Determinants of isolated systolic hypertension in the elderly

Nichols, Wilmer W.; Nicolini, Fabio; Pepine, Carl J.

doi:10.1097/00004872-199208001-00020

Cited by 100 publications

(75 citation statements)

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“…However, ISH in younger and older individuals can be distinguished clearly on the basis of PP amplification. 58,59 In the elderly (Ͼ60 years old), ISH is associated with increased aortic stiffness, early return of reflected waves, thus smaller PP amplification. 58 Nonetheless, aged individuals with ISH should be treated.…”

Section: Clinical Implications Of Pulse Pressure Amplificationmentioning

confidence: 99%

Role of Pulse Pressure Amplification in Arterial Hypertension

et al. 2009

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Section: Clinical Implications Of Pulse Pressure Amplificationmentioning

confidence: 99%

Role of Pulse Pressure Amplification in Arterial Hypertension

et al. 2009

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“…Sex hormones such as estrogen may be one of the reasons for this phenomenon. PP is affected by two major factors: the interaction between the ventricular ejection and the viscoelastic properties of the large arteries (direct), and the wave reflection (indirect) (13)(14)(15). The former indicates that high PP reflects an increase in large-artery (aortic) stiffness.…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular Risk Factors Associated with Pulse Pressure in a Screened Cohort in Okinawa, Japan.

et al. 2003

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We evaluated the association between pulse pressure (PP) and cardiovascular risk factors in a screened cohort. Individuals who were receiving medications for hypertension or heart disease, who had no ECG record, or who had a record of arrhythmia were excluded. In total, 8,508 subjects (5,299 men and 3,209 women; age range, 18 to 89 years) were studied. Subjects were divided into four PP classes: PP.1 (PP 40 mmHg, n 2,127), PP.2 (40 PP 44 mmHg, n 2,127), PP.3 (44 PP 50 mmHg, n 2,127) and PP.4 (50 mmHg PP, n 2,127). Multiple regression analysis was used for evaluating the association between PP and cardiovascular risk factor or lifestyle. In men, the regression coefficient was 0.27 for age, 2.50 for diabetes mellitus, 0.33 for uric acid, 0.20 for body mass index, 0.07 for heart rate, 0.83 for current smoking habit and 1.23 for habitual drinking. In women, the regression coefficient was 0.37 for age, 4.09 for diabetes mellitus, 0.42 for body mass index, 0.14 for heart rate, and 0.84 for habitual exercise. In both men and women, PP was significantly increased in association with an increase in the number of risk factors (diabetes mellitus, obesity, current drinking status, heart rate, and hyperuricemia). In conclusion, higher PP was associated with cardiovascular risk factors. These associations were similar in both men and women. older subjects, is an independent predictor of coronary heart disease (3-7). In their prospective population-based study, the Framingham group found that cardiovascular mortality, and particularly coronary mortality, was independently related with initial SBP, DBP, and PP, and that PP showed the strongest association (8). Therefore, the goal of the present study was to evaluate the association of PP with classical cardiovascular risk factors in a screened cohort in Okinawa, Japan.

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“…Patients with hypertension exhibit greater carotid wall thickness, 20 central arterial stiffness, 21 and central pressure augmentation 22 than normotensive subjects, even after adjusting for age. They are thought to have higher central arterial diameters, 23 although this is presently debated.…”

Section: Arterial Aging In Cardiovascular Diseasesmentioning

confidence: 91%

Arterial Aging

2005

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Abstract-Age is the dominant risk factor for cardiovascular diseases. However, until recently, convincing mechanistic or molecular explanations for the increased cardiovascular risks conferred by aging have been elusive. Aging is associated with alterations in a number of structural and functional properties of large arteries, including diameter, wall thickness, wall stiffness, and endothelial function. Emerging evidence indicates that these age-associated changes are also accelerated in the presence of cardiovascular diseases, and that these changes are themselves risk factors for the appearance or progression of these diseases. In this review, the evidence demonstrating that arterial aging is accelerated in cardiovascular diseases and that accelerated arterial aging is a risk factor for adverse cardiovascular outcomes is briefly reviewed, and selected advances in vascular biology that provide insights into the mechanisms that may underlie the increased risks conferred by arterial aging are summarized. Remarkably, a host of biochemical, enzymatic, and cellular alterations that are operative in accelerated arterial aging have also been implicated in the pathogenesis and progression of arterial diseases. These vascular alterations are thus putative candidates that could be targeted by interventions aimed at attenuating arterial aging, similar to the lifestyle and pharmacological interventions that have already been proven effective. Therefore, the notion that aging is a chronological process and that its risky components cannot be modulated is no longer tenable. It is our hope that a greater appreciation of the links between arterial aging and cardiovascular diseases will stimulate further investigation into strategies aimed at preventing or retarding arterial aging.

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Determinants of isolated systolic hypertension in the elderly

Cited by 100 publications

References 0 publications

Role of Pulse Pressure Amplification in Arterial Hypertension

Role of Pulse Pressure Amplification in Arterial Hypertension

Cardiovascular Risk Factors Associated with Pulse Pressure in a Screened Cohort in Okinawa, Japan.

Arterial Aging

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