Cardiovascular Risk Factors Associated with Pulse Pressure in a Screened Cohort in Okinawa, Japan.

Inoue, Taku; Matsuoka, Masao; Nagahama, Kazufumi; Iseki, Chiho; Toriumi, Takashi; Iseki, Kunitoshi; Kinjo, Kozen; Takishita, Shuichi

doi:10.1291/hypres.26.153

Cited by 19 publications

(14 citation statements)

References 33 publications

(27 reference statements)

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“…Prehypertension is a useful category in which such parameters as C-reactive protein, plasma brain natriuretic peptide, or aldosterone (35)(36)(37) are measured to identify the subjects most likely to develop hypertension. Our previous reports demonstrated that pulse pressure and hyperuricemia were significantly associated with cardiovascular risk factors (29,38), their clustering (38) and the development of hypertension (39). Our results demonstrate that proteinuria, uric acid and pulse pressure could be other bio-measurements for identifying subjects who are at risk for this disease.…”

Section: Discussionsupporting

confidence: 51%

“…This means that the frequency of the development of hypertension in the Japanese might be lower than that of Western countries. The age-related increase in BP indicated a linear rise in SBP, but an early rise and a late fall in DBP, a divergent rather than parallel tracking pattern (28,29). In this cohort, all the subjects were normotensive, and had the same age-related BP pattern (Fig.…”

Section: Discussionmentioning

confidence: 76%

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Proteinuria as a Significant Determinant of Hypertension in a Normotensive Screened Cohort in Okinawa, Japan

et al. 2006

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To evaluate the influence of proteinuria on the development of hypertension in normotensive screened subjects. We studied 4,428 normotensive subjects without heart disease (2,888 men, 1,540 women, age 19-89 years) who were participants in a 1-day health evaluation in both 1997 and 2000. The 3-year frequency of developing hypertension was 6.0% in subjects without proteinuria, and 13.5% in subjects with proteinuria.

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Section: Discussionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 76%

Proteinuria as a Significant Determinant of Hypertension in a Normotensive Screened Cohort in Okinawa, Japan

et al. 2006

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“…Especially in women, there is positive correlation between serum uric acid level and leptin concentration (7). Some authors report that serum uric acid level is well correlated to prognosis of patients with type 2 diabetes and coronary heart disease (32)(33)(34). On the other hand, other authors report no correlation between serum uric acid concentration with mortality from cardiovascular disease, and another author reports that uric acid in the systemic blood flow works as an antioxidant to prevent atherosclerosis (35,36).…”

Section: Discussionmentioning

confidence: 99%

Effect of Fenofibrate on Uric Acid Metabolism in Japanese Hyperlipidemic Patients

Noguchi

Tatsuno

Suyama

et al. 2004

JAT

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Forty Type IIb or IV hyperlipidemic patients (serum triglyceride concentrations were higher than 150 mg/dl) were treated with fenofibrate (300 mg/day) for 12 weeks. Lipid profile and uric acid metabolism were evaluated before and after the treatment; the serum concentrations of total cholesterol and triglyceride respectively decreased from 224 ± ± ± ± ± 41.9 mg/dl to 199 ± ± ± ± ± 35.2 mg/dl and from 205 ± ± ± ± ± 71.7 mg/dl to 134 ± ± ± ± ± 67.5 mg/dl (p < 0.001). The uric acid concentrations in the serum also significantly decreased from 7.0 ± ± ± ± ± 1.58 mg/dl to 5.2 ± ± ± ± ± 1.57 mg/dl (p < 0.001). Fenofibrate treatment did not cause any change in the serum xanthine and hypoxanthine concentrations. Instead the urinary concentrations of uric acid decreased from 7.0 ± ± ± ± ± 1.58 mg/dl to 5.2 ± ± ± ± ± 1.57 mg/dl (p < 0.01), while the clearance ratio of uric acid and creatinin increased from 6.1 ± ± ± ± ± 2.56 to 9.9 ± ± ± ± ± 3.87 (p = 0.02) by the fenofibrate treatment. Fenofibrate decreases uric acid concentrations in the serum not as a result of inhibition of uric acid production but by increasing the urinary excretion of uric acid. J Atheroscler Thromb, 2004; 11: 335-340.

