Arterial Aging

Najjar, Samer S.; Scuteri, Angelo; Lakatta, Edward G.

doi:10.1161/01.hyp.0000177474.06749.98

Cited by 566 publications

(242 citation statements)

References 104 publications

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“…Carotid diastolic diameter in middle-aged men was higher than that in young men. This result was consistent with the results of a previous epidemiological study (31). This alteration may be a physiological adaptation to suppress marked reductions in arterial compliance and vessel diameter induced by hypertrophied IMT with advancing age.…”

Section: Discussionsupporting

confidence: 93%

Attenuated Increases in Blood Pressure by Dynamic Resistance Exercise in Middle-Aged Men

et al. 2008

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The present study was performed to test the hypothesis that the blood pressure (BP) response to resistance exercise in middle-aged men with stiffening arteries is greater than that in young men with compliant arteries. The BP responses to acute dynamic resistance exercise (leg press) at individual relative (low, moderate and high) and absolute intensities were investigated in both young and middle-aged men. A total of 21 sedentary healthy normotensive men, 21-25 years of age (young) and 41-59 years of age (middle-aged), were included in the study. At rest, the arterial compliance (simultaneous ultrasound and applanation tonometry) and muscle strength (leg press) were lower, and indices of arterial stiffness and BP were higher in the middle-aged men than in the young men (p <0.05). There were no significant differences in height, body mass, or heart rate between the two groups. During exercise, the systolic BP of the middle-aged men at 80% onerepetition maximum (1RM) was significantly lower than that of the young men for the last half of the exercise

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Section: Discussionsupporting

confidence: 93%

Attenuated Increases in Blood Pressure by Dynamic Resistance Exercise in Middle-Aged Men

et al. 2008

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“…With ageing, the walls of the elastic arteries stiffen and the important volume buffering function and pressure absorbing function is diminished 2 . This results in an increase in systolic and a decrease in diastolic blood pressure, thereby amplifying the pulse pressure (PP).…”

Section: Introductionmentioning

confidence: 99%

Predictive markers of abdominal aortic stiffness measured by echo-tracking in subjects with varying insulin sensitivity

2014

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Predictive markers of abdominal aortic stiffness measured by echo-tracking in subjects with varying insulin sensitivity. Link to publication Citation for published version (APA): Gottsäter, M., Länne, T., & Nilsson, P. M. (2014). Predictive markers of abdominal aortic stiffness measured by echo-tracking in subjects with varying insulin sensitivity. Journal of Human Hypertension, 28(7), 456-460. DOI: 10.1038456-460. DOI: 10. /jhh.2013 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal AbstractArterial stiffness is influenced by advancing age and vascular disease and is an independent risk factor for cardiovascular events and death. Using ultrasound measurements, arterial stiffness in a specific arterial segment can be assessed. The aim of this observational study was to explore the prospective and cross-sectional associations between arterial stiffness measured by ultrasound locally in the abdominal aorta and cardiovascular risk factors/markers including insulin resistance measured by the homeostatic model assessment -insulin resistance (HOMA-IR), lipids and abdominal obesity.This study includes 335 subjects from Malmö, Sweden, examined in 1991 and again at follow-up in 1998-2000. Ultrasound measurement of the abdominal aorta was performed at follow-up investigation.In the female subgroup, there was a positive association between HOMA-IR at baseline and abdominal aortic stiffness at follow-up (beta=0.18, p=0.03) and a negative association between high density lipoprotein and aortic stiffness (beta=-0.23, p=0.005), independently of classical cardiovascular risk factors. These associations were not found among men. The results suggest a greater or different role of impaired glucose metabolism in the pathophysiology of arterial stiffness in women than in men.

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“…1 Deterioration in endothelial function and arterial stiffness are early events in the development of cardiovascular damage. Although there is ample evidence that arteriosclerosis begins in childhood, [2][3][4] hard end points, such as stroke, ischemic heart disease and death, are rare or virtually lacking in the pediatric population.…”

Section: Introductionmentioning

confidence: 99%

Measurement of pulse wave velocity in children and young adults: a comparative study using three different devices

et al. 2011

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To estimate the value of pulse wave velocity (PWV) in pediatric cardiovascular disease, prospective studies are needed. Various instruments based on different measurement principles are proposed for use in children, hence the need to test the comparability of these devices in this younger population. The objective of this study was to compare PWV measured by oscillometry (Vicorder (VIC)) with the gold standard of applanation tonometry (PulsePen (PP), Sphygmocor (SC)). PWV was measured in 98 children and young adults (age: 16.7(6.3-26.6) years (median(range)) with the above three devices at the same visit under standardized conditions. Mean PWV measured by VIC was significantly lower than that measured by SC and PP. There was no difference following path length correction of the VIC measurement (using the distance between the jugular notch and the center of the femoral cuff), (PP: 6.12(1.00), SC: 5.94(0.91), VIC: 6.14(0.75) m s À1 ). Velocities measured by the three devices showed highly significant correlations. Bland-Altman analysis revealed excellent concordance between all three devices, however, there was a small but significant proportional error in the VIC measurements showing a trend toward lower PWV measured by VIC at higher PWV values. Our study provides data on the three most frequently used instruments in pediatrics. Following path length correction of the VIC, all three devices provided comparable results. Thus, our work allows extrapolating data between previously established normal PWV values for children and forthcoming studies using these instruments to assess children at long-term risk of cardiovascular disease. The small proportional error of VIC needs additional technical development to improve the accuracy of the measurements.

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Arterial Aging

Cited by 566 publications

References 104 publications

Attenuated Increases in Blood Pressure by Dynamic Resistance Exercise in Middle-Aged Men

Attenuated Increases in Blood Pressure by Dynamic Resistance Exercise in Middle-Aged Men

Predictive markers of abdominal aortic stiffness measured by echo-tracking in subjects with varying insulin sensitivity

Measurement of pulse wave velocity in children and young adults: a comparative study using three different devices

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