Determination of Antioxidant and Antidiabetic Activities of Polar Solvent Extracts of Daedaleopsis confragosa (Bolton) J. Schröt

Bioactivity Profiling of Daedaleopsis confragosa (Bolton) J. Schröt. 1888: Implications for Its Possible Application in Enhancing Women’s Reproductive Health

“…However, the anticipated low extraction yield was in line with expectations due to the characteristic of D. confragosa being a woody mushroom with minimal moisture content [37]. The results of Chandrawanshi et al [38] depicted hot water as the best extracting solvent for D. confragosa, with a recovery percentage of 50.00, followed by EtOH (3.65%), while methanol (MeOH) provided only 2.70%. This is in accordance with the study where the highest yields for both basidiocarp/mycelial extracts of the same species were achieved using hot water extraction (21.9 ± 1.1% and 15.9 ± 0.7%, respectively).…”

“…On the other hand, the 50% EtOH extracts of D. confragosa from Croatia exhibited much lower neutralization of the DPPH radical (IC 50 = 0.015 ± 0.07 mg/mL) [37], while the MeOH extracts of D. confragosa from India had even lower anti-DPPH activity of IC 50 = 4.8 mg/mL [42]. Moreover, the EtOH extract of this species collected in India exhibited higher DPPH scavenging ability (IC 50 of 18.07 ± 0.02 µg/mL), together with high redox capacity, compared to the hot water extracts, which gained higher yields [38], confirming the previously reported data [41] that the yield values are not directly related to their qualitative efficiency. Additionally, the variation in the antioxidant capacity, as well as the content of the bioactive compounds, may also be linked to factors such as the geographical origin, ecology, and genotype of the species [4,40].…”