA) receptors may result in excitotoxic neuronal damage; this process has been implicated in the pathomechanism of different neurodegenerative disorders, such as Alzheimer’s disease (AD). Memantine is an uncompetitive antagonist of NMDA receptors with a favorable pharmacokinetic profile, and is therefore clinically well tolerated. Memantine is approved for the treatment of AD, but may additionally be beneficial for other dementia forms and pain conditions. Kynurenic acid (KYNA) is an endogenous antagonist of NMDA receptors which has been demonstrated under experimental conditions to be neuroprotective. The development of a well-tolerated NMDA antagonist may offer a novel therapeutic option for the treatment of neurodegenerative disease and pain syndromes. KYNA may be a valuable candidate for future drug development.

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Section: Kynurenic Acidmentioning

confidence: 99%

Memantine and Kynurenic Acid: Current Neuropharmacological Aspects

Majláth¹,

Török²,

Toldi³

et al. 2016

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show abstract

“…Naturally, the thermodynamic state functions are standard values as presented in Table 1. (corrections: page 1, abstract; page 3, line 1; page 8, line 27; page 10, line 18,23,25,26). However, the K A is also standard value, but according to IUPAC nomenclature both the K A and the K A° are also suitable.…”

Section: " the Equations (8) And (9) Are Basic Thermodynamic Equationmentioning

confidence: 99%

Thermodynamic and kinetic characterization of pH-dependent interactions between bovine serum albumin and ibuprofen in 2D and 3D systems

Csapó

Juhász

Varga

et al. 2016

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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“…Values for ΔH°, ΔS° and ΔCp of the interaction between the immobilized BSA and KYNA (8) were calculated to be −1.94 ± 0.25 kJmol -1 , 25.8 ± 0. [15,16,19] gives an evidence of the existing of specific binding affinity and way between KYNA and earliest investigated AMPA receptor peptide fragments.…”

Section: Discussionmentioning

confidence: 99%

“…Besides quantitation of the interactions, the enthalpy change of the binding process on certain peptide fragment-modified gold surfaces were also reported [15,16]. In the present work, instead of relatively small model peptide fragments, the HSA and BSA proteins were immobilized onto the sensor surface and their interactions with KYNA were investigated by SPR technique.…”

Section: Introductionmentioning

confidence: 99%