2014
DOI: 10.1038/jhh.2013.126
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Predictive markers of abdominal aortic stiffness measured by echo-tracking in subjects with varying insulin sensitivity

Abstract: Predictive markers of abdominal aortic stiffness measured by echo-tracking in subjects with varying insulin sensitivity. Link to publication Citation for published version (APA): Gottsäter, M., Länne, T., & Nilsson, P. M. (2014). Predictive markers of abdominal aortic stiffness measured by echo-tracking in subjects with varying insulin sensitivity. Journal of Human Hypertension, 28(7), 456-460. DOI: 10.1038456-460. DOI: 10. /jhh.2013 General rights Copyright and moral rights for the publications made accessi… Show more

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Cited by 6 publications
(4 citation statements)
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“…Some studies have demonstrated that diabetes should have a higher impact on arterial stiffness in women than in men [ 9 , 24 , 25 ] – results that could not be confirmed in this study. Longitudinal studies with more precise measurements of glucose metabolism and insulin sensitivity (clamp) are thus needed to shed more light on the pathophysiological mechanisms behind these associations.…”
Section: Discussioncontrasting
confidence: 91%
“…Some studies have demonstrated that diabetes should have a higher impact on arterial stiffness in women than in men [ 9 , 24 , 25 ] – results that could not be confirmed in this study. Longitudinal studies with more precise measurements of glucose metabolism and insulin sensitivity (clamp) are thus needed to shed more light on the pathophysiological mechanisms behind these associations.…”
Section: Discussioncontrasting
confidence: 91%
“…Together, our current finding that UCP-1 protein content was selectively increased in the aorta of iBATx mice that exhibited increased aortic stiffening is congruent with the aforementioned studies indicating that respiratory uncoupling may contribute to a dysfunctional vascular phenotype. Our finding that male mice appeared to be protected against Western diet-induced aortic stiffness is supported by previous reports indicating that men are less susceptible than women to metabolic dysfunction-induced aortic stiffening (11,22,50). Studies are needed to establish the mechanisms of this sexual dimorphism.…”
Section: Discussionsupporting
confidence: 89%
“…8 A follow-up study showed that arterial stiffness was improved by low-dose atorvastatin therapy in patients with hypertension and hypercholesterolemia. 22 Gottsäter et al 23 showed that there was negative association between HLD-C and aotic stiffness indicating the role of impaired lipid metabolism in the pathophysiology of arterial stiffness. Sacks showed that diabetic kidney disease is associated worldwide with higher levels of plasma TGs and lower levels of HDL-C among patients with good control of LDL-C, indicating the rationale for studying dyslipidemia treatment to prevent diabetic microvascular disease.…”
Section: Discussionmentioning
confidence: 99%