Determination of acrylamide in drinking water by large-volume direct injection and ion-exclusion chromatography–mass spectrometry

Cavalli, Stefano; Polesello, Stefano; Saccani, G.

doi:10.1016/j.chroma.2004.01.010

Cited by 48 publications

(25 citation statements)

References 3 publications

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“…On the one hand, in the latter approach an additional concentrations step could be included, but on the other hand the strong UV absorbance of the water matrix at 200 nm (e. g., huminic acids) might impede the detection of AA. A strong decrease in detection limits down to an LOD of 0.2 lg/L can be achieved by ion-exclusion chromatography-MS [7]. Thus, this method meets the requirements of WHO and EPA, yet it lacks the sensitivity demanded for the EU Drinking Water Directive.…”

Section: Introductionmentioning

confidence: 86%

Rapid and sensitive determination of acrylamide in drinking water by planar chromatography and fluorescence detection after derivatization with dansulfinic acid

Alpmann

Morlock²

2008

J of Separation Science

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On the basis of a novel derivatization, a new planar chromatographic method has been developed for the determination of acrylamide (AA) in drinking water at the ultra-trace level. After SPE, the water extracts were oversprayed on a high-performance thin-layer chromatography (HPTLC) silica gel plate with the derivatization agent dansulfinic acid and derivatized in situ. Chromatography was performed with ethyl acetate and the fluorescent product was quantified at 366/>400 nm. Verification was based on HPTLC-ESI/MS, HPTLC-direct analysis in real-time (DART)-TOF/MS and NMR. The routine HPTLC-fluorescence detection (FLD) method was validated for spiked drinking water. The regression analysis was linear (r >0.9918) in the range of 0.1-0.4 microg/L. LOD was calculated to be 0.025 microg/L and experimentally proved for spiked samples at levels down to 0.05 microg/L (S/N = 6) which was suited for monitoring the EU limit value of 0.1 microg/L in drinking water (0.5 microg/L demanded by World Health Organization (WHO)/US Environmental Protection Agency (EPA)). Within-run precision and the mean between-run precision (RSD, n = 3, three concentration levels each) were evaluated to be 4.8 and 11.0%, respectively. The mean recovery (0.1, 0.2, and 0.3 microg/L) was 96% corrected by the internal standard. The method, in comparison with HPLC-MS/MS showed comparable results and demonstrated the accuracy of the method.

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Section: Introductionmentioning

confidence: 86%

Rapid and sensitive determination of acrylamide in drinking water by planar chromatography and fluorescence detection after derivatization with dansulfinic acid

Alpmann

Morlock²

2008

J of Separation Science

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“…With the advent of commercialized mass spectrometers fitted with multiple stage vacuum systems and with more efficient atmospheric pressure ionization (API) sources, higher LC flow rates, larger column diameters and larger injection volumes were made possible. An increasing number of publications have since appeared in the scientific literature that describe SC-LVI for use with mass spectrometry for the determination of pesticides in vegetables [20], water [21][22][23][24][25][26][27][28][29], and soil [30][31][32][33]; fluorochemicals in wastewater, groundwater and surface water [33][34][35][36][37]; neurotoxins in surface water, groundwater and drinking water [38,39]; pharmaceuticals (legal and/or illicit) in surface, ground, and waste water [25,33,[40][41][42][43][44]; corrosion inhibitors in surface, ground, and waste water [33,45]; chelating agents in surface, drinking, and waste water [46]; iodinated chemicals in waste water and treated water [47][48][49]; artificial sweeteners in ground, waste, and treated water [50]; biocides in surface and waste water [51]; bisphenol A in soil [33]; steroids in waste water [52]; and surfactants in seawater (unpublished) ( Table 2). The success and popularity of SC-LVI compared to ON-E and CC-LVI are most likely due to its sim...…”

