Multifaceted Role of a Marvel Golden Molecule, Curcumin: a Review

Abstract

Moselhy, et al.: Multifaceted Role of CurcuminCurcumin is chemically known as diferuloylmethane, which is an important nutraceutical obtained from the yellow spice Curcuma longa. It has been used traditionally as a folklore medicine in countries like India, China and Thailand for nearly 2000 years without any prior knowledge of the mechanism of action. Cellbased studies and clinical trials that have been reported so far have provided evidence that curcumin could be effectively used as antimicrobial, anticancer, antidiabetic, antiinflammatory, antimalarial and antioxidant. There are more than 9400 articles published on this "magical molecule" till date. Furthermore, nearly 100 clinical trials have been done using curcumin, which demonstrated safety, efficacy and prophylactic activity of curcumin. On the molecular level, curcumin has shown to modulate several crucial and significantly interlinked pathways in rendering an optimistic outcome against life-threatening diseases like cancer, diabetes, lupus nephritis, and other autoimmune and neurodegenerative diseases. In this communication, the chemical structure, biological properties and possible molecular targets of curcumin have been reviewed along with some recent developments in drug delivery systems of curcumin.

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Curcuma Longa, the “Golden Spice” to Counteract Neuroinflammaging and Cognitive Decline—What Have We Learned and What Needs to Be Done

“…Within this latter organ the increased curcumin bioavailability might counteract cognitive decline. Figure adapted with permission from [ 119 ]. Copyright © 2018, Said Moselhi.…”

Enhancement of Annexin V in response to combination of epigallocatechin gallate and quercetin as a potent arrest the cell cycle of colorectal cancer

“…The protective effect of natural compounds may be attributed to the presence of numerous phytochemicals such as resveratrol, quercetin, rutin, catechin, myricetin, kaempferol, and Epigallocatechin gallate (EGCG). EGCG has been reported to modulate multiple key elements in signal transduction pathways affecting cellular proliferation, differentiation, apoptosis, inflammation, angiogenesis and metastasis in CRC (Araujo et al, 2011;Kuerban et al, 2017;Soengas Fernández et al, 2011;Moselhy et al, 2018). Initial studies have revealed that these compounds are able to affect cell proliferation, cell cycle regulation, and usually participate in multiple signaling pathways which are often disrupted in tumor initiation, proliferation and propagation (Kotecha et al, 2016).…”