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“…The subjects were the participants of a 1-day health evaluation held by the Okinawa General Health Maintenance Association (OGHMA), which is one of the largest screening centers in Okinawa, Japan. 22 The OGHMA offers a 1-day health evaluation program throughout the year. This program provides thorough anthropometric measurements, a physical examination, laboratory tests and electrocardiography, both for individuals and health maintenance programs of companies and public organizations.…”

Section: Subjectsmentioning

confidence: 99%

Higher Heart Rate Predicts the Risk of Developing Hypertension in a Normotensive Screened Cohort

Inoue

Iseki

Iseki³

et al. 2007

Circ J

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ypertension is the most prevalent disorder that affects a vast majority of adults in Japan and is an important risk factor for myocardial infarction and cerebrovascular disease. 1 Among the metabolic syndrome components, hypertension is the strongest predictor for cardiovascular events 2 or carotid atherosclerosis. 3 Moreover, high blood pressure (BP) is a useful predictor for excess medical costs. 4 Therefore, the prevention of hypertension is an important public health issue. Patients with prehypertension are at an increased risk for progression to hypertension over a short period; those with a BP ranging 130-139/80-89 mmHg (systolic/diastolic) have twice the risk of developing hypertension as those with lower values. 5 Accordingly, identifying subjects with a high risk of developing hypertension will enable us to better target cost-effective interventions.The heart rate (HR) is easily obtained biologic information that requires no special instruments or techniques, in contrast to other recently developed biometric techniques. As HR fluctuates according to the method of measurement or condition, HR is an unreliable biometric marker to use for epidemiologic research. Furthermore, the significance of a higher HR tends to be underestimated in the clinical setting. Nonetheless, some studies report an association Circulation Journal Vol.71, November 2007 between HR and cardiovascular morbidity or mortality [6][7][8][9][10][11][12][13] and all causes of mortality. [7][8][9][10][11]14,15 A few studies report that HR is a predictor of developing hypertension. [16][17][18][19][20][21] We hypothesized that a high resting HR predicts the development of hypertension or BP progression, even after adjusting for risk factors such as metabolic syndrome or proteinuria. The aim of the present study was to evaluate whether a high HR predicts the development of hypertension and BP progression over a short period in normotensive, screened subjects. Methods SubjectsThis was a retrospective longitudinal study. The subjects were the participants of a 1-day health evaluation held by the Okinawa General Health Maintenance Association (OGHMA), which is one of the largest screening centers in Okinawa, Japan. 22 The OGHMA offers a 1-day health evaluation program throughout the year. This program provides thorough anthropometric measurements, a physical examination, laboratory tests and electrocardiography, both for individuals and health maintenance programs of companies and public organizations.Of 9,914 participants in the health screening program in 1997, 5,923 participated in this program in 2000. In the present analysis, 1,592 participants were excluded for the following reasons: prevalent hypertension (systolic BP ≥140 mmHg and/or diastolic BP ≥90 mmHg, or use of antihypertensive medications; n=1,408), no electrocardiogram (ECG) recording, or a record of ectopic beats or atrial fibrillation (n=780) or heart disease (history of heart disease or the use of medication for heart disease; n=46). ParticiCirc J 2007; 71: 1755 -1760 (Re...

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Cardiovascular Risk Factors Associated with Pulse Pressure in a Screened Cohort in Okinawa, Japan.

Cited by 19 publications

References 33 publications

Proteinuria as a Significant Determinant of Hypertension in a Normotensive Screened Cohort in Okinawa, Japan

Proteinuria as a Significant Determinant of Hypertension in a Normotensive Screened Cohort in Okinawa, Japan

Effect of Fenofibrate on Uric Acid Metabolism in Japanese Hyperlipidemic Patients

Higher Heart Rate Predicts the Risk of Developing Hypertension in a Normotensive Screened Cohort

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