Determination of binary mixture of ibuprofen and famotidine by different spectrophotometric methods

Abstract

Four simple and specific spectrophotometric methods were developed and validated for the simultaneous determination of binary mixture of ibuprofen and famotidine, using unified regression equation. The proposed spectrophotometric procedures including, derivative ratio, ratio subtraction, dual wavelength and mean centering of ratio spectra do not require any separation steps. Accuracy, precision and linearity ranges of the proposed methods were determined and the specificity was assessed by analysing synthetic mixtures of both drugs. The methods were applied to a pharmaceutical formulation and the results obtained showed that there is no significant difference between the proposed methods and the reported one regarding both accuracy and precision. KEYWORDS

Universal procedures for spectrophotometric determination of anticoccidial drugs; application to multi-ingredient veterinary formulation and computational investigations for multivariate analysis

“…This method can be applied to determine the ternary mixture of the investigated compounds whose spectra show a severe overlap [22,23]. It is based on the principles of both the ratio difference method [34][35][36] and the dual wavelength method [37][38][39][40]. The proposed method can determine a ternary mixture, such that every compound can be selectively determined after total elimination of the impediment caused by the other two compounds.…”