Predictive markers of abdominal aortic stiffness measured by echo-tracking in subjects with varying insulin sensitivity

Göttsater, Mikael; Länne, Toste; Nilsson, Peter M.

doi:10.1038/jhh.2013.126

Cited by 6 publications

(4 citation statements)

References 36 publications

(40 reference statements)

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“…Some studies have demonstrated that diabetes should have a higher impact on arterial stiffness in women than in men [ 9 , 24 , 25 ] – results that could not be confirmed in this study. Longitudinal studies with more precise measurements of glucose metabolism and insulin sensitivity (clamp) are thus needed to shed more light on the pathophysiological mechanisms behind these associations.…”

Section: Discussioncontrasting

confidence: 91%

Non-hemodynamic predictors of arterial stiffness after 17 years of follow-up

Göttsater

Östling

Persson

et al. 2015

Journal of Hypertension

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Background:Arterial stiffness plays a fundamental role in the development of hypertension and is a risk factor for both cardiovascular disease and mortality. The stiffening that occurs with increasing age has, in numerous cross-sectional studies, been shown to be associated with several cardiovascular risk factors. This observational study aims to characterize the predictive and cross-sectional markers focusing on the non-hemodynamic component of arterial stiffness.Method:In all, 2679 men and women from Malmö, Sweden, were examined at baseline during 1991–1994, and again at follow-up during 2007–2012 (mean age 72 years, 38% men). Follow-up examination included measurement of arterial stiffness by carotid–femoral pulse wave velocity (c-fPWV), after a mean period of 17 years. The associations between c-fPWV and risk markers were calculated with multiple linear regression.Results:The results indicated that for both sexes, waist circumference (β = 0.17, P < 0.001), fasting glucose (β = 0.13, P < 0.001), Homeostatic Model Assessment – Insulin Resistance (β = 0.10, P < 0.001), triglycerides (β = 0.10, P < 0.001), and high-density lipoprotein cholesterol (β = −0.08, P < 0.001) were all predictors of cfPWV adjusted for mean arterial pressure and heart rate, as well as for classical cardiovascular risk factors and drug treatment. There were no associations between baseline or follow-up low-density lipoprotein cholesterol, smoking, or eGFR and c-fPWV.Conclusion:The non-hemodynamic cluster of risk markers and predictors of arterial stiffness in a middle-aged population includes abdominal obesity, hyperglycemia, and dyslipidemia, but not smoking and low-density lipoprotein cholesterol. This pattern existed in both sexes.

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Section: Discussioncontrasting

confidence: 91%

Non-hemodynamic predictors of arterial stiffness after 17 years of follow-up

Göttsater

Östling

Persson

et al. 2015

Journal of Hypertension

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“…Together, our current finding that UCP-1 protein content was selectively increased in the aorta of iBATx mice that exhibited increased aortic stiffening is congruent with the aforementioned studies indicating that respiratory uncoupling may contribute to a dysfunctional vascular phenotype. Our finding that male mice appeared to be protected against Western diet-induced aortic stiffness is supported by previous reports indicating that men are less susceptible than women to metabolic dysfunction-induced aortic stiffening (11,22,50). Studies are needed to establish the mechanisms of this sexual dimorphism.…”

Section: Discussionsupporting

confidence: 89%

Removal of interscapular brown adipose tissue increases aortic stiffness despite normal systemic glucose metabolism in mice

Grunewald

Winn

Gastecki

et al. 2018

American Journal of Physiology-Regulatory, Integrative and Comp

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Brown adipose tissue (BAT) is considered protective against obesity and related cardiometabolic dysfunction. Indeed, activation of BAT improves glucose homeostasis and attenuates cardiovascular disease development. However, whether a reduction in BAT mass perturbs metabolic function and increases risk for cardiovascular disease remains largely unknown. To address this question, C57BL/6J male mice underwent a sham procedure or surgical bilateral excision of interscapular BAT (iBATx) and were fed a normal chow or a Western diet for 18 wk, creating four groups ( n = 10/group). Mice were housed at 25°C. As expected, the Western diet increased final body weight and adiposity; however, contrary to our hypothesis, iBATx did not potentiate adiposity independent of diet. Furthermore, iBATx did not affect indexes of glycemic control (HbA, fasting glucose and insulin, and glucose area under the curve during a glucose tolerance test) and produced minimal-to-no effects on lipid homeostasis. The absence of metabolic disturbances with iBATx was not attributed to regrowth of iBAT or a "browning" or proliferative compensatory response of other BAT depots. Notably, iBATx caused an increase in aortic stiffness in normal chow-fed mice only, which was associated with an increase in aortic uncoupling protein-1. Collectively, we demonstrated that, at 25°C (i.e., limited thermal stress conditions), a substantial reduction in BAT mass via iBATx does not disrupt systemic glucose metabolism, challenging the current dogma that preservation of BAT is obligatory for optimal metabolic function. However, iBATx caused aortic stiffening in lean mice, hence supporting the existence of an interplay between iBAT and aortic stiffness, independent of alterations in glucose homeostasis.

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“…8 A follow-up study showed that arterial stiffness was improved by low-dose atorvastatin therapy in patients with hypertension and hypercholesterolemia. 22 Gottsäter et al 23 showed that there was negative association between HLD-C and aotic stiffness indicating the role of impaired lipid metabolism in the pathophysiology of arterial stiffness. Sacks showed that diabetic kidney disease is associated worldwide with higher levels of plasma TGs and lower levels of HDL-C among patients with good control of LDL-C, indicating the rationale for studying dyslipidemia treatment to prevent diabetic microvascular disease.…”

Section: Discussionmentioning

confidence: 99%

Relationship between cardio-ankle vascular index and plasma lipids in hypertension subjects

et al. 2014

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An increasing of arterial stiffness is the path physiological characteristic of hypertension. Cardio-ankle vascular index (CAVI) is a new index of arterial stiffness. In the present study, we investigated the relationship between CAVI and plasma lipids in hypertension subjects. A total of 542 subjects (male/female 336/206) from the Department of Vascular Medicine were divided into two groups: healthy group (n=402) and hypertension group (n=140). CAVI was measured with VS-1000 apparatus. Our results showed that the levels of CAVI, body mass index (BMI), fast blood glucose (FBG), uric acid (UA) and triglycerides (TGs) were significantly higher in the hypertension group than in the control group (all P<0.01). High-density lipoprotein cholesterol (HDL-C) was significantly lower in the hypertension group than in the control group (P<0.001). CAVI was positively correlated with FBG, UA, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and TG in the entire study group. Negative correlation between CAVI and HDL-C was found in the entire group even after adjusting for age, gender and blood pressure. In addition, there was negative correlation between CAVI and HDL-C in the control group. However, there was negative relational tendency between CAVI and HDL-C in hypertension subjects without significant difference. Multiple linear regression analysis showed that age, BMI, FBG, TG and heart rate were independent associating factors of CAVI in all subjects. Age, FBG and Cr were independent associating factors of CAVI in the hypertension group. Our present study showed that CAVI was significantly higher in hypertension subjects, and metabolic accompaniments might involve the increasing of arterial stiffness in hypertension patients.

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Predictive markers of abdominal aortic stiffness measured by echo-tracking in subjects with varying insulin sensitivity

Cited by 6 publications

References 36 publications

Non-hemodynamic predictors of arterial stiffness after 17 years of follow-up

Non-hemodynamic predictors of arterial stiffness after 17 years of follow-up

Removal of interscapular brown adipose tissue increases aortic stiffness despite normal systemic glucose metabolism in mice

Relationship between cardio-ankle vascular index and plasma lipids in hypertension subjects

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