Determinants of Postpartum Vitamin D Status in the Caucasian Mother-Offspring Pairs at a Latitude of 52°N: A Cross-Sectional Study

Czech‐Kowalska, Justyna; Gruszfeld, Dariusz; Jaworski, Maciej; Bulsiewicz, Dorota; Latka-Grot, Julita; Pleskaczyńska, Agata; Lygas, Justyna; Wygledowska, Grazyna; Pawlus, Beata; Zochowska, Anna; Borszewska−Kornacka, Maria Katarzyna; Dobrzańska, Anna

doi:10.1159/000437099

Cited by 13 publications

(9 citation statements)

References 41 publications

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“…Recent studies of breastfeeding women in other countries have also shown a high prevalence of inadequate vitamin D status [18, 20, 21]; however, the prevalence was often lower than those rates found in our study [17, 22]. For example, in Sweden, the prevalence of 25(OH)D concentrations < 50 nmol/L in women, who were breastfeeding for 12 months, was 22% in the winter months (November to April) and 15% in the summer months [17].…”

Section: Discussionmentioning

confidence: 99%

Breastfeeding woman are at higher risk of vitamin D deficiency than non-breastfeeding women - insights from the German VitaMinFemin study

2016

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BackgroundDespite increased awareness of the adverse health effects of vitamin D deficiency, only a few studies have evaluated the vitamin D status (25-hydroxyvitamin D [25(OHD)]) of breastfeeding women and up to now, no information exits for German breastfeeding women. Therefore, the aim of study was to determine the vitamin D status of breastfeeding women compared to non-pregnant and non-breastfeeding (NPNB) women.MethodsThis cross-sectional study investigated 124 breastfeeding women and 124 age and season matched NPNB women from the German “Vitamin and mineral status among German women” study. The study participants were recruited from April 2013 to March 2015 and did not take vitamin D supplements. Serum 25(OH)D was analyzed by chemiluminescent immunoassay.ResultsVitamin D deficiency (<25.0 nmol/L) was prevalent in 26.6% of the breastfeeding women. The majority of women (49.2%) showed 25(OH)D concentration between 25.0 and 49.9 nmol/L. In multiple binary logistic regression analysis, breastfeeding women had a 4.0-fold higher odds ratio (OR) (95% confidence interval [CI] 1.8, 8.7) for vitamin D deficiency than NPNB women. For breastfeeding women, the risk of vitamin D deficiency was higher in the winter and spring months (OR: 2.6, 95% CI 1.1, 6.3) and increased with lower longitude per one unit (OR 0.7, 95% CI 0.6, 0.9).ConclusionBreastfeeding women in Germany had a higher risk of deficient vitamin D levels than NPNB women. In further studies, the optimal vitamin D status for breastfeeding women should be investigated and also the required vitamin D doses to ensure this vitamin D status.Trial registrationGerman Clinical Trial Register (identification number: DRKS00004789).

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Section: Discussionmentioning

confidence: 99%

Breastfeeding woman are at higher risk of vitamin D deficiency than non-breastfeeding women - insights from the German VitaMinFemin study

2016

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“…Seasonal variation of vitamin D predominates in regions with higher latitude and better defined seasons, such as, for example, in European countries such as Ireland (52° N) or Poland (52° N), with lower concentrations of vitamin D during winter [ 19 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

“…In our study, despite low frequency of vitamin D supplementation during pregnancy, postpartum deficiency was lower than other studies with similar population. The fact of our study has been performed in a place with high insolation rate, during the spring and summer seasons, and women often expose themselves to the sun could be explain this lower prevalence of deficiency found [ 20 , 22 , 23 ]. The collection of 25(OH)D within the first 24 hours of delivery may also justify this finding; it is known that pregnant women have about twice as much more circulating vitamin D metabolites compared to nonpregnant women [ 6 , 19 ].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Postpartum Concentrations: Relationship with Nutritional Condition and Morbidities during Pregnancy

