Determination of acidity constants of curcumin in aqueous solution and apparent rate constant of its decomposition

Bernabé-Pineda, Margarita; Ramı́rez-Silva, Maria Teresa; Romero-Romo, M.; González‐Vergara, Enrique; Rojas-Hernándéz, Alberto

doi:10.1016/s1386-1425(03)00342-1

Cited by 192 publications

(115 citation statements)

References 20 publications

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“…A first factor to keep into account is the different solubility as a function of pH. Indeed curcumin molecules (pK a1 = 8.38, pK a2 = 9.88 and pK a3 = 10.51) can exist as cationic, neutral or anionic species in acidic, neutral or alkaline solution, respectively (Bernabé-Pineda et al, 2004). Therefore, curcumin can be easily migrated out of the carrier at pH 1 in its cationic form, resulting in a higher release as compared with that at pH 5.0 and 8.0.…”

Section: Release Kineticsmentioning

confidence: 99%

Development and characterization of co-loaded curcumin/triazole-halloysite systems and evaluation of their potential anticancer activity

Riela

Massaro

Colletti

et al. 2014

International Journal of Pharmaceutics

109

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Section: Release Kineticsmentioning

confidence: 99%

Development and characterization of co-loaded curcumin/triazole-halloysite systems and evaluation of their potential anticancer activity

Riela

Massaro

Colletti

et al. 2014

International Journal of Pharmaceutics

109

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“…It has been shown that curcumin has three pKa values at 8⋅38, 9⋅88 and 10⋅51 in aqueous solution, corresponding to deprotonation of the three hydroxyl groups (figure 1). 18,19 Therefore, curcumin is fully protonated at pH 6 to form the highly positively charged species. Therefore interaction of this species with the negative charges on the protein is highly likely.…”

Section: Surface Tension Changes In Collagen On Interaction With Curcmentioning

confidence: 99%

Directed 2-dimensional organisation of collagen: Role of cross-linking and denaturing agents

Fathima

Dhathathreyan

Ramasami³

2010

J Chem Sci

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The effect of additives like curcumin and surfactants on the self-assembly of collagen from a simple 2-dimensional system of Langmuir films of the protein at air/solution interface has been attempted in this study using quartz crystal microbalance (QCM) and dynamic surface tensiometer. Though pure curcumin is not surface active, a synergistic effect of collagen with curcumin seems to lead to enhanced surface activity in the protein. In general, the presence of additives, increases the surface activity of collagen even for the lowest concentration and the largest change in surface activity is seen for collagen with sodium dodecyl sulfate (SDS). The results suggest interplay between the unexposed hydrophobic groups, and the opening out and solvation of the more charged or polar groups at the surface leading to aggregation followed by self-assembly. Modulation of aggregation at interface in collagen due to these additives may be an approach that could be explored for possible applications in bio-materials and for delivery of protein-drug complexes.

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“…While in a different study reported by Bernabé-Pineda et al, it was concluded that, at high pH values (>11.7), there was an improvement in the stability of CUR [60] . At a pH of 7.4, there was a rapid degradation of CUR.…”

Section: Can These Bioavailability Issues Of Cur Be Resolved?mentioning

confidence: 82%

Multifaceted Role of a Marvel Golden Molecule, Curcumin: a Review

Moselhy¹,

Razvi²,

Hasan³

et al. 2018

pharmaceutical-sciences

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Moselhy, et al.: Multifaceted Role of CurcuminCurcumin is chemically known as diferuloylmethane, which is an important nutraceutical obtained from the yellow spice Curcuma longa. It has been used traditionally as a folklore medicine in countries like India, China and Thailand for nearly 2000 years without any prior knowledge of the mechanism of action. Cellbased studies and clinical trials that have been reported so far have provided evidence that curcumin could be effectively used as antimicrobial, anticancer, antidiabetic, antiinflammatory, antimalarial and antioxidant. There are more than 9400 articles published on this "magical molecule" till date. Furthermore, nearly 100 clinical trials have been done using curcumin, which demonstrated safety, efficacy and prophylactic activity of curcumin. On the molecular level, curcumin has shown to modulate several crucial and significantly interlinked pathways in rendering an optimistic outcome against life-threatening diseases like cancer, diabetes, lupus nephritis, and other autoimmune and neurodegenerative diseases. In this communication, the chemical structure, biological properties and possible molecular targets of curcumin have been reviewed along with some recent developments in drug delivery systems of curcumin.

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Determination of acidity constants of curcumin in aqueous solution and apparent rate constant of its decomposition

Cited by 192 publications

References 20 publications

Development and characterization of co-loaded curcumin/triazole-halloysite systems and evaluation of their potential anticancer activity

Development and characterization of co-loaded curcumin/triazole-halloysite systems and evaluation of their potential anticancer activity

Directed 2-dimensional organisation of collagen: Role of cross-linking and denaturing agents

Multifaceted Role of a Marvel Golden Molecule, Curcumin: a Review

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