Section: The History Of Large-volume or Direct-injectionmentioning

confidence: 99%

Trace analysis of environmental matrices by large-volume injection and liquid chromatography–mass spectrometry

et al. 2011

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The time-honored convention of concentrating aqueous samples by solid-phase extraction (SPE) is being challenged by the increasingly wide spread use of large-volume injection (LVI) liquid chromatography-mass spectrometry (LC-MS) for the determination of traces of polar organic contaminants in environmental samples. Although different LVI approaches have been proposed over the last 40 years, the simplest and most popular way of performing LVI is known as single column LVI (SC-LVI), in which a large-volume of an aqueous sample is directly injected into an analytical column. For the purposes of this critical review, LVI is defined as an injected sample volume that is ≥ 10% of the void volume of the analytical column. Compared to other techniques, SC-LVI is easier to set up, as it only requires small hardware modifications to existing autosamplers and, thus, will represent the main focus of the current review. Although not new, SC-LVI is gaining acceptance and the approach is emerging as a technology that will render SPE nearly obsolete for many environmental applications. In this review, we discuss 1) the history and development of various forms of LVI, 2) the critical factors that one needs to consider when creating and optimizing SC-LVI methods and 3) example applications that demonstrate the range of environmental matrices, to which LVI is applicable such as drinking water, groundwater and surface water including seawater as well as wastewater. Furthermore, we give responses to answer a set of 'frequently asked questions' typically encountered from audiences and we indicate future directions and areas that need to be addressed to fully delineate the limits of SC-LVI.

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“…Analytical techniques based on liquid chromatography were proposed in the literature in order to quantify, by direct injection, acrylamide in water samples (Cavalli et al 2004;Marín et al 2006;US EPA 1994) (Table 1). The analytical method proposed by the US EPA (1994) based on liquid chromatography and UV detection is appropriate to quantify acrylamide concentration greater than 10 μg/L.…”

Section: Introductionmentioning

confidence: 99%

“…The analytical method proposed by the US EPA (1994) based on liquid chromatography and UV detection is appropriate to quantify acrylamide concentration greater than 10 μg/L. Searching sub-ppb levels of acrylamide, corresponding to the regulated concentrations for drinking water (0.1 μg/L) (European Council 1998), liquid chromatography with MS (Cavalli et al 2004) or MS/MS detection (Marín et al 2006) and direct injection were used. The detection limits determined for the direct methods were satisfactory compared to the regulated value, but these methods requested important injection volumes and were not tested on complex matrixes such as pore water.…”

Section: Introductionmentioning

confidence: 99%

Direct injection method for HPLC/MS/MS analysis of acrylamide in aqueous solutions: application to adsorption experiments

Mnif

Hurel

Marmier

2014

Environ Sci Pollut Res

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Polyacrylamides are polymers used in many fields and represent the main source of release of the highly toxic acrylamide in the environment. In this work, a simple, rapid, and sensitive analytical method was developed with HPLC/MS/MS and direct injection for acrylamide analysis in water and adsorption samples. AFNOR standards NF T90-210 and NF T90-220 were used for the analytical method validation and uncertainty estimation. Limit of quantification (LOQ) for acrylamide was 1 μg/L, and accuracy was checked at three acrylamide levels (1, 6, and 10 μg/L). Uncertainties were estimated at 34.2, 22, and 12.4 % for acrylamide concentrations at LOQ, 6 μg/L, and 10 μg/L, respectively. Acrylamide adsorption on clays (kaolinite, illite) and sludge was then studied as a function of pH, time, and acrylamide concentrations. Acrylamide adsorption on kaolinite, illite, and sludge was found to be very weak since adsorption percentages were inferior to 10 %, whatever the pH value and the initial acrylamide concentration. The low affinity of acrylamide for clays and sludge is likely due to its hydrophilic property, small size, and charge neutrality.

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Determination of acrylamide in drinking water by large-volume direct injection and ion-exclusion chromatography–mass spectrometry

Cited by 48 publications

References 3 publications

Rapid and sensitive determination of acrylamide in drinking water by planar chromatography and fluorescence detection after derivatization with dansulfinic acid

Rapid and sensitive determination of acrylamide in drinking water by planar chromatography and fluorescence detection after derivatization with dansulfinic acid

Trace analysis of environmental matrices by large-volume injection and liquid chromatography–mass spectrometry

Direct injection method for HPLC/MS/MS analysis of acrylamide in aqueous solutions: application to adsorption experiments

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