Determination of antidepressant activity of &lt;i&gt;Cyperus rotundus&lt;/i&gt; L extract in rats

Hao, Guifeng; Mao-qin, Tang; Wei, Yan-jin; Che, Fengyuan; Li-ju, Qian

doi:10.4314/tjpr.v16i4.17

Cited by 11 publications

(6 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…From the above information, we can therefore conclude that the test extract was found to reduce the depression level of rodents in the TST efficiently. A similar result was obtained in the case of Eclipta alba, Cyperusrotundus L, Channastriatus, methanol extract of Micromeriamyrtifolia , and Glycyrrhizin in TST [ 6 , 62 , 63 , 64 ].…”

Section: Discussionsupporting

confidence: 80%

“…Paw edema in rats induced by carrageenan is a standard experimental measurement (shown in Eq. (2) ) that develops in only a few hours and is related directly to the release of kinins, prostaglandins, histamine, and serotonin [ 63 , 64 , 65 , 66 ]. In Table 4 , the standard drug, T. arjuna extract, significantly reduces edema formation in low, medium, and high doses.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

An evaluation of pharmacological healing potentialities of Terminalia Arjuna against several ailments on experimental rat models with an in-silico approach

Tahsin

Sultana

Khan

et al. 2021

Heliyon

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

An evaluation of pharmacological healing potentialities of Terminalia Arjuna against several ailments on experimental rat models with an in-silico approach

Tahsin

Sultana

Khan

et al. 2021

Heliyon

View full text Add to dashboard Cite

“…[33][34][35][36][37][38][39][40][41][42][44][45][46]65 anti-viral, anti-inflammatory, anti-tumor, neuroprotective, anti-asthmatic, anti-oxidant, hepatoprotective, immunomodulator, anti-platelet, analgesic, bioavailability enhancer, cardioprotective , neuroprotective, antibacterial Cyperus rotundus Linn. [47][48][49][50][51][52][53][55][56][57][58][59] anti-oxidant, anti-ulcer, analgesic, anti-microbial, cytotoxic, anti-convulsant, anti-diabetic, anti-diarrheal, antispasmodic, anti-inflammatory, hepatoprotective, cardioprotective, anti-lipidemic, anti-platelet, antidepressant, neuroprotective In albino-wistar rats, the acute toxicity experiment showed that the drug did not produce any signs and symptoms of toxicity (or mortality) up to the dose of 2000 mg/kg 2.…”

Section: Medicinal Plantmentioning

confidence: 99%

Balchaturbhadra churna as a potential medicine for SARS-Cov2 infection in pediatric setting: An In-Silico study

Choudhary¹,

Thrigulla²,

Gundeti³

et al. 2022

Preprint

View full text Add to dashboard Cite

Background: Balchaturbharda Churna (BC), is four ingredients (Aconitum heterophyllum Wall. Ex Royle, Pistacia integerrima stew. Ex brandis, Piper Longum Linn. and Cyperus rotundus linn.) Ayurvedic powder dosage form, which is commonly prescribed for treating fever, cough, diarrhea in pediatric setting.Objective: This present study evaluates the possible effect of phytochemicals from the ingredients of BC on SARS-CoV-2 main protease (MPro), RNA dependent RNA polymerase (RdRP) and spike-ACE2 (SA) complex through in silico evaluation. Materials and methods: X-ray crystal structure of MPro and SA complex with PDB IDs 6LU7 and 6LZG and the SWISS model of RdRP were used as the drug targets. An enhanced docking methodology has been implemented to perform the molecular docking of these phytochemicals against the above-mentioned drug targets of SARS-CoV-2. DOCK 6 was used to perform docking of these phytochemicals. The ADMET and drug likeliness properties for these selected phytochemicals was performed using SWISS ADME. Results: The ensemble docking studies suggest that aconitine, lappaaconitine from Aconitum heterophyllum, 2’-hydroxyisorientin from Pistacia intergerrima and guineesine, pipercide and piperoic acid from Piper longum hold the potential to bind favorably with the SARS-CoV-2 drug targets. The drug likeliness and ADMET properties were calculated for these phytochemicals indicate that all the three phytochemicals from Piper longum were observed to have considerate drug-likeliness and ADMET properties. Aconitine has molecular weight slightly higher than 500 kDA and has more than 10 hydrogen bond acceptors. Conclusion: The in-silico study demonstrates that phytochmeicals from the ingredients BC viz., aconitine, lappaaconitine from Aconitum heterophyllum, 2’-hydroxyisorientin from Pistacia intergerrima and guineesine, pipercide and piperoic acid from Piper longum hold the potential to bind favourably with the SARS-CoV-2 drug targets. The study also provides evidence for drug likeliness and ADMET properties for these phytochemicals suggesting that BC can be further studied as potential drug of choice for treating SARS-CoV-2 infection in paediatric cases.