Martins

Esmeraldo

Sabiá

et al. 2018

Journal of Pregnancy

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Objective To evaluate postpartum vitamin D deficiency/insufficiency and to relate it to pregestational BMI, gestational weight gain, and sociodemographic variables. Methods This is a cross-sectional study with 225 full-term pregnant women. Data collected are as follows: maternal health, socioeconomic status, pregestational body mass index (BMI), and gestational weight gain. Laboratory evaluation included vitamin D [25(OH)D], calcium, phosphorus, magnesium, and alkaline phosphatase. Results The mean age of women was 25.6±6.6 years. Dark skin color, low education, and work in the urban region were predominant. Regular sun exposure, photoprotection, and vitamin D supplementation were reported by 144 (64.0%), 44 (19.6%), and 5 (2.2%) women, respectively. The mean plasma concentrations of 25(OH)D were 26.0±6.8 ng/mL. Levels compatible with deficiency (<20 ng/mL) and insufficiency (20-30 ng/mL) were observed in 43 (19.1%) and 124 (55.1%) women, respectively. The increase of 1 ng/mL in 25(OH)D concentrations was associated with an increase of 0.16 mg/dL (95%CI 0.19 to 2.02; p=0.018) for calcium. There were no associations with 25(OH)D concentrations with pregestational BMI and with gestational weight gain. Conclusions The high frequency of postpartum vitamin D deficiency/insufficiency in women with a full-term pregnancy in a region with a large and permanent sun exposure reminds us of the need for intervention policies aimed at preventing vitamin D deficiency during pregnancy.

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“…Additionally, we found that craniotabes increased the risk of lower BMC by 4 times; however, it was present in only 34% of the infants with lower BMC. Craniotabes might be a clinical sign of bone demineralisation due to calcium, phosphate or vitamin D deficiency, but of limited diagnostic accuracy [23, 24]. …”

Section: Discussionmentioning

confidence: 99%

The Clinical and Biochemical Predictors of Bone Mass in Preterm Infants

et al. 2016

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BackgroundMetabolic bone disease of prematurity still occurs in preterm infants, although a significant improvement in neonatal care has been observed in recent decades. Dual-energy X-ray absorptiometry (DXA) is the precise technique for assessing bone mineral content (BMC) in preterm infants, but is not widely available.AimTo investigate the clinical and biochemical parameters, including bone metabolism markers as potential predictors of BMC, in preterm infants up to 3 months corrected age (CA).Materials and MethodsCa-P homeostasis, iPTH, 25-hydroxyvitamin D, osteocalcin, N-terminal propeptide, cross-linked C-telopeptide and amino-terminal pro C-type natriuretic peptide and the DXA scans were prospectively performed in 184 preterm infants (≤ 34 weeks’ gestation) between term age and 3 mo CA. Lower bone mass was defined as BMC below or equal to respective median value for the whole study group, rounded to the nearest whole number.ResultsThe appropriate quality DXA scans were available for 160 infants (87%) examined at term and for 130 (71%) tested at 3 mo CA. Higher iPTH level was the only independent predictor of lower BMC at term, whereas lower BMC at 3 mo CA was associated both with lower urinary phosphate excretion and higher serum osteocalcin level. ROC analysis showed that iPTH >43.6 pg/mL provided 40% sensitivity and 88% specificity in identification of preterm infants with lower BMC at term. In turn, urinary phosphate excretion (TRP>97% or UP/Cr ≤0.74 mg/mg) and serum osteocalcin >172 ng/mL provided 40% sensitivity and 93% specificity in identification of infants with decreased BMC at 3 mo CA.ConclusionSerum iPTH might to be a simple predictor of reduced BMC in preterm infants at term age, but urinary phosphate excretion and serum osteocalcin might predict reduced BMC at 3 mo CA. These results represent a promising diagnostic tool based on simple, widely available biochemical measurements for bone mass assessment in preterm infants.

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Determinants of Postpartum Vitamin D Status in the Caucasian Mother-Offspring Pairs at a Latitude of 52°N: A Cross-Sectional Study

Cited by 13 publications

References 41 publications

Breastfeeding woman are at higher risk of vitamin D deficiency than non-breastfeeding women - insights from the German VitaMinFemin study

Breastfeeding woman are at higher risk of vitamin D deficiency than non-breastfeeding women - insights from the German VitaMinFemin study

Vitamin D Postpartum Concentrations: Relationship with Nutritional Condition and Morbidities during Pregnancy

The Clinical and Biochemical Predictors of Bone Mass in Preterm Infants

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