Determination of amikacin in body fluid by high-performance liquid-chromatography with chemiluminescence detection

Serrano, João; Silva, Manuel

doi:10.1016/j.jchromb.2006.05.016

Cited by 42 publications

(28 citation statements)

References 27 publications

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“…This is because the amikacin molecule has fewer points susceptible to enzymatic attack than most other aminoglycosides (Chen, Chen, He, Shang, & Zhang, 2012;Nicoli & Santi, 2006;Serrano & Silva, 2006;Yu, He, Fu, Xie, & Gan, 2009), and hence has a broader antibiotic spectrum.…”

Section: Introductionmentioning

confidence: 99%

“…When used in the treatment of cow mastitis, adequate withdrawal periods are required to avoid the occurrence of amikacin residues in the milk (Chen et al, 2012). This is important because amikacin has earlier been reported to have potential ototoxicity (Kitasato, Yokota, Inouye, & Igarashi, 2004;Zawilla et al, 2007) and nephrotoxicity (Luft et al, 1978;Serrano & Silva, 2006).…”

Section: Introductionmentioning

confidence: 99%

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Development of a monoclonal antibody assay and immunochromatographic test strip for the detection of amikacin residues in milk and eggs

Isanga

Mukunzi

Suryoprabowo

et al. 2017

Food and Agricultural Immunology

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An amikacin-sensitive monoclonal antibody (MAb) assay and immunochromatographic test strip were developed and applied for the detection of amikacin residues in bovine milk and chicken eggs. The immunoassay was specific to amikacin and showed no cross-reactivity with other aminoglycosides. The half maximum inhibitory concentration (IC 50 ) of the assay was 0.65 ng/mL and the results were obtained within 90 min. Recoveries from spiked food matrices were within the range of 73.55-84.61% for bovine milk and 73.70-105.75% for whole egg. The strip test results were obtained within 10 min and showed a visual detection limit of 5.0 ng/mL for both food matrices. These results show that the MAb immunoassay and strip test developed in this study are very specific to amikacin and sufficiently sensitive for detection and routine monitoring of amikacin residues in food. ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development of a monoclonal antibody assay and immunochromatographic test strip for the detection of amikacin residues in milk and eggs

Isanga

Mukunzi

Suryoprabowo

et al. 2017

Food and Agricultural Immunology

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“…Amikacin sulfate is quantitatively determined through various analytical techniques such as spectrophotometry, 4-8 spectroflourimetry 9-13 and HPLC methods. [14][15][16][17][18][19][20][21][22][23][24][25] The aminoglycoside antibiotic activity can be increased by association with Herbs like activity by Pityrogramma calomelanos (L.). 26 The spectroscopic method for assay of amikacin sulfate is not official in any pharmacopoeia.…”

Section: Introductionmentioning

confidence: 99%

Quantitative determination of amikacin Sulfate using vanillin from pure and commercial brands available in Pakistan

Mughal¹,

Dayo²,

Ghoto³

et al. 2015

J YOUNG PHARM

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Objective: To determine the amikacin sulfate by developing a new spectrophotometric method by derivatization using double beam spectrophotometer from pure and commercial brands. Method: A quantitative analytical method was developed by amikacin sulfate using spectrophotometer after derivatization with vanillin under optimized parameters like pH, heating time and temperature, volume of reagent, Impact of mixing order, Effect of addition of solvents and Effect of excipients. The method was successfully applied on bulk and different brands containing amikacin sulfate. Results: The bulk and pharmaceutical analysis was carried out of different brands with formation of slight yellow colored imine base. The product showed absorbance at 400 nm w i t h molar absorptivity of 5.

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“…[1] Monitoring of amikacin levels in plasma is required for therapeutic and toxic control, so a simple, sensitive and specific method for trace analysis in plasma is essential. Some methods have been adopted for the determination of amikacin, including immunoassay, [2] spectrophotometry, [3] fluorescence method, [4][5][6] liquid chromatography, [1,[7][8][9][10][11] capillary electrophoresis [12] and CL [13] voltammetry. [14] Because of lack of volatility and chromophore, most methods use derivatization to produce volatile, UV-vis absorbing or fluorescent derivatives.…”

Section: Introductionmentioning

confidence: 99%

New luminol chemiluminescence reaction using diperiodatoargentate as oxidate for the determination of amikacin sulfate

2009

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A new chemiluminescence (CL) reaction between luminol and diperiodatoargentate [K(2) [Ag (H(2)IO(6)) (OH)(2)]] was observed in alkaline medium. The CL intensity could be greatly enhanced by amikacin sulfate. Therefore a new CL method for the determination of amikacin sulfate was built by combining with flow injection technology. A possible mechanism of the CL reaction was proposed via the investigation of the CL kinetic characteristics, the CL spectrum and the UV absorption spectra of some related substance. The concentration range of linear response was 5.1 x 10(-8) to 5.1 x 10(-6)mol L(-1) with a detection limit of 1.9 x 10(-8) mol L(-1) (3sigma). The proposed method had good reproducibility with a relative standard deviation of 2.8% (n = 7) for 5.1 x 10(-7) mol L(-1) of amikacin sulfate. It was successfully applied to determine amikacin sulfate in serum.

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Determination of amikacin in body fluid by high-performance liquid-chromatography with chemiluminescence detection

Cited by 42 publications

References 27 publications

Development of a monoclonal antibody assay and immunochromatographic test strip for the detection of amikacin residues in milk and eggs

Development of a monoclonal antibody assay and immunochromatographic test strip for the detection of amikacin residues in milk and eggs

Quantitative determination of amikacin Sulfate using vanillin from pure and commercial brands available in Pakistan

New luminol chemiluminescence reaction using diperiodatoargentate as oxidate for the determination of amikacin sulfate

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