show abstract

“…[18] Ethanolic extract of Cyperus rotundas has proven for its anxiolytic, antidepressant and hypnotic effect in mice. [19] Embelica officinalis is known for neuroprotective and memory enhancing activities. [20] Nilumbo nucifera flowers extract at all doses used in a study showed the enhanced neuron density in hippocampus together with the improved spatial memory in stress induced rodents.…”

Section: Drug Reviewmentioning

confidence: 99%

Efficacy of Draksadi Phantam in Generalized Anxiety Disorder- An Uncontrolled Clinical Trial

PM¹,

et al. 2022

Int J Ayu Pharm Res

View full text Add to dashboard Cite

Anxiety disorders are one of the most prevalent class of mental disorders in the general population. Generalized anxiety disorder (GAD) is a common anxiety disorder that comprises continuous and long-lasting worrying, tension, which making normal life problematic and relaxation impossible The prevalence rate of GAD disorder is increasing constantly in modern era. Though many different types of modern medications used currently to treat anxiety disorders provide temporary relief, they come with various side effects, Drug dependence and safety concerns. In Ayurveda the symptoms of this disease show resemblance with the condition. Cittodvega (excited state of mind) which is one among the Manovikara in Ayurveda caused by dysfunction of increased Vata and Pitta dosha. The present study was conducted as an Uncontrolled clinical trial to study the Efficacy of Drakshadi Phantam in 38 diagnosed participants of Generalized Anxiety Disorder with the age group 20–50 were administered with 100ml of Drakshadi Phantam twice daily before food continuously for a period of 45 days. Five assessments were done staring from 0th day of treatment to 60 the day of the study with a gap of 15 days, using Hamilton anxiety rating scale and Rajas Tams rating scale. The assessment scores of different intervals were statistically analysed using RM ANOVA. Effect of the therapy were statistically analysed in each domain of HAM – A rating scale in different intervals of the study. The therapy was found statistically significant in reducing the symptoms of GAD in all the 14 domains of the HAM- A Rating scale. Based on results it has been concluded that Drakshadi Phantam has statistically significant effect in reducing the symptoms of all the 14 domains of Hamilton anxiety rating scale and reducing the Rajasika and Tamasika qualities of the study participants.

show abstract

Determination of antidepressant activity of <i>Cyperus rotundus</i> L extract in rats

Abstract: Purpose: To investigate the antidepressant effect of Cyperus rotundus L. extract (CRLE) in rats.

Cited by 11 publications

References 12 publications

An evaluation of pharmacological healing potentialities of Terminalia Arjuna against several ailments on experimental rat models with an in-silico approach

An evaluation of pharmacological healing potentialities of Terminalia Arjuna against several ailments on experimental rat models with an in-silico approach

Balchaturbhadra churna as a potential medicine for SARS-Cov2 infection in pediatric setting: An In-Silico study

Efficacy of Draksadi Phantam in Generalized Anxiety Disorder- An Uncontrolled Clinical Trial

Contact Info

Product

Resources

About