Determinants of quality of life in patients with psoriasis: A study from the US population

Gelfand, Joel M.; Feldman, Steven R.; Stern, Robert S.; Thomas, J. Y.; Rolstad, Tara; Margolis, David J.

doi:10.1016/j.jaad.2004.04.014

Cited by 327 publications

(314 citation statements)

References 19 publications

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“…Psoriasis, a chronic, recurrent, immune‐mediated inflammatory disorder,1, 2 impairs quality of life (QoL)3, 4 to a similar extent to that experienced by patients with other chronic diseases such as diabetes or cancer 5. Although many patients with mild‐to‐moderate psoriasis are treated with topical therapy alone,6, 7, 8 adherence remains a significant issue as the daily treatment regimen can be cumbersome and time consuming 9.…”

Section: Introductionmentioning

confidence: 99%

Calcipotriol plus betamethasone dipropionate aerosol foam provides superior efficacy vs. gel in patients with psoriasis vulgaris: randomized, controlled PSO‐ABLE study

Paul

Gold

Cambazard

et al. 2016

Acad Dermatol Venereol

102

167

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BackgroundFixed combination calcipotriol 50 μg/g (Cal) plus betamethasone 0.5 mg/g (BD) foam has been developed as a new treatment option for patients with psoriasis.MethodsThe randomized, parallel‐group, investigator‐blinded Phase III, 12‐week PSO‐ABLE study compared the efficacy and safety of Cal/BD foam with Cal/BD gel. Patients aged ≥18 years with mild‐to‐severe psoriasis were randomized 4:4:1:1 to once‐daily Cal/BD foam, Cal/BD gel, foam vehicle or gel vehicle (NCT02132936). The primary efficacy endpoint was the proportion of patients who were clear/almost clear with a ≥ 2 grade improvement according to the physician's global assessment of disease severity (i.e. treatment success) at week 4 for Cal/BD foam vs. week 8 for Cal/BD gel. Secondary efficacy endpoints included: proportion of patients achieving at least a 75% reduction in modified psoriasis area and severity index (mPASI75), and time to treatment success (TTTS). Safety was monitored throughout.ResultsA total of 463 patients were randomized: Cal/BD foam (n = 185), Cal/BD gel (n = 188), foam vehicle (n = 47), gel vehicle (n = 43); overall completion rate was 90%. Cal/BD foam achieved higher treatment success rates (38% vs. 22%; P < 0.001) and mPASI75 (52% vs. 35%; P < 0.001) by week 4 than Cal/BD gel by week 8. Median TTTS with Cal/BD foam was 6 weeks; this could not be determined for Cal/BD gel as 50% treatment success was not achieved (P < 0.001). Adverse drug reactions were reported in 14 (7.6%) Cal/BD aerosol foam patients and 7 (3.7%) Cal/BD gel patients; all were single events except for itch with Cal/BD aerosol foam (n = 5; 2.7%) and worsening psoriasis with Cal/BD gel (n = 3; 1.6%).ConclusionCal/BD aerosol foam showed significantly greater efficacy after 4 weeks, than 8 weeks of treatment with Cal/BD gel, with similar tolerability.

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Section: Introductionmentioning

confidence: 99%

Calcipotriol plus betamethasone dipropionate aerosol foam provides superior efficacy vs. gel in patients with psoriasis vulgaris: randomized, controlled PSO‐ABLE study

Paul

Gold

Cambazard

et al. 2016

Acad Dermatol Venereol

102

167

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“…Bununla birlikte Gelfand ve ark. tarafından kadınlardaki işlev kaybı derecesinin erkeklere göre daha fazla olduğu saptanmıştır 6 . Psoriasisin kadınlarda muhtemelen kozmetik önem oluşturması nedeniyle yaşam kalitesini erkeklere göre daha fazla etkilemesi beklenebilir.…”

Section: Discussionunclassified

“…Yaşam kalitesi üzerinde büyük bir etki yaratabilmesi nedeniyle psoriasis şiddetinin tanımlanmasında fiziksel, psikolojik ve sosyal bileşenlerin birlikte göz önünde bulundurulması gerekmektedir [1][2][3][4][5][6][7][8] . Psoriasisli olgularda hastalık şiddetinin değerlendirilmesi öznel ve nesnel ölçüm metodları ile birlikte karışık bir klinik süreçtir.…”

Section: Introductionunclassified

“…Son zamanlarda psoriasis şiddetinin bozulmuş fiziksel ve sosyal fonksiyonlar ve psikolojik stres ile ilişkilendirilmesi üzerinde durulmuş, psoriasisli olgularda farklı indekslerle yapılan çeşitli çalışmalarda yaşam kalitesinin değişik açılardan etkilenebildiği gösterilmiştir. Bu çalışmalarda psoriasisin yaşam kalitesine etkisini değerlendirmek için genel, dermatolojik hastalıklara yönelik ve/veya psoriasise özgün indeksler kullanılmıştır [1][2][3][4][5][6][7][8] . Psoriasise özgün indekslerden ilki Psoriasis İşlev Kaybı İndeksi (PİKİ, "Psoriasis Disability Index") olup 1987 yılında Finlay ve ark.…”

Section: Introductionunclassified

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Psoriasis disability index: The role of sociodemographic and clinical variables

Akarsu¹,

Aktan²,

Demirtaşoğlu³

et al. 2014

TURKDERM

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Background and Design:A variety of studies have demonstrated that psoriasis can affect psychological, social and physical functions. The purpose of this study was to determine the impact of the sociodemographic and clinical characteristics on Psoriasis Disability Index (PDI), which is a psoriasis-specific health-related quality of life instrument. Materials and Methods: A total of 70 patients with psoriasis were included in this study and sociodemographic features of the patients, psoriasis area severity index scores evaluated by physician and patient (PASI and SAPASI) and the presence of subjective symptoms associated with psoriasis were recorded. In addition, the patients were asked to complete a questionnaire (PDI) consisting of a series of 15 questions related to daily activities, work/school, personal relationships, leisure and treatment, dealing with the past four weeks. Correlations between PDI and its subscale scores with sociodemographic and clinical features were analyzed. Results: There were statistically significant positive correlations between mean PDI scores and both of mean PASI and SAPASI scores. Activities of leisure and work/school were found to be more effected in men than in women. PDI and daily activities, personal, work/school and/or leisure activities were also detected to be more effected in patients with cosmetic involvement, severe psoriasis, long duration of disease (≥10 years) and young age of onset. In addition, in patients with subjective symptoms, such as pruritus, muscle pain and fatigue, personal relations, daily and work/school activities were found to be negatively affected. Conclusion: In this study, mean PDI scores correlated significantly both with clinical severity and sociodemographic variables. Nevertheless, we assume that addition of questions examining quality of life related to subjective symptoms such as pruritus would be appropriate. (Turkderm 2014; 48: 187-92)

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“…The chronic nature of the disease and the lack of control over unexpected outbreaks of the symptoms are among the most bothersome aspects of psoriasis [7]. Patients may feel humiliated when they need to expose their bodies during intimate relationships, swimming, using public showers, or anyway living in conditions that do not provide adequate privacy [8].…”

Section: Introductionmentioning

confidence: 99%